Invasive Candidiasis

An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.

Also Known As:

Networked: 1097 relevant articles (132 outcomes, 192 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Aspergillosis
2.	Candidemia
3.	Candidiasis (Moniliasis)
4.	Critical Illness (Critically Ill)
5.	Infections

Experts

1.	Walsh, Thomas J: 28 articles (01/2019 - 12/2002)
2.	Benjamin, Daniel K: 23 articles (01/2020 - 08/2006)
3.	Ostrosky-Zeichner, Luis: 18 articles (12/2021 - 12/2003)
4.	Roilides, Emmanuel: 14 articles (01/2022 - 09/2002)
5.	Perfect, John R: 13 articles (08/2022 - 05/2003)
6.	Quindós, Guillermo: 13 articles (01/2022 - 02/2004)
7.	Pappas, Peter G: 12 articles (08/2022 - 06/2007)
8.	Wiederhold, Nathan P: 12 articles (08/2022 - 01/2008)
9.	Clancy, Cornelius J: 12 articles (11/2021 - 05/2006)
10.	Pontón, José: 12 articles (03/2010 - 03/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Invasive Candidiasis:

1.	EchinocandinsIBA 08/01/2021 - "Echinocandins are highly effective against Candida species and recommended for treatment of invasive candidiasis. " 10/01/2007 - "The echinocandins have potent fungicidal activity against most Candida species, but there are few data comparing the safety and efficacy of echinocandins in the treatment of invasive candidiasis. " 10/01/2018 - "Significantly Improved Pharmacokinetics Enhances In Vivo Efficacy of APX001 against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis." 10/03/2023 - "Echinocandins are recommended as first-line treatment in guidelines for invasive candidiasis. " 11/16/2023 - "Echinocandins are the first-line treatment of invasive candidiasis caused by C. "
2.	Caspofungin (Cancidas)FDA Link 07/01/2011 - "These data suggest that caspofungin dose escalation for invasive candidiasis may not be consistently effective against resistant C. " 08/01/2007 - "Caspofungin has demonstrated efficacy in invasive candidiasis. " 08/01/2010 - "A multicentre study to evaluate the impact of timing of caspofungin administration on outcomes of invasive candidiasis in non-immunocompromised adult patients." 05/01/2010 - "We identified 212 patients with invasive candidiasis due to non-albicans Candida species (>or=5 cases per species) in 5 clinical trials of caspofungin monotherapy from the pharmaceutical sponsor's (Merck and Co., Inc.) database: 71 cases were caused by C. " 06/15/2009 - "A Multicenter, double-blind trial of a high-dose caspofungin treatment regimen versus a standard caspofungin treatment regimen for adult patients with invasive candidiasis."
3.	Fluconazole (Zonal)FDA LinkGeneric 12/01/2018 - "Extremely premature infants are at high risk of developing invasive candidiasis; fluconazole prophylaxis is safe and effective for reducing invasive candidiasis in this population but further study is needed. " 12/01/2014 - "Fluconazole is recommended as first-line treatment in invasive candidiasis in children and infants. " 01/01/2016 - "Fluconazole is an effective agent for prophylaxis of invasive candidiasis in premature infants. " 03/01/2011 - "Fluconazole is used extensively in human medicine to treat mucosal and invasive candidiasis and has been used in birds; however, there have been few pharmacokinetic studies in avian species to guide safe and effective treatment. " 11/01/1996 - "Because of its pharmacokinetic properties, fluconazole can be specially useful in the treatment of invasive candidiasis. "
4.	AnidulafunginFDA Link 06/01/2004 - "The clearance of anidulafungin was influenced by weight and gender, and subjects in the invasive candidiasis study had a typical clearance that was approximately 30% higher than subjects from other studies. " 01/01/2017 - "These data demonstrate that anidulafungin is effective for treatment of candidaemia and invasive candidiasis in a broad patient population." 01/01/2019 - "A Prospective, Open-label Study to Assess the Safety, Tolerability and Efficacy of Anidulafungin in the Treatment of Invasive Candidiasis in Children 2 to <18 Years of Age." 01/01/2017 - "Efficacy of anidulafungin in 539 patients with invasive candidiasis: a patient-level pooled analysis of six clinical trials." 01/01/2003 - "In January 2003, Versicor announced that positive results from a phase II trial for anidulafungin IV treatment involving 120 patients in the US with invasive candidiasis/candidaemia, have led to another double-blind, randomised phase III trial being conducted in the US, Canada and Europe for this indication. "
5.	Micafungin (FK463)FDA Link 03/31/2009 - "Micafungin is safe and effective in the treatment of children and adults with invasive candidiasis. " 02/01/2014 - "Efficacy of micafungin in invasive candidiasis caused by common Candida species with special emphasis on non-albicans Candida species." 10/05/2021 - "During the XXX (INTENSE) study into the preemptive use of micafungin to prevent invasive candidiasis (IC) after abdominal surgery, the serum burden of BDG was determined to aid diagnosis of IC. " 01/01/2021 - "High-Dose Micafungin in Neonates and Young Infants with Invasive Candidiasis: Results of a Phase 2 Study." 03/31/2009 - "Althought the European Medicines Agency approved in 2008 the use of Micafungin for the treatment of invasive candidiasis in children, the available clinical experience is limited and currently more clinical studies are warranted to define its efficacy and safety in neonates."
6.	Amphotericin B (Amphotericin)FDA LinkGeneric 04/01/1989 - "We have reviewed 38 patients with invasive candidiasis and examined its predisposing factors, usefulness and limitation of cultural study in its diagnosis, and effective usage of amphotericin B in its treatment. " 12/01/2020 - "Pharmacokinetic and pharmacodynamic profiling of generic amphotericin B colloidal dispersion in a rat model of invasive candidiasis." 10/15/2012 - "The objective of this work was to assess the antifungal activity of a tropically stable formulation of amphotericin B (AmB) (iCo-010) over short period of treatment in a rat model of invasive candidiasis. " 07/01/2003 - "Antibody to HSP90 is closely associated with recovery in patients with invasive candidiasis who are receiving amphotericin B (AMB). " 10/01/1994 - "Analysis of the spectrum of colonizing Candida spp. showed that multicolonized subjects were colonized with increased frequently by Candida albicans compared to monocolonized subjects, and that the association between multicolonization, invasive candidiasis and amphotericin B usage was statistically significant in patients colonized by Candida albicans but not in patients colonized by other Candida species. "
7.	Antifungal AgentsIBA 11/28/2022 - "This study identified barriers to enrolment in clinical trials assessing novel antifungal agents in invasive candidiasis. " 05/01/2015 - "We reviewed the medical literature and extracted information on clinical and observational studies evaluating the use of antifungal agents in neonates with invasive candidiasis. " 01/01/2014 - "The aim of the study was to determine the prevalence of yeast-like fungi in invasive candidiasis and to estimate its susceptibility to chosen antifungal agents. " 02/01/2011 - "The aim of our study was to analyze the spectrum and characteristic of invasive candidiasis in selected haematological departments in the Czech and Slovak Republics, and to compare minimum inhibitory concentrations (MIC) of some antifungal agents for isolates obtained. " 11/01/2017 - "Indeed, the authors see this technology as a powerful tool to help scientists identify new antifungal agents that can be added to the clinician's arsenal in their fight against invasive candidiasis."
8.	Voriconazole (Vfend)FDA LinkGeneric 10/01/2020 - "Voriconazole was associated with a significant reduction in invasive candidiasis (RR, 0.15; 95% CI, 0.09-0.26) compared with placebo. " 12/01/2010 - "Economic data to guide the use of voriconazole as prophylaxis or empirical therapy as well as targeted therapy against invasive candidiasis remain limited." 11/01/2003 - "Voriconazole salvage treatment of invasive candidiasis." 12/01/2019 - "The PK simulations in this study suggest that transplant recipients on voriconazole prophylaxis against invasive candidiasis or aspergillosis are likely to achieve the target concentrations associated with the desired treatment outcomes if the maintenance dose is 200 mg twice daily. " 12/01/2019 - "To evaluate the adequacy of different dosing regimens of voriconazole for the prophylaxis of invasive candidiasis and aspergillosis in adult allogeneic stem cell transplant recipients by means of population pharmacokinetic (PK) modelling and simulation. "
9.	AzolesIBA 10/15/2019 - "This study provides evidence that the combination of azoles and MTX is effective for patients with invasive candidiasis, which on the other hand, will reduce the side effects of the drugs." 10/15/2019 - "This study aims to evaluate the effective of azoles and MTX for patients with invasive candidiasis. " 01/01/2001 - "Further studies are needed to delineate the relationship between azole MICs and treatment outcomes of invasive candidiasis due to non-C. " 01/01/2022 - "The changing landscape of azole-resistant invasive candidiasis." 07/06/2021 - "This is the first report of an invasive candidiasis outbreak in Mexico due to azole-resistant C. "
10.	AntibodiesIBA 01/01/2019 - "Corrigendum to "Performance of Candida albicans germ tube antibodies (CAGTA) and its association with (1 → 3)-β-D-glucan (BDG) for diagnosis of invasive candidiasis (IC)" [Diagn Microbiol Infect Dis 2019;93(1):39-43]." 01/01/2019 - "Performance of Candida albicans germ tube antibodies (CAGTA) and its association with (1 → 3)-β-D-glucan (BDG) for diagnosis of invasive candidiasis (IC)." 01/01/2011 - "Prediction of the clinical outcome in invasive candidiasis patients based on molecular fingerprints of five anti-Candida antibodies in serum." 09/01/2005 - "Syscan3, a kit for detection of anti-Candida antibodies for diagnosis of invasive candidiasis." 10/01/2002 - "Our observations may also help explain why subjects with elevated anti-Candida antibody titers, inclusive of anti-MP and anti-GG antibodies, remain nonetheless susceptible to invasive candidiasis."

Therapies and Procedures

1.	Therapeutics 09/01/2009 - "Early diagnosis and prompt initiation of antifungal therapy are crucial for the effective treatment of invasive candidiasis. " 11/01/2019 - "Efficacy of Delayed Therapy with Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis." 01/01/2020 - "No randomized studies on antifungal prophylaxis in AP are available; some reports though recommend using such therapy among patients at high risk of invasive candidiasis." 12/01/2016 - "Systemic antifungal therapy for proven or suspected invasive candidiasis: the AmarCAND 2 study." 11/01/2015 - "From the 835 non-neutropenic adults recruited in the multicenter prospective observational AmarCAND2 study, we selected the patients receiving systemic antifungal therapy for a documented or suspected invasive candidiasis in the ICU and who were still alive 5 days after SAT initiation. "
2.	Critical Care (Surgical Intensive Care) 09/01/2014 - "Although there has been an improved management of Invasive Candidiasis in the last decade, still controversial issues remain, especially in different therapeutic critical care scenarios. " 07/01/2014 - "Although there has been an improved management of invasive candidiasis in the last decade, still controversial issues remain, especially in different therapeutic critical care scenarios. " 07/01/2017 - "One hundred and thirty-seven surgical intensive care unit (ICU) patients with intra-abdominal invasive Candidiasis were included in the study. " 12/01/2013 - "Invasive candidiasis in pediatric intensive care in Greece: a nationwide study." 04/01/2007 - "The study presented here was performed in order to create a rule that identifies subjects at high risk for invasive candidiasis in the intensive care setting. "
3.	Salvage Therapy 11/01/2003 - "Voriconazole salvage treatment of invasive candidiasis." 03/01/2009 - "Caspofungin is used for the treatment of acute invasive candidiasis and as salvage treatment for invasive aspergillosis. " 05/01/2003 - "Caspofungin is a promising agent as first-line therapy for invasive candidiasis, and as salvage therapy for invasive aspergillosis. " 04/01/2007 - "Caspofungin has demonstrated efficacy in experimental models of invasive candidiasis and aspergillosis, which reflect its activity in the treatment of oropharyngeal, esophageal and disseminated candidiasis, as well as salvage therapy for patients with invasive aspergillosis." 11/29/2020 - "Clinical trials have found it to be noninferior to voriconazole for invasive aspergillosis, an alternative therapy for salvage treatment of mucormycosis, and suitable for stepdown therapy with invasive candidiasis. "
4.	Liver Transplantation 06/27/2003 - "This study determines whether the spectrum, risk factors, and outcome of invasive candidiasis in liver transplant recipients have changed. " 06/27/2003 - "Changes in the spectrum and risk factors for invasive candidiasis in liver transplant recipients: prospective, multicenter, case-controlled study." 03/01/2016 - "Invasive candidiasis in liver transplant patients: Incidence and risk factors in a pediatric cohort." 03/01/2015 - "Invasive candidiasis (IC) causes high morbidity and mortality rates after liver transplantation, in part due to delayed diagnosis. " 05/13/2014 - "Invasive Candidiasis due to Candida Norvegensis in a Liver Transplant Patient: Case Report and Literature Review."
5.	Chemoprevention 08/01/2023 - "In addition, 28% and 22% of practicing physicians chose a combination of antifungals for the chemoprophylaxis of invasive candidiasis and invasive aspergillosis, respectively. " 04/01/1984 - "In placebo-controlled studies, high doses of antifungal agents decreased the positive results from surveillance cultures, and there is some suggestion that such chemoprophylaxis may reduce the incidence of invasive candidiasis in neutropenic cancer patients. "