Loose Anagen Hair Syndrome

Benign childhood alopecia that improves spontaneously with aging. It is characterized by anagen hairs (misshapen hair bulbs and absent inner and outer root sheaths), thin, and sparse hairs that pulls out easily.

Also Known As:

Networked: 15 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Alopecia (Baldness)
2.	Monilethrix
3.	Menkes Kinky Hair Syndrome (Menkes Disease)
4.	Alopecia Areata
5.	Netherton Syndrome

Experts

1.	Piérard, G E: 1 article (12/2014)
2.	Piérard-Franchimont, C: 1 article (12/2014)
3.	Chandran, Nisha S: 1 article (05/2014)
4.	Oranje, Arnold P: 1 article (05/2014)
5.	Rossi, A: 1 article (02/2014)
6.	Calvieri, S: 1 article (02/2014)
7.	Newell, Brandon: 1 article (01/2014)
8.	Shao, Lei: 1 article (01/2014)
9.	Greenlaw, Sheila: 1 article (09/2012)
10.	Wiss, Karen: 1 article (09/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Loose Anagen Hair Syndrome:

1.	Minoxidil (Rogaine)FDA LinkGeneric 05/01/2014 - "A 2-year-old girl with a diagnosis of loose anagen hair syndrome was treated with a tapering regime of minoxidil 5% solution over 28 months, resulting in quick, significant clinical improvement with no adverse effects. " 05/01/2014 - "Minoxidil 5% solution for topical treatment of loose anagen hair syndrome."
2.	Uncombable hair syndromeIBA 05/01/2005 - "The occurrence of both syndromes in the same patient seems unlikely, and we propose that our patient has loose anagen hair syndrome with features resembling uncombable hair syndrome." 02/01/1996 - "Hair pull specimens, diagnostic for loose anagen hair syndrome, also showed hair shaft abnormalities described in the uncombable hair syndrome. " 02/01/1996 - "Loose anagen hair syndrome mimicking the uncombable hair syndrome." 01/01/2014 - "Thirty-seven patients (31%) showed morphologic changes compatible with specific diagnoses of various genetic conditions, including 25 cases of loose anagen hair syndrome, 6 cases of uncombable hair syndrome, 2 cases of Netherton syndrome, 3 cases of Menkes syndrome, and 1 case of trichothiodystrophy. " 01/01/2014 - "Examples of genetic disorders with associated hair abnormalities include Menkes syndrome, Netherton syndrome, uncombable hair syndrome, trichothiodystrophy, and loose anagen hair syndrome. "
3.	TrichothiodystrophyIBA 12/01/2005 - "In 25%, the changes were compatible with specific diagnoses including Menkes disease, Netherton's syndrome, trichothiodystrophy, Griscelli and Chediak-Higashi syndromes, monilethrix, uncombable hair, and loose anagen syndromes. " 01/01/2014 - "Thirty-seven patients (31%) showed morphologic changes compatible with specific diagnoses of various genetic conditions, including 25 cases of loose anagen hair syndrome, 6 cases of uncombable hair syndrome, 2 cases of Netherton syndrome, 3 cases of Menkes syndrome, and 1 case of trichothiodystrophy. " 01/01/2014 - "Examples of genetic disorders with associated hair abnormalities include Menkes syndrome, Netherton syndrome, uncombable hair syndrome, trichothiodystrophy, and loose anagen hair syndrome. " 02/01/2014 - "Congenital abnormalities of the hair shaft that present an increased fragility of hair include: Trichorrhexis nodosa congenita, Trichoschisis, Trichorrhexis invaginata, Trichothiodystrophy, Trichoclasia, Pili torti, Monilethrix and Loose anagen syndrome; while the alterations that are not associated with a greater fragility of the hair are: Pili annulati, Longitudinal grooves, Uncombable hair syndrome (Pili trianguli et canaliculi), Woolly hair, Woolly hair with dominant inheritance, Familial recessive woolly hair and Woolly hair nevus. "
4.	Keratins (Keratin)IBA 04/01/2002 - "Another keratin, and possibly the type I partner of K6hf, could be responsible for loose anagen hair syndrome in other patients, or the gene involved may be a minor gene." 04/01/2002 - "Is the loose anagen hair syndrome a keratin disorder? " 10/01/2001 - "In addition, this keratin represents a new candidate gene for inherited structural hair defects such as loose anagen syndrome."
5.	CosmeticsIBA 09/01/2009 - "Loose anagen hair syndrome: an unusual cause of alopecia of cosmetic importance only."
6.	Pili annulatiIBA 02/01/2014 - "Congenital abnormalities of the hair shaft that present an increased fragility of hair include: Trichorrhexis nodosa congenita, Trichoschisis, Trichorrhexis invaginata, Trichothiodystrophy, Trichoclasia, Pili torti, Monilethrix and Loose anagen syndrome; while the alterations that are not associated with a greater fragility of the hair are: Pili annulati, Longitudinal grooves, Uncombable hair syndrome (Pili trianguli et canaliculi), Woolly hair, Woolly hair with dominant inheritance, Familial recessive woolly hair and Woolly hair nevus. "
7.	Hypohidrotic Ectodermal DysplasiaIBA 01/01/1996 - "We report a 4 year-old boy affected with hypohidrotic ectodermal dysplasia in whom loose anagen hair syndrome (LAHS) was suspected clinically. "
8.	Ectrodactyly-cleft lip/palate syndromeIBA 03/01/2001 - "Other syndromes with hair abnormalities may also mimic uncombable hair syndrome clinically and these include, Rapp-Hodgkin ectodermal dysplasia; loose anagen hair syndrome; ectodermal dysplasia, ectrodatyly, cleft lip/palate (EEC) syndrome; and familial tricho-odonto-onchyial ectodermal dysplasia with syndactyly. "
9.	Dowling-Meara Epidermolysis bullosa herpetiformisIBA 09/01/2012 - "Loose anagen hair syndrome in two patients with epidermolysis bullosa simplex, Dowling-Meara type."
10.	Diffuse alopeciaIBA 12/01/2002 - "We review the 4 main diagnostic possibilities for this clinical scenario: (1) female pattern hair loss (androgenetic alopecia), (2) acute and chronic telogen effluvium, (3) diffuse alopecia areata, and (4) loose anagen syndrome. "

Therapies and Procedures

1.

Traction 12/01/2014 - "The main noncicatricial alopecias are represented by androgenetic alopecia, alopecia areata, trichotillomania, traction and pressure alopecia, temporal triangular alopecia, ageing alopecia, loose anagen syndrome, telogen effluvium and anagen effluvium." 01/01/2012 - "Most of the cases present initially to dermatologists with complaints of loss of hair and is often confused with other dermatological conditions like alopecia areata, tinea capitis, traction alopecia, and loose anagen syndrome. "