Striae Distensae

Linear dermal scars accompanied by epidermal atrophy that affects skin that is subjected to continuous stretching. They usually do not cause any significant medical problems, only cosmetic problems.

Also Known As:

Networked: 97 relevant articles (12 outcomes, 14 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cicatrix (Scar)
2.	Keloid
3.	Cellulitis
4.	Wounds and Injuries (Trauma)
5.	Phlebitis

Experts

1.	Strumia, Renata: 3 articles (01/2013 - 01/2005)
2.	Bayat, Ardeshir: 2 articles (09/2015 - 09/2013)
3.	Lee, Sang-Jun: 2 articles (12/2012 - 01/2007)
4.	Song, Kye-Yong: 2 articles (12/2012 - 01/2007)
5.	Suh, Dong-Hye: 2 articles (12/2012 - 01/2007)
6.	Vogt, Peter M: 2 articles (10/2010 - 04/2008)
7.	Hinek, Aleksander: 2 articles (10/2010 - 11/2005)
8.	Aust, Matthias C: 2 articles (10/2010 - 04/2008)
9.	Mitts, Thomas F: 2 articles (10/2010 - 11/2005)
10.	Muratori, G: 2 articles (09/2003 - 09/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Striae Distensae:

1.	Tretinoin (Retinoic Acid)FDA LinkGeneric 07/01/2001 - "In this small study, topical application of tretinoin significantly improved the clinical appearance of pregnancy-related stretch marks." 08/01/1994 - "Low-dose tretinoin does not improve striae distensae: a double-blind, placebo-controlled study." 02/01/2013 - "Transepidermal retinoic acid delivery using ablative fractional radiofrequency associated with acoustic pressure ultrasound for stretch marks treatment." 07/01/2001 - "In an open-label, multicenter, prospective study, 20 women applied tretinoin (retinoic acid) cream 0.1% daily for 3 months to pregnancy-related stretch marks in the abdominal area. " 05/01/1996 - "Topical application of tretinoin significantly improves the clinical appearance of early, active stretch marks. "
2.	NitrogenIBA 09/01/2003 - "Study results have shown that the use of MAP, in conjunction with the ANC/OMP, has proven to be safe and effective by preventing those adverse effects associated with a negative nitrogen balance, such as oversized or flabby tissue, stretch marks, sagging of breast tissue, increased hair loss, faded hair color, and fragile or brittle nails. " 09/01/2003 - "Study results have shown that the use of MAP, in conjunction with the ANC/OMP regimen, has proven to be safe and effective by preventing those adverse effects associated with a negative nitrogen balance, such as oversized or flabby tissue, stretch marks, the sagging of breast tissue, increased hair loss, faded hair color, and fragile or brittle nails. "
3.	Carbon MonoxideIBA 11/01/2011 - "These results support the use of nonablative fractional laser and ablative CO(2) fractional laser as effective and safe treatment modalities for striae distensae of Asian skin. " 11/01/2011 - "Although they do not statistically differ, both treatments with nonablative fractional laser and ablative CO(2) fractional laser showed a significant clinical and histopathologic improvement of striae distensae over pretreatment sites. " 11/01/2011 - "To assess and compare the efficacy and safety of nonablative fractional photothermolysis and ablative CO(2) fractional laser resurfacing in the treatment of striae distensae. " 11/01/2011 - "Treatment of Striae Distensae with Nonablative Fractional Laser versus Ablative CO(2) Fractional Laser: A Randomized Controlled Trial." 04/01/2011 - "The ablative CO(2) fractional laser is effective in various cutaneous scars and this study was attempted to evaluate the effect of succinylated atelocollagen and ablative CO(2) fractional laser in the treatment of striae distensae. "
4.	ElastinIBA 11/01/2005 - "Skin biopsies from normal subjects (NS), stretch-marked skin (SM), and normal-looking skin from patients with stretch marks (NL) were analyzed by histochemistry and assays of total protein, DNA, and elastin. " 08/01/1998 - "Analysis of these data reveals: 1) both regimens can improve the appearance of stretch marks; 2) these topical therapy regimens are safe and effective in study patients with minimal irritation; 3) elastin content within the reticular and papillary dermis can increase with topical 20% glycolic acid combined with 0.05% tretinoin emollient cream therapy; 4) both regimens increased epidermal thickness and decreased papillary dermal thickness in treated stretch marks when compared with untreated stretch marks; 5) combined epidermal and papillary dermal thickness in stretch marks treated with either topical regimen approaches that of normal skin; and 6) profilometry can objectively measure differences in skin texture associated with striae treatments when compared to controls, however, it is not sensitive enough to justify comparison or quantitative improvements between similarly effective treatments." 10/01/2010 - "Because aldosterone applied alone stimulates both collagen and elastin deposition in cultures of fibroblasts and in cultures of skin explants derived from dermal stretch marks, we postulate that this steroid should be used in the treatment of damaged skin that loses its volume and elasticity. " 07/01/1994 - "These observations suggest that expression of collagens, elastin and fibronectin genes are apparently decreased, and that there is a marked alteration of fibroblast metabolism, in striae distensae." 01/01/2000 - "Compared to placebo, treatment with a cream containing Centella asiatica extract, alpha tocopherol and collagen-elastin hydrolysates was associated with less women developing stretch marks (odds ratio 0.41, 95% confidence interval 0.17 to 0.99). "
5.	glycolic acid (glycolate)IBA 03/01/2012 - "A superficial texture analysis of 70% glycolic acid topical therapy and striae distensae." 08/01/1998 - "Analysis of these data reveals: 1) both regimens can improve the appearance of stretch marks; 2) these topical therapy regimens are safe and effective in study patients with minimal irritation; 3) elastin content within the reticular and papillary dermis can increase with topical 20% glycolic acid combined with 0.05% tretinoin emollient cream therapy; 4) both regimens increased epidermal thickness and decreased papillary dermal thickness in treated stretch marks when compared with untreated stretch marks; 5) combined epidermal and papillary dermal thickness in stretch marks treated with either topical regimen approaches that of normal skin; and 6) profilometry can objectively measure differences in skin texture associated with striae treatments when compared to controls, however, it is not sensitive enough to justify comparison or quantitative improvements between similarly effective treatments."
6.	atelocollagenIBA 04/01/2011 - "In conclusion, the ablative fractional resurfacing laser is effective in the treatment of striae distensae and succinylated atelocollagen may also be effective for striae distensae treatment. " 04/01/2011 - "The effect of succinylated atelocollagen and ablative fractional resurfacing laser on striae distensae." 04/01/2011 - "The ablative CO(2) fractional laser is effective in various cutaneous scars and this study was attempted to evaluate the effect of succinylated atelocollagen and ablative CO(2) fractional laser in the treatment of striae distensae. "
7.	Centella asiatica extractIBA 10/01/1993 - "Centella asiatica extract is used effectively in the treatment of keloids, leg ulcers, phlebitis, slow-healing wounds, leprosy, surgical lesions, striae distensae and cellulitis. " 01/01/2000 - "Compared to placebo, treatment with a cream containing Centella asiatica extract, alpha tocopherol and collagen-elastin hydrolysates was associated with less women developing stretch marks (odds ratio 0.41, 95% confidence interval 0.17 to 0.99). "
8.	GelsIBA 09/01/2013 - "A double-blind controlled clinical trial assessing the effect of topical gels on striae distensae (stretch marks): a non-invasive imaging, morphological and immunohistochemical study." 01/01/2001 - "Fibroblasts derived from women presenting striae distensae lesions were included into collagen gels to study their mechanical behavior: capacity to contract free-floating lattices and to produce isometric force in tense lattices. " 01/01/2001 - "Striae distensae fibroblasts contract collagen gels slower than normal human fibroblasts but the final contraction is similar. "
9.	CollagenIBA 10/01/2010 - "Percutaneous collagen induction therapy as a novel therapeutic option for Striae distensae." 01/01/2010 - "Differential scanning calorimetry showed increased enthalpy of phase transition and decreased onset temperature for collagen denaturation in striae distensae samples compared with bulk bariatric skin samples, consistent with tissue matrix degradation in striae. " 07/01/2005 - "Contractile forces generated by striae distensae fibroblasts embedded in collagen lattices." 04/01/2011 - "Striae distensae are dermal atrophic scars with epidermal thinning and decreased collagen and elastic fiber. " 11/01/2010 - "Late-stage striae distensae is a type of scar characterized by a loss of collagen and elastic fibers in the dermis. "
10.	Carbon DioxideIBA 10/01/2013 - "To evaluate the efficacy and safety of combination therapy with fractionated microneedle radiofrequency (RF) and fractional carbon dioxide (CO2) laser in the treatment of striae distensae. " 11/01/2010 - "Treatment of striae distensae using an ablative 10,600-nm carbon dioxide fractional laser: a retrospective review of 27 participants." 04/01/2011 - "In the current article, a review of fractional ablative resurfacing is presented alongside the results from a multi-center clinical study employing the fractional carbon dioxide (CO2) laser (SmartXide DOT, DEKA) for the treatment of rhytides, photoaging, scars and striae distensae."

Therapies and Procedures

1.	Lasers (Laser) 04/01/2011 - "The ablative fractional resurfacing laser was effective in the clinical improvement of striae distensae. " 01/01/2002 - "The use of lasers alone or in combination with other therapeutic modalities can provide a safe and effective reduction in the appearance of both red and white striae distensae. " 11/01/2011 - "Although a variety of laser and light sources have been used for the treatment of striae distensae, to date no definite 'gold standard' treatment modality has been determined. " 04/01/2005 - "The purpose of this study was to analyze the histologic and ultrastuctural changes seen after UVB laser- or light source-induced repigmentation of striae distensae. " 06/01/2003 - "The aim of our study was to follow-up 15 patients with stretch marks treated positively with the CuBr laser (577-511 nm) in 1998-99 and followed-up for 2 years. "
2.	Dye Lasers 06/01/2014 - "Efficacy of pulsed dye laser versus intense pulsed light in the treatment of striae distensae." 06/01/2014 - "Pulsed dye laser (PDL) and intense pulsed light (IPL) have been used to treat striae distensae. " 01/01/2007 - "Thirty-seven patients with abdominal striae distensae were treated with the Thermage and 585-nm pulsed dye laser in the first session at baseline. " 01/01/2007 - "Radiofrequency and 585-nm pulsed dye laser treatment of striae distensae: a report of 37 Asian patients." 04/01/1996 - "Treatment of stretch marks with the 585-nm flashlamp-pumped pulsed dye laser."
3.	Gas Lasers 06/01/2014 - "Clinical improvement of striae distensae in Korean patients using a combination of fractionated microneedle radiofrequency and fractional carbon dioxide laser." 10/01/2013 - "Combination therapy of fractionated microneedle RF and fractional CO2 laser is a safe treatment protocol with a positive therapeutic effect on striae distensae." 10/01/2013 - "Clinical improvement of striae distensae in Korean patients using a combination of fractionated microneedle radiofrequency and fractional carbon dioxide laser." 05/01/1999 - "Comparison of the 585 nm pulse dye laser and the short pulsed CO2 laser in the treatment of striae distensae in skin types IV and VI." 05/01/1999 - "As yet, no study has reported on the effects of either of these lasers in the treatment of stretch marks on persons with skin types 4 to 6. To assess the efficacy of short pulsed CO2 laser and pulsed dye laser for the treatment of stretch marks in skin types 4, 5, and 6. Four patients were initially enrolled in the study. "
4.	Solid-State Lasers 09/01/2014 - "We suggest that variable square pulse Er: YAG and long pulse Nd: YAG lasers are not useful in the treatment of striae distensae alba." 09/01/2014 - "We compared the efficacy of 1064 nm long pulse (LP) Nd: YAG laser and 2940 nm variable square pulse (VSP) erbium: YAG laser in the treatment of striae distensae. " 05/01/2008 - "Stretch marks: treatment using the 1,064-nm Nd:YAG laser."
5.	Optical Devices 04/01/2009 - "Review of the recent literature regarding clinical treatment of stretch marks with emphasis on the safety and efficacy of the newer optical devices and laser applications. "