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Intraventricular Infusions

Subscribe to New Research on Intraventricular Infusions

The delivery of a drug into a fluid-filled cavity of the brain.

Also Known As:

Infusions, Intraventricular; Infusions, Intracerebroventricular; Infusion, Intracerebroventricular; Infusion, Intraventricular; Intracerebroventricular Infusion; Intracerebroventricular Infusions; Intraventricular Infusion

Networked: 276 relevant articles (17 outcomes, 29 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 15318
- Drug Therapy: 178671
  - Drug Administration Routes: 9
    - Parenteral Infusions: 186
      - Intraventricular Infusions: 276

Experts

1.	Ishihara, Akane: 7 articles (06/2009 - 03/2003)
2.	Iwaasa, Hisashi: 7 articles (06/2009 - 03/2003)
3.	Kanatani, Akio: 7 articles (06/2009 - 03/2003)
4.	Leenen, Frans H H: 6 articles (08/2014 - 05/2004)
5.	Folbergrová, Jaroslava: 6 articles (01/2012 - 03/2003)
6.	Ito, Makoto: 6 articles (01/2010 - 03/2003)
7.	Haugvicová, Renata: 5 articles (02/2010 - 03/2003)
8.	Mashiko, Satoshi: 5 articles (06/2009 - 03/2003)
9.	Zhang, Guang-Yi: 5 articles (12/2005 - 06/2003)
10.	Huang, Bing S: 4 articles (08/2014 - 02/2005)

Related Diseases

1.	Seizures (Seizure) 01/10/2007 - "Intraventricular infusions of PPA produced reversible repetitive dystonic behaviours, hyperactivity, turning behaviour, retropulsion, caudate spiking, and the progressive development of limbic kindled seizures, suggesting that this compound has central effects. " 03/01/2003 - "Seizures were induced by bilateral intracerebroventricular infusion of HCA (600 nmol per each side) in 12-day-old rats. " 01/02/1997 - "Intracerebroventricular infusion of the peptide both 30 min before and 10 min after seizures decreased damage in some hippocampal cell fields by as much as 84%, a magnitude of protection greater than reported for other CRF antagonists against other models of necrotic neuronal injury. " 04/01/2007 - "The major finding of the present study concerns the marked decrease of respiratory chain complex I activity in the cerebral cortex of immature rats following seizures induced by bilateral intracerebroventricular infusion of dl-homocysteic acid (600 nmol/side). " 02/01/2010 - "Our previous work demonstrated the marked decrease of mitochondrial complex I activity in the cerebral cortex of immature rats during the acute phase of seizures induced by bilateral intracerebroventricular infusion of dl-homocysteic acid (600 nmol/side) and at short time following these seizures. "
2.	Brain Ischemia (Cerebral Ischemia) 01/01/2012 - "Stereotactic coordinates for intracerebroventricular infusion after permanent focal cerebral ischemia in Wistar rats." 09/12/1997 - "In rats with a single or continuous intraventricular infusion of CHX, starting just after brain ischemia, in the VP thalamic neurons were significantly more numerous than those in the thalamic nucleus of rats with vehicle infusion at 1 week after MCA occlusion. " 01/01/2014 - "We investigated whether intraventricular infusion of PEDF reduces infarct size and cell death, ameliorates behavioral outcome, and influences cell proliferation in the one-hour middle cerebral artery occlusion (MCAO) mouse model of focal cerebral ischemia. " 12/01/2015 - "In this study, we investigated whether combining delayed hypothermia with connexin hemichannel blockade with intracerebroventricular infusion of a mimetic peptide can further improve outcomes after cerebral ischemia. " 03/28/2008 - "l-3-n-Butylphthalide (l-NBP), as an anti-cerebral ischemia agent, has been shown to have therapeutic effects on learning and memory deficits induced by chronic cerebral hypoperfusion and Abeta intracerebroventricular infusion in rats. "
3.	Body Weight (Weight, Body) 01/01/2012 - "The intracerebroventricular infusion of NPW has been shown to suppress food intake and body weight and to increase both heat production and body temperature, suggesting that NPW functions as an endogenous catabolic signaling molecule. " 01/17/2007 - "We studied the feasibility of using the conjugates for in vivo magnetic resonance imaging (MRI) to monitor gene transcription, and demonstrated that these complexes at 40 mug of Fe per kilogram of body weight were retained at least 1 d after intracerebroventricular infusion into the left ventricle of C57Black6 mice. " 04/01/2006 - "Hypothalamic BEACON gene expression was positively correlated with percentage of body fat, and intracerebroventricular infusion of the Beacon protein resulted in a dose-dependent increase in food intake and body weight. " 07/01/2005 - "Chronic intracerebroventricular infusion of the MCH1R antagonist (7.5 microg/d) completely suppressed body weight gain in diet-induced obese mice during the treatment periods and significantly decreased cumulative food intake, by 14%. " 03/01/2003 - "Intracerebroventricular infusion of MCH (10 microg/day for 14 days) caused a slight but significant increase in body weight in mice maintained on the regular diet. "
4.	Hypertension (High Blood Pressure) 02/01/2005 - "These findings indicate that in Dahl S rats, intracerebroventricular infusion of Aldo causes similar central responses as high salt intake, i.e., increases in brain OLC content, sympathetic hyperreactivity, and hypertension. " 06/01/1995 - "Intracerebroventricular infusion studies have shown that aldosterone occupancy of such unprotected circumventricular MR is necessary for mineralocorticoid hypertension, and the hypertensinogenic effects of peripherally infused aldosterone can be blocked by intracerebroventricular infusion of the MR antagonist RU28318. " 03/01/2015 - "We also pre-treated CPO-mice with an intracerebroventricular infusion of miso supernatant to evaluate its effect on increased cerebrospinal fluid (CSF) sodium-induced hypertension. " 02/01/2015 - "Intracerebroventricular infusion of PRO20 dose-dependently inhibited prorenin-induced hypertension in C57Bl6/J mice. " 11/15/2013 - "An experimental model of neurogenic hypertension that employed intracerebroventricular infusion of angiotensin II in male adult C57BL/6 mice was used. "
5.	Alzheimer Disease (Alzheimer's Disease) 01/01/1994 - "Continuous intraventricular infusion of GM1 has recently been shown to have a significant beneficial effect in Alzheimer disease of early onset (AD Type I)." 11/01/1986 - "Transmitter-replacement therapy in Alzheimer's disease using intracerebroventricular infusions of receptor agonists." 01/01/2000 - "A clinical study in three patients with Alzheimer disease revealed, however, that a long-term intracerebroventricular infusion of nerve growth factor may have certain potentially beneficial effects, but the continuous intracerebroventricular route of administration is also associated with negative side effects that appear to outweigh the positive effects. " 01/01/2009 - "Increased expression of PAD2 after repeated intracerebroventricular infusions of soluble Abeta(25-35) in the Alzheimer's disease model rat brain: effect of memantine." 04/01/2006 - "Using a human amyloid beta (Abeta) intracerebroventricular infusion mouse model of Alzheimer's disease-related injury, we previously demonstrated that systemic administration of a glial activation inhibitor could suppress neuroinflammation, prevent synaptic damage, and attenuate hippocampal-dependent behavioral deficits. "

Related Drugs and Biologics

1.	homocysteic acid
2.	Brain-Derived Neurotrophic Factor (BDNF)
3.	Amyloid (Amyloid Fibrils)
4.	Quinine (Quinson)
5.	Kainic Acid (Kainate)
6.	Renin
7.	Ibuprofen (Motrin)
8.	Streptokinase
9.	Interleukins
10.	Curcumin

Related Therapies and Procedures

1.	Palliative Care (Palliative Medicine)
2.	Catheters
3.	Ventriculostomy
4.	Subcutaneous Infusions
5.	Intravenous Injections