Retinal Telangiectasis

A group of rare, idiopathic, congenital retinal vascular anomalies affecting the retinal capillaries. It is characterized by dilation and tortuosity of retinal vessels and formation of multiple aneurysms, with different degrees of leakage and exudates emanating from the blood vessels.

Also Known As:

Networked: 341 relevant articles (39 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Retinal Detachment (Retinal Detachments)
2.	Macular Edema
3.	Telangiectasis (Telangiectasia)
4.	Epiretinal Membrane (Epiretinal Membranes)
5.	Edema (Dropsy)

Experts

1.	Berrocal, Audina M: 10 articles (01/2022 - 03/2008)
2.	Shields, Carol L: 10 articles (10/2020 - 11/2004)
3.	Murray, Timothy G: 8 articles (09/2020 - 11/2005)
4.	Shields, Jerry A: 6 articles (01/2020 - 11/2004)
5.	Hubbard, G Baker: 4 articles (05/2022 - 03/2008)
6.	Kusaka, Shunji: 4 articles (01/2021 - 03/2014)
7.	Lu, Hai: 4 articles (01/2021 - 01/2016)
8.	Yannuzzi, Lawrence A: 4 articles (10/2018 - 06/2005)
9.	Kumar, Vinod: 4 articles (11/2017 - 06/2011)
10.	Li, Songfeng: 3 articles (01/2021 - 01/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Retinal Telangiectasis:

1.	Bevacizumab (Avastin)FDA Link 04/01/2010 - "Intravitreal bevacizumab appears to be a well-tolerated treatment for children with Coats disease. " 09/01/2018 - "Intravitreal bevacizumab may induce rapidly progressive "ERM" in patients with juvenile Coats' disease." 01/01/2014 - "The purpose of this article was to evaluate the effect of intravitreal bevacizumab as the initial treatment for Coats' disease in children and adults. " 01/01/2014 - "The effect of intravitreal bevacizumab injection as the initial treatment for Coats' disease." 03/01/2013 - "Treatment of Coats' disease with intravitreal bevacizumab."
2.	Ranibizumab (Lucentis)FDA Link 01/01/2009 - "Intravitreal ranibizumab showed promising results for subretinal neovascularization due to idiopathic juxtafoveal retinal telangiectasis. " 01/01/2020 - "Optical Coherence Tomography Angiography Findings After Intravitreal Ranibizumab in Patients With Coats Disease." 11/01/2017 - "INTRAVITREAL RANIBIZUMAB AS AN ADJUNCTIVE TREATMENT FOR COATS DISEASE (6-YEAR FOLLOW-UP)." 06/01/2016 - "Successful use of intravitreal ranibizumab injection and combined treatment in the management of Coats' disease." 11/01/2014 - "ranibizumab in the management of advanced Coats disease Stages 3B and 4: long-term outcomes."
3.	Retinaldehyde (Retinal)IBA 01/01/2021 - "Furthermore, UWF imaging helped us to highlight vascular changes typical of Coats Disease at the far retinal periphery. " 11/08/2023 - "Coats' disease is an idiopathic retinal vascular disorder, known to usually occur unilaterally; however, recent studies have highlighted vascular abnormalities in the fellow unaffected eyes. " 01/01/2023 - "Coats' disease, described by George Coats in the early 1900s, is an idiopathic unilateral retinal vascular abnormality with exudation occurring in young males. " 01/01/2023 - "To describe and quantify the abnormalities of the retinal capillary plexuses using optical coherence tomography angiography in Coats disease. " 01/01/2023 - "ABNORMALITIES IN THE RETINAL CAPILLARY PLEXUSES IN COATS DISEASE IN ADULTHOOD ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY."
4.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/01/2023 - "Conclusions: The results of this study indicate that anti-VEGF drugs provide an effective and relatively safe treatment strategy for Coats' disease. " 01/01/2023 - "Methods: PubMed, Embase, The Cochrane Library, Clinical Trials, CNKI, and WanFang databases were systematically searched for clinical efficacy and safety studies on anti-VEGF treatment for Coats' disease through June 2021. " 01/01/2023 - "This study was designed to evaluate the efficacy and safety of anti-VEGF treatment for Coats' disease. " 07/08/2023 - "This retrospective, observational study included a total of 62 eyes in 62 pediatric patients with juvenile Coats disease treated with intravitreal anti-VEGF agents followed for a mean of 67.08 months (ranged from 60 to 93 months). " 01/01/2023 - "Purpose: The efficacy and safety of anti-vascular endothelial growth factor (anti-VEGF) treatment for Coats' disease remains controversial. "
5.	ArgonIBA 01/01/2001 - "To study the different clinical presentation of the idiopathic juxtafoveolar retinal telangiectasis and its treatment with argon laser. " 05/01/2020 - "We made a diagnosis of stage 2A Coats disease and performed argon laser photocoagulation (PC). " 06/01/1989 - "Treatment of Coats' disease with the binocular indirect argon laser photocoagulator." 04/01/1979 - "[Treatment of Coats' disease with argon laser photocoagulation]." 04/01/1991 - "A 28-year-old man with unilateral Coats' disease and cystoid macular edema secondary to juxtafoveolar telangiectasis underwent successful juxtafoveolar argon green laser photocoagulation therapy with resolution of the edema and improvement in metamorphopsia and visual acuity. "
6.	KH902 fusion proteinIBA 12/26/2020 - "This retrospective case series study included patients diagnosed with Coats disease and treated with intravitreal conbercept injection and 532-nm laser photocoagulation at the Ophthalmology Department of Shenzhen People's Hospital between January 2016 and January 2017. " 12/26/2020 - "To evaluate the long-term outcomes of intravitreal conbercept injection with laser photocoagulation as a treatment for Coats disease in adults. " 12/26/2020 - "Three-year follow-up of Coats disease treated with conbercept and 532-nm laser photocoagulation." 12/26/2020 - "Intravitreal injection of conbercept combined with 532-nm laser photocoagulation may be a feasible treatment for Coats disease in adult patients." 07/01/2018 - "Moreover, the intravitreal injection of ranibizumab or conbercept had no significant adverse effects and appeared to offer visual improvement in Coats' disease."
7.	Dexamethasone (Maxidex)FDA LinkGeneric 05/01/2020 - "Dexamethasone intravitreal implantation was effective in treating refractory Coats disease." 07/01/2023 - "In conclusion, dexamethasone intravitreal implant may be a useful adjuvant treatment to consider in some pediatric cases with Coats' disease." 07/01/2023 - "Dexamethasone intravitreal implant as an adjuvant treatment for pediatric patients with Coats' disease." 05/01/2020 - "Refractory adult Coats disease treated with dexamethasone intravitreal implant: A case report." 01/01/2020 - "A consecutive case series of adult Coats' disease managed with or without intravitreal dexamethasone implant (Ozurdex®, Allergan Inc., Irvine, California, USA) injection was retrospectively evaluated. "
8.	Fluorescein (Funduscein)FDA LinkGeneric 10/01/2021 - "Clinical investigation of both eyes of each patient with diagnosed Coats' disease using ultra-widefield (UWF) fundus imaging, including UWF fluorescein angiography (UWFFA), spectral domain optical coherence tomography (OCT) and optical coherence tomography angiography (OCT-A). " 01/01/2019 - "RetCam fluorescein angiography confirmed the diagnosis of bilateral Coats disease." 01/01/2019 - "Longitudinal Examination of Fellow-Eye Vascular Anomalies in Coats' Disease With Widefield Fluorescein Angiography: A Multicenter Study." 01/01/2019 - "To compare optical coherence tomography (OCT) with fundus photographs, fluorescein angiography (FA), and histopathologic findings in Coats disease. " 01/01/2019 - "Comparison of Optical Coherence Tomography With Fundus Photographs, Fluorescein Angiography, and Histopathologic Analysis in Assessing Coats Disease."
9.	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 01/01/2022 - "Adjunctive Intravitreal Triamcinolone Acetonide for Exudative Retinal Detachment in Coats Disease." 01/01/2009 - "To investigate the efficacy of intravitreal injection of triamcinolone acetonide (TA) for treatment of cystoid foveal edema (CFE) associated with Coats' disease. " 01/01/2022 - "This work aims to assess the value of intravitreal triamcinolone acetonide (IVTA) as an adjunctive therapy in advanced Coats disease with exudative retinal detachment (ERD). " 01/01/2009 - "Intravitreal injection of triamcinolone acetonide to treat cystoid foveal edema associated with coats' disease." 01/01/2023 - "Retracted: Clinical Study of Intravitreal Injection of Anti-VEGF Drugs Combined with Triamcinolone Acetonide in the Treatment of Coats Disease."
10.	afliberceptIBA 07/01/2022 - "To report long-term results of treatment with intravitreal injections of aflibercept in a newly diagnosed case of Coats disease. " 07/01/2022 - "TWO-YEAR RESULTS OF INTRAVITREAL INJECTIONS OF AFLIBERCEPT IN COATS DISEASE: A CASE REPORT." 09/25/2020 - "To our knowledge, this is the first case treated with laser and intravitreal aflibercept with a long three-year follow-up suggesting the significant role of aflibercept in vascular permeability and supporting its use as a valuable therapeutic option for Coats' disease." 09/25/2020 - "We report long-term results of treatment with intravitreal injection of aflibercept in a newly diagnosed case of adult-onset Coats' disease. " 09/25/2020 - "We therefore believe that aflibercept is an excellent adjunctive therapy in cases of adult-onset Coats' disease with macular edema. "

Therapies and Procedures

1.	Lasers (Laser) 07/01/2016 - "To describe the outcomes of children with Coats disease treated with 577-nm yellow laser indirect ophthalmoscopy. " 11/01/2005 - "Laser treatment of Coats' disease." 01/01/2015 - "We conclude that 25GPPV combined with ERM peeling, laser photocoagulation, and cryoretinopexy can be effective for adult-onset Coats' disease associated with an ERM." 05/01/2023 - "Results: A 27-year-old patient with Coats disease who was treated 5 years earlier with laser photocoagulation presented with an FTMH. " 07/18/2022 - "In mild and moderate cases of Coats disease, laser photocoagulation monotherapy may help preserve vision. "
2.	Therapeutics 01/01/2018 - "In this retrospective series of patients with Stage 3B Coats disease, ablative therapy with a combination of PPV, XD, or SB was effective in preventing progression to NVG or phthisis in the majority of patients, thus preserving the globe. " 01/01/2020 - "Multiple Therapy Approach for Stage 3 Coats Disease: Long-Term Follow-Up." 01/01/2016 - "To report on the outcome of conventional therapy in patients with Coats' disease. " 09/01/2013 - "Coats' disease and FEVR are both progressive diseases requiring lifelong follow-up and therapy. " 03/01/2007 - "In this article we share our experience of treating various severities of Coats' disease and focus on optimal therapy for advanced disease. "
3.	Light Coagulation 11/01/2009 - "To study the characteristic and rule of macular disease involved by Coats disease and macular changes after photocoagulation. " 07/01/2015 - "Treatment of stage 3 Coats' disease by endolaser photocoagulation via a two-port pars plana nonvitrectomy approach." 11/01/2002 - "Selective photocoagulation in Coats disease: ten-year follow-up." 11/01/2002 - "Selective photocoagulation in Coats' disease: ten-year follow-up." 04/01/1976 - "71 eyes with Coats' disease were treated with photocoagulation. "
4.	Vitrectomy 01/01/2016 - "Instead of performing vitrectomy and internal drainage with a drainage hole in the retina, less-invasive procedures that do not require retinotomy appear to be beneficial in cases of advanced Coats' disease. " 01/01/2016 - "We report a case of advanced Coats' disease in which a rapid pathological examination of subretinal fluid was effective for the diagnosis, and external subretinal drainage combined with vitrectomy was effective in preserving the eye. " 01/01/2016 - "Subretinal Fluid Drainage and Vitrectomy Are Helpful in Diagnosing and Treating Eyes with Advanced Coats' Disease." 05/01/2023 - "Conclusions: Although the healing process after vitrectomy with ILM peeling and the inverted flap technique in an FTMH coexisting with Coats disease is prolonged compared with an idiopathic FTMH, it is still possible to obtain satisfactory anatomic and functional results." 01/01/2021 - "External Drainage Alone Versus External Drainage With Vitrectomy in Advanced Coats Disease."
5.	Cryotherapy (Therapy, Cold) 11/01/2020 - "SRF drainage and cryotherapy in eyes with advanced Coats disease favorably alter the natural history of the disease and prevent end-stage complications. " 10/11/2018 - "Coats disease is generally treated using laser photocoagulation and cryotherapy to ablate the abnormal retinal blood vessels. " 06/01/2014 - "The presented modified technique allows for sufficient cryotherapy of vascular malformations, even in the presence of massive exudation, in a subset of patients with advanced Coats' disease, and thus may reduce surgery-related complications and improve the rehabilitation process of these young patients." 05/01/2012 - "Fundus examination revealed stage 3A Coats disease with macular exudation and a serous retinal detachment in the inferior quadrants requiring the placement of an encircling band, external drainage, and cryotherapy of the vascular lesions. " 11/01/2002 - "This is the first report of anatomical benefits from treatment with a yellow-dye laser (i.e., selective photocoagulation without cryotherapy or drainage) despite the presence of a severe form of Coats disease. "