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Post-Exercise Hypotension

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Transient reduction in blood pressure levels immediately after exercises that lasts 2-12 hours. The reduction varies but is typically 5-20 mm Hg when compared to pre-exercise levels. It exists both in normotensive and hypertensive individuals and may play a role in excercise related PHYSIOLOGIC ADAPTATION.

Also Known As:

Post Exercise Hypotension; Postexercise Hypotension; Hypotension, Post Exercise; Hypotension, Post-Exercise; Hypotension, Postexercise; Hypotensions, Post Exercise; Hypotensions, Post-Exercise; Hypotensions, Postexercise; Post Exercise Hypotensions; Post-Exercise Hypotensions; Postexercise Hypotensions

Networked: 41 relevant articles (0 outcomes, 11 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Hypertension (High Blood Pressure)
2.	Overweight

Experts

1.	Halliwill, John R: 3 articles (01/2006 - 07/2003)
2.	Pardono, Emerson: 2 articles (12/2013 - 01/2013)
3.	Tinucci, Tais: 2 articles (10/2008 - 08/2006)
4.	Bacurau, Reury F P: 2 articles (02/2008 - 05/2007)
5.	Moraes, Milton R: 2 articles (02/2008 - 05/2007)
6.	Casarini, Dulce E: 2 articles (02/2008 - 05/2007)
7.	Pesquero, Jorge L: 2 articles (02/2008 - 05/2007)
8.	Pesquero, João B: 2 articles (02/2008 - 05/2007)
9.	Maresh, Carl M: 2 articles (09/2007 - 01/2007)
10.	Pescatello, Linda S: 2 articles (09/2007 - 01/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Post-Exercise Hypotension:

1.	Carbon MonoxideIBA 03/01/2015 - "The acute postexercise hypotension response was mediated by a decrease in CO and SV, which was not compensated by an augmentation of SVR, as observed in the control arm of the study." 09/01/2006 - "Low- and high-intensity resistance exercises cause systolic post-exercise hypotension; however, only low-intensity exercise decreases diastolic BP. BP fall is due to CO decrease that is not compensated by SVR increase. " 01/01/2006 - "Future work should examine post-exercise hypotension effects in relation to exercise training in hypertensive populations and both acute and longitudinal training studies should be conducted that incorporate independent risk factors of hypertension as co-variables into their analysis on blood pressure effects."
2.	Naloxone (Narcan)FDA LinkGeneric 10/01/1992 - "In related studies of spontaneously hypertensive rats, this postexercise hypotension has been prevented with naloxone. " 11/01/1992 - "Naloxone did not prevent postexercise hypotension but transformed these inverse correlations into positive relationships. " 10/01/1992 - "Since naloxone reverses postexercise hypotension, opioid sensitive receptors appear to be involved in the reduction in systolic blood pressure following a single bout of submaximal exercise in normotensive humans." 10/01/1992 - "The purpose of the present investigation was to examined whether the postexercise hypotension may be reversed by antagonism of opioid sensitive receptors with naloxone in normotensive humans. "
3.	Kallikreins (Kallikrein)IBA 05/01/2007 - "Thus, the purpose of this study was to investigate the involvement of the vasodilators bradykinin and des-Arg(9)-BK and kallikrein activity in post-exercise hypotension promoted by 35 min of cycle ergometer (CE) or circuit weight-training (CWT) bouts in normotensive and hypertensive individuals. " 01/01/2013 - "Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition."
4.	BradykininIBA 05/01/2007 - "Thus, the purpose of this study was to investigate the involvement of the vasodilators bradykinin and des-Arg(9)-BK and kallikrein activity in post-exercise hypotension promoted by 35 min of cycle ergometer (CE) or circuit weight-training (CWT) bouts in normotensive and hypertensive individuals. " 01/01/2013 - "Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition."
5.	Plasma KallikreinIBA 11/01/2010 - "The present study was undertaken to determine the effects of type 2 diabetes (T2D) on plasma kallikrein activity (PKA) and postexercise hypotension (PEH). " 11/01/2010 - "Effect of type 2 diabetes on plasma kallikrein activity after physical exercise and its relationship to post-exercise hypotension."
6.	Vasodilator Agents (Vasodilators)IBA 05/01/2007 - "Thus, the purpose of this study was to investigate the involvement of the vasodilators bradykinin and des-Arg(9)-BK and kallikrein activity in post-exercise hypotension promoted by 35 min of cycle ergometer (CE) or circuit weight-training (CWT) bouts in normotensive and hypertensive individuals. "
7.	ProstaglandinsIBA 02/01/2005 - "The purpose of this study was to determine the potential contribution of a prostaglandin-dependent vasodilation to changes in systemic vascular conductance underlying postexercise hypotension; this was done by inhibiting production of prostaglandins with the cyclooxygenase inhibitor ibuprofen. "
8.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 02/01/2005 - "The purpose of this study was to determine the potential contribution of a prostaglandin-dependent vasodilation to changes in systemic vascular conductance underlying postexercise hypotension; this was done by inhibiting production of prostaglandins with the cyclooxygenase inhibitor ibuprofen. "
9.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/01/2013 - "This study investigated the chronic effect of blood pressure (BP) and post-exercise hypotension (PEH) during resistance training (RT) and its relation with the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in hypertensive elderly women. "
10.	Ibuprofen (Motrin)FDA LinkGeneric 02/01/2005 - "The purpose of this study was to determine the potential contribution of a prostaglandin-dependent vasodilation to changes in systemic vascular conductance underlying postexercise hypotension; this was done by inhibiting production of prostaglandins with the cyclooxygenase inhibitor ibuprofen. "

Therapies and Procedures

1.	Resistance Training 12/01/2013 - "The purpose of this study was to investigate postexercise hypotension (PEH) during a 4-month period of resistance training in hypertensive elderly women. " 02/01/2008 - "Previous studies demonstrated a reduction in blood pressure level immediately after different types of exercises, like running, cycling and resistance training, a phenomenon called post-exercise hypotension (PEH). " 10/01/2015 - "Influence of Load Intensity on Postexercise Hypotension and Heart Rate Variability after a Strength Training Session." 12/01/2014 - "Therefore, resistance training with FM, MM, and SM can induce increases in SBP after exercise, whereas after 60-min recovery, can induce decreases in SBP or post-exercise hypotension. " 01/01/2015 - "Effects of exercise intensity on postexercise hypotension after resistance training session in overweight hypertensive patients."
2.	Lower Body Negative Pressure 04/01/2008 - "We tested the hypothesis that following an acute bout of exercise cardiovascular and cerebrovascular responses to lower-body negative pressure (LBNP) would be altered due to post-exercise hypotension (PEH). " 06/01/2003 - "The hypothesis that reduced cardiac filling, as a result of lower body negative pressure (LBNP) and postexercise hypotension (PEH), would attenuate the reflex changes to heart rate (HR), skin blood flow (SkBF), and mean arterial pressure (MAP) normally induced by facial immersion was tested. "
3.	Catheters 02/01/1988 - "To determine whether post-exercise hypotension would occur in spontaneously hypertensive rats and to test the hypothesis that any reductions would result because of decreases in regional vascular resistances, hypertensive rats (n = 19) were instrumented with indwelling arterial catheters and Doppler probes to measure regional blood flows from the iliac, superior mesenteric, and renal arteries. "
4.	Fluid Therapy (Oral Rehydration Therapy) 06/01/2000 - "When phenylephrine was infused during recovery, there was no gain in intravascular albumin associated with a sustained decrease in PV (-7% or -280 mL, P < 0.05) observed at the end of experiment 2. These data suggest that post-exercise hypotension may be the mechanism for a gain of intravascular albumin via the lymph return, which enhances plasma water retention and PV restoration during recovery from exercise induced hypovolaemia, even without rehydration."
5.	Activities of Daily Living (ADL) 08/01/2001 - "We conclude that post exercise hypotension persists during mild exercise and simulated ADL. " 08/01/2001 - "Our purpose was to examine whether the transient suppression of blood pressure that occurs during the hours following acute exercise (termed post exercise hypotension) persists throughout an active period of subsequent mild exercise and simulated activities of daily living (ADL) using direct measurements of arterial pressure. " 08/01/2001 - "Post exercise hypotension is sustained during subsequent bouts of mild exercise and simulated activities of daily living."