Receptor Activity-Modifying Protein 3

A receptor activity-modifying protein that heterodimerizes with CALCITONIN RECEPTOR-LIKE PROTEIN to form the ADRENOMEDULLIN RECEPTOR. In addition, an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.

Also Known As:

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chang, Jin Rui: 1 article (03/2016)
2.	Du, Jie: 1 article (03/2016)
3.	Guan, You Fei: 1 article (03/2016)
4.	Guo, Jun: 1 article (03/2016)
5.	Hou, Yue Long: 1 article (03/2016)
6.	Liu, Xiu Ying: 1 article (03/2016)
7.	Lu, Wei Wei: 1 article (03/2016)
8.	Qi, Yong Fen: 1 article (03/2016)
9.	Tang, Chao Shu: 1 article (03/2016)
10.	Wang, Xiu Jie: 1 article (03/2016)

Related Diseases

1.	Vascular Calcification 03/01/2016 - "The aortas of rats with CKD showed reduced IMD content but an increase of its receptor, calcitonin receptor-like receptor, and its receptor modifier, receptor activity-modifying protein 3. IMD1-53 treatment reduced vascular calcification. "
2.	Neoplasms (Cancer) 01/01/2016 - "Adrenomedullin (AM) is a multifunctional peptide that is highly expressed in several tumors and plays an important role in angiogenesis and tumor growth after binding to its receptors, calcitonin receptor-like receptor/receptor activity-modifying protein 2 (CLR/RAMP2) and calcitonin receptor-like receptor/receptor activity-modifying protein 3 (CLR/RAMP3). "
3.	Heart Failure 01/01/2012 - "Loss of receptor activity-modifying protein 3 exacerbates cardiac hypertrophy and transition to heart failure in a sex-dependent manner."
4.	Cardiomegaly (Heart Hypertrophy) 01/01/2012 - "Loss of receptor activity-modifying protein 3 exacerbates cardiac hypertrophy and transition to heart failure in a sex-dependent manner."
5.	Diabetic Nephropathies (Diabetic Nephropathy) 02/01/2004 - "Since adrenomedullin (AM) elicits vasodilatation by binding to specific AM receptors consisted of calcitonin-receptor-like receptor (CRLR)/receptor-activity-modifying protein 2 (RAMP2) or CRLR/receptor-activity-modifying protein 3 (RAMP3) on endothelial cells and stimulating nitric oxide production, AM possibly involves in glomerular capillary dilatation in early phase of diabetic nephropathy. "

Related Drugs and Biologics

1.	Calcitonin Receptor-Like Protein
2.	Receptor Activity-Modifying Protein 2
3.	Adrenomedullin
4.	Calcitonin Receptors (Calcitonin Receptor)
5.	Catenins
6.	Extracellular Matrix Proteins
7.	Peptides (Polypeptides)
8.	Nitric Oxide (Nitrogen Monoxide)