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Asymptomatic Diseases

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Diseases that do not exhibit symptoms.

Also Known As:

Asymptomatic Conditions; Asymptomatic States; Pre-Symptomatic Diseases; Presymptomatic Diseases; Asymptomatic Condition; Asymptomatic Disease; Asymptomatic State; Condition, Asymptomatic; Conditions, Asymptomatic; Disease, Asymptomatic; Disease, Pre-Symptomatic; Disease, Presymptomatic; Diseases, Asymptomatic; Diseases, Pre-Symptomatic; Diseases, Presymptomatic; Pre-Symptomatic Disease; Presymptomatic Disease

Networked: 198 relevant articles (12 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions
- Pathologic Processes: 4357
  - Disease Attributes: 2
    - Asymptomatic Diseases: 198
      - Asymptomatic Infections: 663

Related Diseases

1.	Infection
2.	Dyslipidemias (Dyslipidemia)
3.	Hypercalcemia (Milk Alkali Syndrome)
4.	HIV Infections (HIV Infection)
5.	Viremia

Experts

1.	Tagliavini, Fabrizio: 3 articles (03/2015 - 02/2012)
2.	Schnog, John-John B: 3 articles (10/2010 - 07/2008)
3.	Padovani, Alessandro: 2 articles (03/2015 - 02/2012)
4.	Sorbi, Sandro: 2 articles (03/2015 - 02/2012)
5.	Nacmias, Benedetta: 2 articles (03/2015 - 02/2012)
6.	Scarpini, Elio: 2 articles (03/2015 - 02/2012)
7.	Redaelli, Veronica: 2 articles (03/2015 - 01/2015)
8.	Nseir, William: 2 articles (03/2013 - 07/2012)
9.	Yue, Zhenyu: 2 articles (01/2012 - 07/2011)
10.	Teixeira-Carvalho, Andréa: 2 articles (04/2011 - 08/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Asymptomatic Diseases:

1.	Biological Markers (Surrogate Marker)IBA 12/01/2010 - "At present, we have no definitive diagnostic test, and thus for clinicians there is still expectation that biomarkers will eventually help to diagnose symptomatic and presymptomatic disease, or provide surrogated end-points to demonstrate clinical efficacy of new treatments and neuroprotective therapies. " 08/01/2004 - "We currently have no definitive diagnostic test, and thus for the clinician there is hope that biomarkers will help diagnose symptomatic and presymptomatic disease or provide surrogate end-points to demonstrate clinical efficacy of new treatments, such as neuroprotective therapies, and help stratify this heterogeneous disease. " 12/01/2011 - "Data suggest that neuroimaging biomarkers will be useful as endpoints for trials in very early, even asymptomatic disease, though further work is necessary to establish validity for regulatory purposes." 09/01/2013 - "Besides showing a difference in biochemical markers between controls and the previously reported active-CHB case, the asymptomatic condition in both inactive- and active-CHB offers an excellent control for the patient's expectation about Guasha's efficacy. " 02/01/2012 - "However, the evidence about the instrumental and laboratory markers for the diagnosis of the preclinical and asymptomatic states of the disease are, until to now, insufficient to support the routine clinical use of these investigations."
2.	Zidovudine (Retrovir)FDA LinkGeneric 04/01/1992 - "Whether zidovudine is indicated for early asymptomatic disease when CD4 counts are below 500 microliters-1 is controversial. " 04/20/1991 - "The efficacy of zidovudine was demonstrated in patients with symptomatic HIV infection as well as in patients with advanced asymptomatic disease. " 08/10/1994 - "Zidovudine at 500 mg/d caused a significant delay in progression to AIDS or death, but its earlier use in asymptomatic disease was not associated with an additional prolongation of survival compared with delayed initiation. "
3.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 04/01/2009 - "Sequential evaluation of serum monocyte chemotactic protein 1 among asymptomatic state and acute exacerbation and remission of asthma in children."
4.	Gemfibrozil (Lopid)FDA LinkGeneric 05/01/1993 - "The once-daily formulation of gemfibrozil may afford better control of dyslipidemia through improved compliance by patients who have this asymptomatic disease."
5.	MetanephrineIBA 01/01/1989 - "The urine metanephrine was markedly elevated in the asymptomatic state compared to controls, but remained unchanged during the attacks, again suggesting defective renal clearance of metanephrine. "
6.	MercuryIBA 01/01/2002 - "It is concluded that prophylactic therapy in the presence of toxic levels of mercury, despite the presence of an asymptomatic state in exposed residents, is effective in preventing the development of signs and symptoms, though instruction of high-risk cases is the best way to combat it."
7.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 12/15/1998 - "Clinical trials that have studied or are currently studying asymptomatic disease include: the Carotid Artery Stenosis with Asymptomatic Narrowing Operation Versus Aspirin study; the Mayo Asymptomatic Carotid Endarterectomy trial; Veterans Administration Cooperative Trial on Asymptomatic Carotid Stenosis; and the Asymptomatic Carotid Atherosclerosis Study. " 05/15/2009 - "We performed a post hoc analysis of the CHARISMA trial, which randomly assigned patients without active acute coronary syndrome, but with established atherosclerotic disease (symptomatic) or multiple risk factors for atherosclerotic disease (asymptomatic), to clopidogrel plus aspirin versus placebo plus aspirin. "
8.	DNA (Deoxyribonucleic Acid)IBA 03/01/1990 - "The recent identification of genetic lesions that cause this disorder further demonstrates the remarkable clinical benefits that may accrue from the study of the molecular basis of inherited diseases and its population genetics: it is now possible to detect asymptomatic disease carriers and diagnose the disorder in affected families by non-invasive analysis of small samples of genomic DNA. " 05/01/2003 - "Prevalence of C pneumoniae DNA in PBMCs was significantly higher in patients with symptomatic disease (72.2%) compared with those with asymptomatic disease (30.3%) (P =.01). " 05/01/2003 - "C pneumoniae DNA in lymph nodes was detected in 33.3% of patients with symptomatic disease and 18.2% of those with asymptomatic disease (P =.19). " 05/01/2003 - "C pneumoniae DNA in atherosclerotic carotid plaques was detected in 44.4% of patients with symptomatic disease and in 30.3% of those with asymptomatic disease (P =.48). " 12/01/1995 - "The B-lymphotrophic human herpes Epstein-Barr virus (EBV) is a 160-kilobase double-stranded DNA episomal virus carried in a persistent asymptomatic state by more than 90% of the worldwide adult population. "
9.	CytokinesIBA 10/01/2012 - "The maintenance of the asymptomatic state is now recognized as reflecting an immunoregulatory environment, which may be promoted by parasites, and involves multiple levels of host regulatory cells and cytokines; a breakdown of this regulation is observed in pathological disease. " 05/01/1998 - "Multiparameter analysis of clastogenic factors, pro-oxidant cytokines, and inflammatory markers in HIV-1-infected patients with asymptomatic disease, opportunistic infections, and malignancies." 05/01/1998 - "The aim of this clinical study was to compare levels of CF in HIV-1-positive patients with asymptomatic disease, opportunistic infections, and malignancies with those in HIV-1-negative control groups and to correlate CF activity with CD4+ T cell numbers, the cytokines (TNF-alpha, interleukin-2 [IL-2], IL-6), and the inflammatory markers (C-reactive protein [CRP], neopterin, granulocyte elastase). "
10.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 05/28/2010 - "We have found that middle cerebral artery disease confers a lower mortality than vessel-specific ICAD in other intracranial vessels, asymptomatic disease follows a more benign course than symptomatic disease, and that plaque progression or the detection of microemboli on transcranial Doppler may predict poor outcome. " 09/01/2006 - "Here, we outline a proposed treatment algorithm, outlining therapeutic alternatives: (1) PEA should be considered as the first treatment option, where possible; (2) medical intervention is a possible option in inoperable patients and those with significant arteriopathy, although only chronic anticoagulation has been widely used to date (advanced medical treatment options could include prostanoids, endothelin receptor antagonists, or phosphodiesterase-5 inhibitors, but randomized clinical trials are required); (3) pulmonary hypertension is likely to persist after PEA in patients with significant small-vessel arteriopathy, resulting in poor clinical outcome and increased perioperative mortality (medical therapy could also be applied here); (4) anticoagulation therapy and, possibly, advanced medical treatment with careful monitoring may provide benefits in patients with mild or asymptomatic disease; (5) if medical therapy begins to fail, PEA should be offered without delay to avoid progression to severe, secondary arteriopathy; (6) in the absence of severe comorbidity, lung transplantation may be undertaken where PEA has failed, in nonresponders to medical therapy, and in patients with progressive arteriopathy; (7) in patients not eligible for PEA due to collateral and/or surgically inaccessible lesions, balloon angioplasty may be a possible alternative at some centers, but is experimental and requires further assessment. "

Therapies and Procedures

1.	Thymectomy 03/01/2011 - ": Right VATS thymectomy achieves comparable remission and asymptomatic disease rates to other minimally invasive and open techniques when compared with studies using either MGFA or older criteria." 03/01/2011 - "Our aim was to assess the complete stable remission and asymptomatic disease rates after VATS thymectomy in nonthymomatous myasthenia gravis. " 08/01/2009 - "Although the MG patients with atrophy of type II fibres did not differ from the remaining MG cases in terms of improvement in the disease during the follow-up period, our analysis provides clear evidence that they presented a significantly slower tendency to reach an asymptomatic state after thymectomy. " 02/01/1983 - "Eleven of 16 patients with symptomatic MG had an increased number of T lymphocytes bearing surface thymosin alpha 1 (T alpha 1); 5 patients with asymptomatic disease had normal levels of T alpha 1. In six young adults with symptomatic MG who subsequently responded to thymectomy, the number of T alpha 1 cells returned to normal 1 month after thymectomy. "
2.	Parathyroidectomy 01/01/1997 - "Subtotal parathyroidectomy was performed at 6 wk; hypercalcemia recurred rapidly but the bone disease improved gradually with reversion to an asymptomatic state resembling familial benign hypocalciuric hypercalcemia (FBHH). "
3.	Transplantation (Transplant Recipients) 07/01/2015 - "We identified 393 kidney transplant recipients who were readmitted to Barnes-Jewish Hospital in St. Louis, Missouri from January 1, 2007 to December 31, 2011 to determine the accuracy of the ICD-9-CM diagnosis code for CMV (078.5) in identifying active CMV infection or disease (asymptomatic viremia, CMV syndrome, or tissue-invasive CMV disease) in the inpatient setting, using microbiological, histopathologic, or ophthalmologic evidence for CMV as the gold standard. "
4.	Myocardial Revascularization 09/01/1981 - "Thus complete myocardial revascularization is superior to incomplete revascularization in terms of survival and asymptomatic state. "
5.	Carotid Endarterectomy 12/01/1999 - "Randomized clinical trials have provided us with clinical guidelines regarding the indications for performing carotid endarterectomy in patients who have symptomatic and asymptomatic disease. " 06/01/2009 - "Although there is level I evidence supporting the role of carotid endarterectomy (CEA) in patients with asymptomatic disease, opinion remains polarised regarding what constitutes optimal management, especially as carotid artery stenting (CAS) has emerged as a less invasive alternative. " 07/01/2006 - "Eighty-four consecutive patients undergoing carotid endarterectomy for symptomatic and asymptomatic disease were studied. " 02/01/2004 - "We retrospectively reviewed concordance of findings of carotid duplex ultrasound scanning between laboratories accredited by the Intersocietal Commission for Accreditation of Vascular Laboratories and nonaccredited laboratories in 174 patients with asymptomatic disease referred to tertiary care community hospitals for surgical evaluation for carotid endarterectomy (CEA) between January 2001 and December 2002, and evaluated changes in clinical management made on the basis of repeat examinations. " 05/01/2003 - "Fifty-one consecutive patients undergoing carotid endarterectomy were enrolled; 18 of the 51 patients had symptomatic disease, whereas 33 had asymptomatic disease. "