Intraventricular Infusions

The delivery of a drug into a fluid-filled cavity of the brain.

Also Known As:

Infusions, Intraventricular; Infusions, Intracerebroventricular; Infusion, Intracerebroventricular; Infusion, Intraventricular; Intracerebroventricular Infusion; Intracerebroventricular Infusions; Intraventricular Infusion

Networked: 355 relevant articles (19 outcomes, 38 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Drug Administration Routes: 28
    - Parenteral Infusions: 228
      - Intraventricular Infusions: 355

Experts

1.	Ishihara, Akane: 7 articles (06/2009 - 03/2003)
2.	Iwaasa, Hisashi: 7 articles (06/2009 - 03/2003)
3.	Kanatani, Akio: 7 articles (06/2009 - 03/2003)
4.	Leenen, Frans H H: 6 articles (08/2014 - 05/2004)
5.	Folbergrová, Jaroslava: 6 articles (01/2012 - 03/2003)
6.	Ito, Makoto: 6 articles (01/2010 - 03/2003)
7.	Bennet, Laura: 5 articles (09/2020 - 01/2014)
8.	Davidson, Joanne O: 5 articles (09/2020 - 01/2014)
9.	Gunn, Alistair J: 5 articles (09/2020 - 01/2014)
10.	Haugvicová, Renata: 5 articles (02/2010 - 03/2003)

Related Diseases

1.	Seizures (Absence Seizure) 01/10/2007 - "Intraventricular infusions of PPA produced reversible repetitive dystonic behaviours, hyperactivity, turning behaviour, retropulsion, caudate spiking, and the progressive development of limbic kindled seizures, suggesting that this compound has central effects. " 03/01/2003 - "Seizures were induced by bilateral intracerebroventricular infusion of HCA (600 nmol per each side) in 12-day-old rats. " 01/01/2019 - "Intracerebroventricular infusion of Hm1a rescues Dravet syndrome mice from seizures and premature death. " 01/01/2018 - "Intracerebroventricular infusion of Hm1a rescues Dravet syndrome mice from seizures and premature death. " 04/01/2007 - "The major finding of the present study concerns the marked decrease of respiratory chain complex I activity in the cerebral cortex of immature rats following seizures induced by bilateral intracerebroventricular infusion of dl-homocysteic acid (600 nmol/side). "
2.	Alzheimer Disease (Alzheimer's Disease) 01/01/1994 - "Continuous intraventricular infusion of GM1 has recently been shown to have a significant beneficial effect in Alzheimer disease of early onset (AD Type I)." 11/01/1986 - "Transmitter-replacement therapy in Alzheimer's disease using intracerebroventricular infusions of receptor agonists." 02/25/2016 - "In the present study, we report that an intracerebroventricular infusion of NRG1 attenuated cognitive impairments in 13-month-old Tg2576 mice, an animal model of Alzheimer's disease (AD). " 01/01/2018 - "Intraventricular infusion of clusterin ameliorated cognition and pathology in Tg6799 model of Alzheimer's disease." 01/01/2009 - "Increased expression of PAD2 after repeated intracerebroventricular infusions of soluble Abeta(25-35) in the Alzheimer's disease model rat brain: effect of memantine."
3.	Brain Ischemia (Cerebral Ischemia) 01/01/2012 - "Stereotactic coordinates for intracerebroventricular infusion after permanent focal cerebral ischemia in Wistar rats." 09/12/1997 - "In rats with a single or continuous intraventricular infusion of CHX, starting just after brain ischemia, in the VP thalamic neurons were significantly more numerous than those in the thalamic nucleus of rats with vehicle infusion at 1 week after MCA occlusion. " 01/01/2014 - "We investigated whether intraventricular infusion of PEDF reduces infarct size and cell death, ameliorates behavioral outcome, and influences cell proliferation in the one-hour middle cerebral artery occlusion (MCAO) mouse model of focal cerebral ischemia. " 03/01/2000 - "Intraventricular infusion of apolipoprotein E ameliorates acute neuronal damage after global cerebral ischemia in mice." 03/01/2002 - "The purpose of this study was to assess the angiogenic and capillary permeability effects of chronic intraventricular infusion of exogenous VEGF in nonischemic brain tissue, because many patients with impaired cerebrovascular reserve do not exhibit chronic cerebral ischemia. "
4.	Cognitive Dysfunction 02/25/2016 - "In the present study, we report that an intracerebroventricular infusion of NRG1 attenuated cognitive impairments in 13-month-old Tg2576 mice, an animal model of Alzheimer's disease (AD). " 10/25/2009 - "In the present study, we investigated the potential of L-NBP to protect against cognitive impairment, oxidative damage and neuropathological changes induced by intracerebroventricular infusion of amyloid-beta peptide in rats. " 01/01/2023 - "Moreover, upregulation of hippocampal Nrf2 in aged rats with intracerebroventricular infusion of a Nrf2 activator reduced levels of ROS and proinflammatory cytokines in the hippocampus, ameliorating cognitive dysfunction after surgery. " 04/01/2010 - "Taken together, the present findings suggest that co-drug 1 treatment may protect against the cognitive dysfunction induced by intracerebroventricular infusion of beta-amyloid (1-40) in rats. " 10/25/2009 - "L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats."
5.	Body Weight (Weight, Body) 02/05/2017 - "Conversely, intracerebroventricular infusion of MCH caused induction of hepatic steatosis as well as increase in body weight in high-fat diet-fed wild type mice, but not MCH1 receptor knockout mice. " 01/01/2012 - "The intracerebroventricular infusion of NPW has been shown to suppress food intake and body weight and to increase both heat production and body temperature, suggesting that NPW functions as an endogenous catabolic signaling molecule. " 01/17/2007 - "We studied the feasibility of using the conjugates for in vivo magnetic resonance imaging (MRI) to monitor gene transcription, and demonstrated that these complexes at 40 mug of Fe per kilogram of body weight were retained at least 1 d after intracerebroventricular infusion into the left ventricle of C57Black6 mice. " 07/01/2005 - "Chronic intracerebroventricular infusion of the MCH1R antagonist (7.5 microg/d) completely suppressed body weight gain in diet-induced obese mice during the treatment periods and significantly decreased cumulative food intake, by 14%. " 03/01/2003 - "Intracerebroventricular infusion of MCH (10 microg/day for 14 days) caused a slight but significant increase in body weight in mice maintained on the regular diet. "

Related Drugs and Biologics

1.	homocysteic acid
2.	Salts
3.	Amyloid beta-Peptides
4.	Brain-Derived Neurotrophic Factor (BDNF)
5.	Interleukins
6.	Quinine (Quinson)
7.	Kainic Acid (Kainate)
8.	angiotensin I (1-7)
9.	Renin
10.	Ibuprofen (Motrin)

Related Therapies and Procedures

1.	Therapeutics
2.	Palliative Care (Palliative Therapy)
3.	Intravenous Administration
4.	Catheters
5.	Ventriculostomy