Receptor Activity-Modifying Proteins

A family of proteins that bind to CELL SURFACE RECEPTORS and alter their specificity, signaling mechanism, or mode of intracellular transport.

Also Known As:

RAMP Receptor Accessory Proteins; Receptor Activity-Modifying Protein; Receptor Activity Modifying Protein; Receptor Activity Modifying Proteins

Networked: 31 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Receptor Activity-Modifying Proteins: 31
  - Intracellular Signaling Peptides and Proteins: 32
    - Signal Transducing Adaptor Proteins
      - Receptor Activity-Modifying Proteins: 31
        Receptor Activity-Modifying Protein 1: 29
        Receptor Activity-Modifying Protein 2: 19
        Receptor Activity-Modifying Protein 3: 5

Experts

1.	Tsujikawa, Kazutake: 3 articles (01/2020 - 10/2007)
2.	Kitamura, Kazuo: 2 articles (09/2011 - 12/2004)
3.	Fukada, So-ichiro: 2 articles (06/2011 - 10/2007)
4.	Kato, Tetsuya: 2 articles (06/2011 - 10/2007)
5.	Matsushita, Hiroaki: 2 articles (06/2011 - 10/2007)
6.	Ogitani, Yusuke: 2 articles (06/2011 - 10/2007)
7.	Yamamoto, Hiroshi: 2 articles (06/2011 - 10/2007)
8.	Zhang, Jing: 2 articles (06/2010 - 10/2006)
9.	Murakami, O: 2 articles (11/2001 - 12/2000)
10.	Takahashi, K: 2 articles (11/2001 - 12/2000)

Related Diseases

1.	Heart Failure 08/01/2004 - "[Increased atria expression of receptor activity-modifying proteins in heart failure patients]." 09/01/2008 - "To investigate the pathophysiological role of AM2/IMD in heart failure, we examined the expression of AM2/IMD, adrenomedullin (AM) and receptor complex components (calcitonin receptor-like receptor, three types of receptor activity-modifying proteins) by quantitative RT-PCR and immunohistochemistry in the hearts and kidneys of rats with congestive heart failure (CHF). " 12/01/2000 - "Increased gene expression of adrenomedullin and adrenomedullin-receptor complexes, receptor-activity modifying protein (RAMP)2 and calcitonin-receptor-like receptor (CRLR) in the hearts of rats with congestive heart failure." 12/01/2000 - "A novel adrenomedullin receptor complex has recently been identified, namely the calcitonin receptor-like receptor (CRLR) and receptor-activity modifying protein (RAMP) 2. In the present study, we have examined gene expression of RAMP2, CRLR and adrenomedullin in hearts and kidneys of rats with congestive heart failure caused by coronary artery ligation. "
2.	Hypoxia (Hypoxemia) 04/01/2007 - "In RPAEC, both high AM and hypoxia down-regulated receptor activity-modifying protein (RAMP)1, but they up-regulated RAMP2 protein and AM receptor sites, and RAMP2 silencing by small interference RNA proved its pivotal role for signal switching. " 11/01/2001 - "Differential expression of adrenomedullin and its receptor component, receptor activity modifying protein (RAMP) 2 during hypoxia in cultured human neuroblastoma cells." 04/25/2007 - "The purpose of the present study was to explore the expression changes of intermedin/adrenomedullin 2 (IMD/ADM2), a novel small molecular bioactive peptide, and its receptors, calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMP1, RAMP2, RAMP3) in the right ventricle of rats with chronic hypoxia-induced pulmonary hypertension. " 11/01/2001 - "Recently, a novel adrenomedullin receptor has been identified as a complex consisting of calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein (RAMP) 2. To explore possible pathophysiological roles of adrenomedullin and its receptor component RAMP2 in hypoxic tissues, we studied effects of hypoxia on expression of adrenomedullin and RAMP2 in two human neuroblastoma cell lines, IMR-32 and NB69, by radioimmunoassay and Northern blot analysis. "
3.	Pulmonary Hypertension 04/25/2007 - "The purpose of the present study was to explore the expression changes of intermedin/adrenomedullin 2 (IMD/ADM2), a novel small molecular bioactive peptide, and its receptors, calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMP1, RAMP2, RAMP3) in the right ventricle of rats with chronic hypoxia-induced pulmonary hypertension. "
4.	Stroke (Strokes) 11/30/2007 - "Unaltered mRNA expression of calcitonin-like receptor and receptor activity modifying proteins in human arteries in stroke and myocardial infarction." 01/15/2005 - "We studied three groups: control Wistar Kyoto rats (WKY), spontaneously hypertensive stroke-prone rats (SHR-SP), and diuretic-treated SHR-SP. We measured AM-mature, active form, and AM-total (active form+inactive form) in plasma and renal tissues, and mRNA levels of AM and AM receptor system components such as calcitonin receptor-like receptor (CRLR), receptor activity-modifying protein (RAMP) 2, and RAMP3 in renal tissues. "
5.	Myocardial Ischemia (Ischemic Heart Diseases) 03/01/2013 - "We aimed to explore the protein expression of IMD and its receptors, calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs), and the role of endogenous IMD in myocardial ischemia/reperfusion (I/R) injury in rats. " 01/01/2008 - "Chronic inhibition of nitric oxide (NO) synthesis is associated with hypertension, myocardial ischemia, oxidative stress and hypertrophy; expression of adrenomedullin (AM) and intermedin (IMD) and their receptor activity modifying proteins (RAMPs 1-3) is augmented in cardiomyocytes, indicating that the myocardial AM/ IMD system may be activated in response to pressure loading and ischemic insult. "

Related Drugs and Biologics

1.	Adrenomedullin
2.	Calcitonin Receptor-Like Protein
3.	Calcitonin Receptors (Calcitonin Receptor)
4.	Adrenomedullin Receptors
5.	Peptides (Polypeptides)
6.	Messenger RNA (mRNA)
7.	Proteins (Proteins, Gene)
8.	Calcitonin Gene-Related Peptide
9.	Calcitonin Gene-Related Peptide Receptors (Calcitonin-Gene Related Peptide Receptor)
10.	Islet Amyloid Polypeptide Receptors

Related Therapies and Procedures

1.	Ligation