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EP3 Subtype Prostaglandin E Receptors

A subtype of prostaglandin E receptors that specifically couples to GTP-BINDING PROTEIN ALPHA SUBUNIT, GI and subsequently inhibits ADENYLYL CYCLASES.
Also Known As:
Receptors, Prostaglandin E, EP3 Subtype; PGE Receptor, EP3 Subtype; Prostaglandin E Receptor 3; Prostaglandin E2 Receptor, EP3 Subtype; Prostanoid Receptor EP3; EP3, Prostanoid Receptor; Receptor EP3, Prostanoid
Networked: 16 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Ueta, Mayumi: 7 articles (01/2021 - 12/2010)
2. Kinoshita, Shigeru: 5 articles (01/2020 - 12/2010)
3. Sotozono, Chie: 5 articles (01/2020 - 12/2010)
4. Tashiro, Kei: 2 articles (01/2015 - 12/2010)
5. Inatomi, Tsutomu: 2 articles (01/2011 - 12/2010)
6. Yokoi, Norihiko: 2 articles (01/2011 - 12/2010)
7. Fujino, Hiromichi: 1 article (01/2022)
8. Fukushima, Keijo: 1 article (01/2022)
9. Mieno, Hiroki: 1 article (01/2020)
10. Nakayama, Tomomichi: 1 article (01/2020)

Related Diseases

1. Stevens-Johnson Syndrome (Lyell's Syndrome)
2. Inflammation (Inflammations)
12/01/2016 - "Further analysis of the altered genes in cellular immunity and inflammation gene clusters identified prostaglandin E receptor 3 (EP3) as a key regulator of gene expression in response to acRoots. "
11/01/2018 - "Single nucleotide polymorphism association analysis showed that the Toll-like receptor 3 (TLR3), prostaglandin-E receptor 3 (PTGER3), and IKZF1 gene were significantly associated with CM-SJS/TEN with SOC and that they could regulate mucocutaneous inflammation including that of the ocular surface. "
01/01/2021 - "Our investigation of the pathogenesis of SJS/TEN with SOC led us to suspect that abnormal innate mucosal immunity contributes to the ocular surface inflammation seen in SJS/TEN with SOC. We confirmed that cold medicines such as NSAIDs and multi-ingredient cold medications are the main causative drugs for SJS/TEN with SOC. Single nucleotide polymorphism (SNP) association analysis of cold medicine-related SJS/TEN with SOC showed that the Toll-like receptor 3 (TLR3)-, the prostaglandin-E receptor 3 (PTGER3)-, and the IKZF1 gene were significantly associated with SNPs and that these genes could regulate mucocutaneous inflammation including that of the ocular surface. "
11/01/2012 - "We previously reported that prostaglandin (PG) E2 acts as a ligand for prostaglandin E receptor 3 (EP3) in conjunctival epithelial cells, that it downregulates the progression of experimental murine allergic conjunctivitis, and that in human conjunctival epithelial cells it modulates the expression of polyI:C-induced proinflammatory genes via prostaglandin E receptor 2 (EP2) and EP3, suggesting that PGE2 might have important roles in ocular surface inflammation such as allergic conjunctivitis. "
3. Colorectal Neoplasms (Colorectal Cancer)
4. Sarcoma (Soft Tissue Sarcoma)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Toll-Like Receptor 3
2. Dinoprostone (PGE2)
3. Proteins (Proteins, Gene)
4. Prostaglandins
5. Claudin-5
6. EP2 Subtype Prostaglandin E Receptors
7. Multi-Ingredient Cold, Flu, and Allergy Medications
8. KATP Channels
9. Non-Receptor Type 6 Protein Tyrosine Phosphatase
10. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)