Necrobiotic Xanthogranuloma

A cutaneous necrobiotic disorder characterized by firm, yellow plaques or nodules, often in a periorbital distribution. It is often accompanied by an elevated ERYTHROCYTE SEDIMENTATION RATE; LEUKOPENIA; and MONOCLONAL GAMMOPATHY (IgG-kappa type) and systemic involvement.
Also Known As:
Necrobiotic Xanthogranulomas; Xanthogranuloma, Necrobiotic; Xanthogranulomas, Necrobiotic
Networked: 63 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neurologic Manifestations (Neurological Manifestations)
2. Paraproteinemias (Monoclonal Gammopathy)
3. Necrobiosis Lipoidica
4. Multiple Myeloma
5. Granuloma


1. Ziemer, Mirjana: 2 articles (09/2010 - 09/2005)
2. Barrett, Terry L: 2 articles (07/2004 - 05/2004)
3. Lynch, Jane M: 2 articles (07/2004 - 05/2004)
4. Chave, T A: 2 articles (09/2001 - 01/2001)
5. Kindle, Scott A: 1 article (04/2015)
6. Hart, Philip A: 1 article (04/2015)
7. Chari, Suresh T: 1 article (04/2015)
8. Lehman, Julia S: 1 article (04/2015)
9. Smyrk, Thomas C: 1 article (04/2015)
10. Pittelkow, Mark R: 1 article (04/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Necrobiotic Xanthogranuloma:
1. Prednisolone (Predate)FDA LinkGeneric
2. Melphalan (Alkeran)FDA LinkGeneric
3. InterferonsIBA
4. Ficusin (Psoralen)IBA
5. Immunoglobulin G (IgG)IBA
6. Immunoglobulins (Immunoglobulin)IBA
7. Dexamethasone (Maxidex)FDA LinkGeneric
8. Immunoglobulin A (IgA)IBA
9. CholesterolIBA
02/01/1988 - "When cholesterol clefts are seen in biopsy specimens of necrobiosis, necrobiotic xanthogranuloma must be ruled out. "
02/01/1988 - "Necrobiosis lipoidica diabeticorum with cholesterol clefts in the differential diagnosis of necrobiotic xanthogranuloma."
05/01/1995 - "Necrobiotic xanthogranuloma is a rare disease marked by yellowish-brown plaques with destructive growth and a tendency to ulceration, which shows a characteristic histopathological pattern of palisading granuloma with foam cells, Touton's and foreign-body giant cells, bizarre multinuclear giant cells, cholesterol clefts and marked necrobiosis of the connective tissue. "
01/15/2001 - "A skin biopsy specimen showed a granulomatous infiltrate consisting of lymphocytes, histiocytes, plasma cells, foam cells as well as Touton and bizarre-appearing foreign-body giant cells and cholesterol clefts typical of necrobiotic xanthogranuloma besides a deposit of amyloid. "
10/01/2000 - "Histopathologic examination showed all the major features of a necrobiotic xanthogranuloma (NX) involving the entire dermis and subcutis, including areas of necrobiosis with cholesterol clefts, granulomatous infiltrate with some bizarre giant cells, numerous Touton cells, foamy cells, lymphoid follicles with germinal centers, foci of plasma cells, and "Touton cell panniculitis." A laboratory investigation revealed only slightly increased titers of cholesterol, strong positivity of anti-Borrelia antibodies, and diffuse skeletal osteoporosis with fractures of seven vertebrae. "
10. Chlorambucil (Leukeran)FDA Link

Therapies and Procedures

1. Plasmapheresis
2. Drug Therapy (Chemotherapy)
3. Stem Cell Transplantation
4. Blepharoplasty
5. Transplants (Transplant)