Receptor Activity-Modifying Protein 2

A receptor activity-modifying protein that heterodimerizes with CALCITONIN RECEPTOR-LIKE PROTEIN to form the ADRENOMEDULLIN RECEPTOR. In addition, an isoform of the ISLET AMYLOID POLYPEPTIDE RECEPTOR is formed from this protein dimerizing with the CALCITONIN RECEPTOR.

Also Known As:

Networked: 19 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ichikawa-Shindo, Yuka: 2 articles (01/2021 - 07/2015)
2.	Kamiyoshi, Akiko: 2 articles (01/2021 - 07/2015)
3.	Kawate, Hisaka: 2 articles (01/2021 - 07/2015)
4.	Sakurai, Takayuki: 2 articles (01/2021 - 07/2015)
5.	Shindo, Takayuki: 2 articles (01/2021 - 07/2015)
6.	Caron, Kathleen M: 2 articles (01/2020 - 01/2016)
7.	Delfino, Christine: 2 articles (01/2016 - 11/2009)
8.	Martin, Pierre-Marie: 2 articles (01/2016 - 11/2009)
9.	Ouafik, L'Houcine: 2 articles (01/2016 - 11/2009)
10.	Fan, Xin-Rong: 2 articles (08/2006 - 08/2005)

Related Diseases

1.	Lung Injury 01/01/2020 - "Adrenomedullin (AM) signals through calcitonin receptor-like receptor and receptor activity-modifying protein 2 and modulates lung injury initiation. " 12/15/2021 - "To study the role of adrenomedullin (ADM) in hyperoxia-induced lung injury by examining the effect of ADM on the expression of calcitonin receptor-like receptor (CRLR), receptor activity-modifying protein 2 (RAMP2), extracellular signal-regulated kinase (ERK), and protein kinase B (PKB) in human pulmonary microvascular endothelial cells (HPMECs) under different experimental conditions. "
2.	Pheochromocytoma 08/01/2005 - "To investigate the expression of human adrenomedullin (ADM) and its receptor-receptor activity modifying protein 2/calcitonin receptor-like receptor (RAMP2/CRLR) mRNA in the tissues of normal adrenal medulla and pheochromocytoma. " 08/01/2006 - "This study investigates the expression of human adrenomedullin (ADM) and its receptor-receptor activity modifying protein 2/calcitonin receptor-like receptor (RAMP2/CRLR) mRNA in pheochromocytoma by reverse transcriptase polymerase chain reaction (RT-PCR) and its effect on the proliferation of pheochromocytoma cells by MTT. "
3.	Hyperoxia 12/15/2021 - "To study the role of adrenomedullin (ADM) in hyperoxia-induced lung injury by examining the effect of ADM on the expression of calcitonin receptor-like receptor (CRLR), receptor activity-modifying protein 2 (RAMP2), extracellular signal-regulated kinase (ERK), and protein kinase B (PKB) in human pulmonary microvascular endothelial cells (HPMECs) under different experimental conditions. "
4.	Lung Neoplasms (Lung Cancer) 08/01/2007 - "Pathologic and functional analyses were done to study the role of one candidate gene, receptor activity-modifying protein 2 (RAMP2), in suppressing lung cancer cell growth. "
5.	Neoplasms (Cancer) 11/29/2022 - "AM impacts angiogenesis and tumor growth and binds to calcitonin receptor-like receptor/receptor activity-modifying protein 2 or 3 (CLR/RAMP2; CLR/RAMP3). " 11/15/2009 - "Adrenomedullin (AM), a multifunctional peptide, is highly expressed in several tumors and plays an important role in angiogenesis and tumor growth through its receptors: calcitonin receptor-like receptor/receptor activity-modifying protein 2 and 3 (CLR/RAMP2 and CLR/RAMP3). " 01/01/2016 - "Adrenomedullin (AM) is a multifunctional peptide that is highly expressed in several tumors and plays an important role in angiogenesis and tumor growth after binding to its receptors, calcitonin receptor-like receptor/receptor activity-modifying protein 2 (CLR/RAMP2) and calcitonin receptor-like receptor/receptor activity-modifying protein 3 (CLR/RAMP3). "

Related Drugs and Biologics

1.	Adrenomedullin
2.	Calcitonin Receptor-Like Protein
3.	Messenger RNA (mRNA)
4.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
5.	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
6.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
7.	Peptides (Polypeptides)
8.	Receptor Activity-Modifying Protein 3
9.	Calcitonin Receptors (Calcitonin Receptor)
10.	Long Noncoding RNA