HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Drug Substitution

Subscribe to New Research on Drug Substitution

The practice of replacing one prescribed drug with another that is expected to have the same clinical or psychological effect.

Also Known As:

Drug Switching; Generic Substitution; Therapeutic Substitution; Drug Substitutions; Drug Switchings; Generic Substitutions; Substitution, Drug; Substitution, Generic; Substitution, Therapeutic; Substitutions, Drug; Substitutions, Generic; Substitutions, Therapeutic; Switching, Drug; Switchings, Drug; Therapeutic Substitutions

Networked: 128 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Sullivan, Sean D: 2 articles (09/2013 - 08/2009)
2.	Hansen, Ryan N: 2 articles (09/2013 - 08/2009)
3.	Walker, A Sarah: 2 articles (04/2013 - 02/2004)
4.	Shrank, William H: 2 articles (05/2012 - 03/2010)
5.	Toverud, Else-Lydia: 2 articles (02/2011 - 10/2009)
6.	Håkonsen, Helle: 2 articles (02/2011 - 10/2009)
7.	Endo, Yasuo: 2 articles (05/2010 - 05/2009)
8.	Kuroishi, Toshinobu: 2 articles (05/2010 - 05/2009)
9.	Yamaguchi, Kouji: 2 articles (05/2010 - 05/2009)
10.	Sugawara, Shunji: 2 articles (05/2010 - 05/2009)

Related Diseases

1.	Epilepsy (Aura) 04/01/2007 - "A prospective controlled evaluation of the safety and efficacy of generic substitution in epilepsy needs to be performed." 01/01/2013 - "Considerable concern exists among patients about generic substitution in the treatment of epilepsy. " 01/01/2013 - "We aimed to understand patient attitudes and perceptions about generic substitution in the treatment of epilepsy. " 01/01/2013 - "Generic substitution in the treatment of epilepsy: patient attitudes and perceptions." 02/01/2010 - "The issues surrounding generic drug substitution in patients with epilepsy are complex. "
2.	Seizures (Seizure) 01/01/2006 - "Therefore, generic substitution is not recommended in patients who achieved seizure remission. " 05/01/2001 - "The conversion design is a drug-substitution trial in which patients with uncontrolled seizures are assigned to add-on treatment with an investigational drug and, usually, an appropriate control, after which pre-existing treatment is gradually discontinued. " 09/01/2013 - "Bioequivalent antiepileptic drug switching and the risk of seizure-related events." 11/01/2011 - "The retrospective studies were categorized as Class III and showed a significant relationship between generic substitution and increased use of health care resources because of seizures or AED toxicity. " 04/01/2011 - "An increase in seizure frequency subsequent to generic substitution was associated with polytherapy compared to monotherapy (3.225; 1.512-6.880; p < 0.05). "
3.	Pain (Aches) 01/01/2014 - "Strenuous efforts should be put into obtaining good levels of pain relief for people in chronic pain, including the opportunity for multiple drug switching, using reliable, validated, and relatively easily applied patient-centered outcomes. " 05/01/2009 - "Inter and intraclass drug switching was high with 13% of PAIN MINUS DIAGNOSIS and 14% of PAIN PLUS DIAGNOSIS patients having three or more switches compared with 7% of NO PAIN patients. "
4.	Confusion (Bewilderment) 10/01/2009 - "This study shows that generic substitution can be an additional factor in poor drug adherence in hypertensive patients and contributes to concerns and confusion among the patients. " 06/01/2014 - "Generic substitution without adequate information resulted in confusion and subsequent lack of adherence. " 06/01/2014 - "Patients' knowledge of generic substitution practice, patients' report of abstaining from drug use, experiences of more side effects and patients' confusion. " 12/01/2012 - "Generic drug substitution reduces costs for medicines, but the downsides include unintentional double medication, confusion and anxiety among patients. " 08/01/1997 - ", generic substitution may cause confusion and anxiety in patients' minds when it occurs without prior warning. "
5.	Hypertension (High Blood Pressure) 09/01/2010 - "Effectiveness, safety and cost of drug substitution in hypertension." 04/01/2015 - "Potential savings in prescription drug costs for hypertension, hyperlipidemia, and diabetes mellitus by equivalent drug substitution in Austria: a nationwide cohort study." 05/01/1998 - "The measures that can influence the risk factors after an episode of myocardial infarction are briefly commented: characteristics related to life style and physical exercise; smoking habits; plasmatic lipid levels; high blood pressure; and therapeutic substitution with estrogens after menopause. " 04/01/2005 - "An open-label drug substitution study showed that controlled-release isradipine (Dynacirc-CR) can be safely substituted for amlodipine on a mg-for-mg basis in patients with mild-to-moderate hypertension. "

Related Drugs and Biologics

1.	Counterfeit Drugs
2.	Amlodipine (Norvasc)
3.	Isradipine (Dynacirc)
4.	Nitrates
5.	Clodronic Acid (Clodronate)
6.	onabotulinumtoxinA (Botox)
7.	abobotulinumtoxinA
8.	Anticonvulsants (Antiepileptic Drugs)
9.	Epoetin Alfa (Epogen)
10.	Stavudine (Zerit)

Related Therapies and Procedures

1.	Drug Substitution
2.	Drug Therapy (Chemotherapy)
3.	Dry Powder Inhalers
4.	Heart Transplantation (Grafting, Heart)
5.	Heterologous Transplantation (Xenotransplantation)