Ischemic Postconditioning

The application of repeated, brief periods of vascular occlusion at the onset of REPERFUSION to reduce REPERFUSION INJURY that follows a prolonged ischemic event. The techniques are similar to ISCHEMIC PRECONDITIONING but the time of application is after the ischemic event instead of before.

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Networked: 737 relevant articles (92 outcomes, 146 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Zhao, Heng: 17 articles (06/2021 - 09/2006)
2.	Ji, Xunming: 14 articles (07/2021 - 06/2011)
3.	Heusch, Gerd: 13 articles (01/2021 - 12/2007)
4.	Ovize, Michel: 12 articles (04/2015 - 09/2007)
5.	Badalzadeh, Reza: 11 articles (06/2022 - 06/2012)
6.	Liu, Xiuheng: 10 articles (01/2019 - 08/2007)
7.	Downey, James M: 10 articles (11/2017 - 05/2006)
8.	Chen, Hui: 10 articles (08/2015 - 08/2007)
9.	Yellon, Derek M: 9 articles (12/2022 - 08/2004)
10.	Xia, Zhong-Yuan: 9 articles (01/2021 - 06/2009)

Related Diseases

1.	Reperfusion Injury 09/01/2012 - "Ischemic postconditioning was defined as rapid intermittent interruptions of blood flow in the early phase of reperfusion, which has been found to be protective against renal ischemia-reperfusion injury (IRI) in animal models but not in clinical trials.We" 09/01/2014 - "In the present study, we tested the hypothesis that ischemic postconditioning is effective for salvaging ischemic skeletal muscle resulting from limb ischemia-reperfusion injury, and that the mechanism involves expression of HIF-1α. " 01/01/2020 - "The protective effects of ischemic postconditioning on renal ischemia/reperfusion injury in mice and the role of miR-126 and Nrf2 signaling pathway in the process were the focus of this study. " 05/01/2011 - "The purpose of this study was to investigate the protective effects of ischemic post-conditioning on damage to the barrier function of the small intestine caused by limb ischemia-reperfusion injury. " 12/01/2009 - "This study aimed to contrast the protective effects of ischemic preconditioning and ischemic postconditioning in hepatic ischemia-reperfusion injury in rats. "
2.	Ischemia 12/01/2015 - "The neurological outcomes of the remote ischemic preconditioning (4.2 ± 0.4) and ischemic postconditioning (4.6 ± 0.8) groups were significantly improved when compared with the ischemia group (2.2 ± 04). " 03/27/2012 - "It can be concluded that ischemic postconditioning possesses strong protective effects against ischemia reperfusion-induced myocardium oxidative injury in IR rats." 01/01/2012 - "In this study, we try to find the better protocol of limb ischemia postconditioning by observing different protective effects of limb ischemic postconditioning (different strength and time windows in rabbits). " 02/01/2010 - "Ischemic postconditioning with three 10-second cycles of reperfusion/reocclusion was demonstrated effective for preserving +(dP/dt)max in isolated rat hearts that underwent 20 minutes of ischemia following 20 minutes of reperfusion." 01/01/2009 - "The ischemic postconditioning by three cycles of reperfusion/ischemia of 10/10s demonstrated to be effective for preservation of the myocardial contractility in isolated rat hearts which had undergone 20 min of ischemia."
3.	Infarction (Infarctions) 02/01/2011 - "Limb ischemic postconditioning significantly reduced infarct volume at 48 hours and improved functional outcomes at 4 weeks after HI. " 02/26/2008 - "Our objective was to determine whether ischemic postconditioning could afford (1) a persistent infarct size limitation and (2) an improved recovery of myocardial contractile function several months after infarction. " 08/19/2016 - "Given that most studies on ischemic postconditioning and all studies on remote ischemic preconditioning in patients with AMI reported reduced infarct size, it would be premature to give up on cardioprotection. " 08/19/2016 - "Ischemic postconditioning reduces infarct size in most, but not all, studies in patients undergoing interventional reperfusion of AMI, but may require direct stenting and exclusion of patients with >6 hours of symptom onset to protect. " 11/01/2015 - "The results of the present study indicated that the combination of early and delayed ischemic postconditioning further reduced the infarct volume, stabilized cerebral blood disturbance and attenuated neuronal apoptosis, compared with either alone. "
4.	Myocardial Ischemia (Ischemic Heart Diseases) 02/01/2017 - "Protective effects of ischemic postconditioning in myocardial ischemia/reperfusion (I/R) injury have been ever demonstrated, but the exact mechanisms remain unclear. " 03/01/2017 - "Ischemic post-conditioning (PostC) has been demonstrated as a novel strategy to harness nature's protection against myocardial ischemia-reperfusion (I/R). " 10/01/2010 - "Recent studies have shown that ischemic postconditioning reduces myocardial ischemia-reperfusion (I/R) injury; however, the effects of inhibiting apoptosis on cardioprotection induced by ischemic postconditioning remain to be determined. " 11/01/2022 - "Ischemic preconditioning (IPC), and ischemic postconditioning (IPost) have a significant protective effect on myocardial ischemia/reperfusion (MI/R) injury by alleviating oxidative stress and mitochondrial disturbances, although the underlying molecular mechanisms are unclear. " 06/18/2022 - "Ischemic postconditioning (IPostC) alleviates myocardial ischemia/reperfusion (IR) injury, but the protective effect is lost during diabetes. "
5.	Stroke (Strokes) 12/24/2011 - "The Protective Effects of Ischemic Postconditioning against Stroke: From Rapid to Delayed and Remote Postconditioning." 01/01/2018 - "Ischemic postconditioning (IPostC) protects against stroke, but few have studied the pathophysiological mechanisms of its long-term protective effects. " 01/01/2018 - "The mTOR cell signaling pathway is crucial to the long-term protective effects of ischemic postconditioning against stroke." 02/01/2013 - "Ischemic postconditioning has been established for its protective effects against stroke in animal models. " 12/24/2011 - "The author reviews the protective effects of ischemic postconditioning, a recently emerging strategy with broad implications in the search for new treatments in stroke and myocardial ischemic injury. "

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