Vascular System Injuries

Injuries to blood vessels caused by laceration, contusion, puncture, or crush and other types of injuries. Symptoms vary by site and mode of injuries and may include bleeding, bruising, swelling, pain, and numbness. It does not include injuries secondary to pathologic function or diseases such as ATHEROSCLEROSIS.

Also Known As:

Networked: 4292 relevant articles (154 outcomes, 362 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hyperplasia
2.	Hemorrhage
3.	Neointima
4.	Thrombosis (Thrombus)
5.	Inflammation

Experts

1.	Touyz, Rhian M: 15 articles (09/2015 - 05/2003)
2.	Horiuchi, Masatsugu: 14 articles (01/2016 - 01/2002)
3.	Rasmussen, Todd E: 14 articles (02/2015 - 04/2005)
4.	Weber, Christian: 13 articles (06/2014 - 11/2003)
5.	Jiang, Hong: 11 articles (09/2013 - 11/2002)
6.	Iwai, Masaru: 11 articles (07/2012 - 01/2002)
7.	Robson, Simon C: 10 articles (03/2014 - 05/2004)
8.	Sata, Masataka: 10 articles (12/2013 - 08/2002)
9.	Brass, Lawrence F: 9 articles (03/2015 - 11/2002)
10.	Ruggeri, Zaverio M: 9 articles (01/2015 - 03/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vascular System Injuries:

1.	Carbon MonoxideIBA 10/03/2005 - "These results indicate that the acute, local delivery of CO blocks the pathophysiological remodeling response to vascular injury, and identifies CO as a potentially important therapeutic agent in the treatment of vasculoproliferative disease." 05/01/1984 - "Successful therapy involves close co-operation between vascular and orthopaedic surgeons with the vascular injury taking priority. " 01/01/2007 - "CO protection against vascular injury may involve both anti-inflammatory and antiproliferative effects. " 01/01/2015 - "Our findings suggest a new mechanism by which HA can deteriorate Aβ-induced cytotoxicity through modulation of ER stress, which may provide significant insights into the pathogenesis of AD co-occurring with vascular injury. " 09/01/2009 - "The platelet surface is a dynamic interface that changes rapidly in response to stimuli to co-ordinate the formation of thrombi at sites of vascular injury. "
2.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 06/01/1997 - "In this study, we examined whether Sulodexide was effective in the inhibition of neointimal proliferation after vascular injury. " 06/01/2007 - "During the study period, 192 major vascular injuries were treated in the local population in the following distribution: extremity 70% (n=134), neck and great vessel 17% (n=33), and thoracoabdominal 13% (n=25). " 12/01/2015 - "A rabbit model of carotid vessel occlusion was used to test the hypothesis that SA-NT treatment coupled with TEB provides high recanalization rates while reducing vascular injury. " 11/01/2015 - "The hemostatic response requires the tightly regulated interaction of the coagulation system, platelets, other blood cells and components of the vessel wall at a site of vascular injury. " 10/01/2015 - "Blood clot formation is important to prevent blood loss in case of a vascular injury but disastrous when it occludes the vessel. "
3.	Estrogens (Estrogen)FDA Link 10/16/2012 - "Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury." 10/16/2012 - "The importance of these findings is underscored by in vivo experiments demonstrating loss of estrogen-mediated protection against vascular injury in the disrupting peptide mouse after carotid artery wire injury. " 08/01/2013 - "Many studies have shown that estrogen inhibits VSMC proliferation in response to vascular injury in the mouse carotid injury model. " 11/01/2008 - "Also, experimental studies have demonstrated beneficial effects of estrogen in improving vascular function and reducing vascular injury. " 06/04/2002 - "This study has characterized the expression of SRC-3 in cardiovascular tissue and the role of SRC-3 in estrogen-dependent vasoprotection from vascular injury. "
4.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/01/2013 - "Increased VEGF level in patients who showed no improvement with CSF drainage suggests that a possible greater ischemic or vascular injury may play a role in these patients. " 01/01/2015 - "Upregulation of vascular endothelial growth factor (VEGF) expression can inhibit intimal thickening after vascular injury. " 11/01/2014 - "These effects are partly driven by VEGF and CRP, suggesting an unfavorable balance between the pro healing (VEGF) and pro injury (CRP) factors that may promote vascular injury in OSA with and without metabolic syndrome." 01/01/2013 - "The increase in blood vascular endothelial growth factor (VEGF) levels after vascular injury was higher in young than in old mice. " 01/01/2011 - "The critical window during which PlGF-1 exerts its effect on VEGF-induced permeability highlights the importance of the translational significance of this work in that PLGF-1 likely serves as an endogenous anti-permeability factor whose effectiveness is limited to a precise time point following vascular injury. "
5.	Retinaldehyde (Retinal)IBA 03/01/2015 - "Here, we test whether PEDF ameliorates retinal vascular injury induced by HETEs and the underlying mechanisms. " 04/01/2013 - "Circulating mononuclear progenitor cells: differential roles for subpopulations in repair of retinal vascular injury." 01/01/2013 - "Targeting NOX2 in bone marrow and/or retinal cells may represent a novel therapeutic strategy for the treatment/prevention of vascular injury in the diabetic retina." 01/01/2013 - "NOX2-generated ROS produced by both bone marrow-derived cells and resident retinal cells contribute importantly to retinal vascular injury in the diabetic retina. " 01/01/2013 - "Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury."
6.	Insulin (Novolin)FDA Link 11/01/2014 - "We examined whether glycaemic control and vascular injury were improved by replacement of short-acting insulin with glulisine. " 10/01/2005 - "As arterial thrombosis accounts for the vast majority of cardiovascular complications in obese, insulin resistant patients, we hypothesized that improving insulin sensitivity may be effective in reducing the thrombotic response following vascular injury. " 12/01/2005 - "Obesity is a key component in development of the metabolic syndrome and it is becoming increasingly clear that a central factor in this is the production by adipose cells of bioactive substances that directly influence insulin sensitivity and vascular injury. " 04/01/2002 - "The correlation of individual BP with both PMN [Ca2+]i and plasma insulin levels, together with the fact that elevated [Ca2+]i mediates PMN priming, suggest that elevated [Ca2+]i and insulin are involved in the pathogenesis of hypertension-induced vascular injury in EH." 02/15/1994 - "The relation between insulin levels and restenosis after excimer laser angioplasty may provide insights into the biology of vascular injury and repair after coronary intervention."
7.	ThrombinFDA Link 01/01/1996 - "A therapy which enables safe and effective control of thrombin-induced responses following vascular injury may yet prove effective at reducing restenosis following percutaneous coronary revascularization." 10/01/2011 - "Our studies suggest that: (i) STIM1/SOCE is critical for the procoagulant activity but not the proadhesive function of platelets; and (ii) at the site of vascular injury, STIM1 and CalDAG-GEFI are critical for the first wave of thrombin generation mediated by procoagulant platelets." 09/01/1999 - "The study evaluated the role of thrombin in activation of vascular smooth muscle cells early after vascular injury. " 05/01/1994 - "By demonstrating a strong relationship between thrombin generation following de-endothelialisation and the progressive intimal proliferation, this study supports the hypothesis that thrombin is an important contributor to restenosis after vascular injury. " 01/01/2015 - "Utilizing a mouse endothelial injury model we show that thrombin cleavage of platelet PAR4 promotes leukocyte recruitment to sites of vascular injury. "
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/01/1992 - "However, anti-TNF-alpha provided no protection against dermal vascular injury and failed to reduce MPO content. " 07/01/2006 - "A better understanding of the immunological mechanisms responsible for the vascular injury has led to trials of anti-TNF-alpha agents with encouraging results. " 11/15/1995 - "These studies indicate that NIF prevents neutrophil-dependent lung vascular injury by inhibiting neutrophil adhesion to the TNF-alpha-activated endothelium." 11/01/2008 - "The absence of TNF-alpha and IFN-gamma in bone marrow cells synergistically inhibits neointimal formation following vascular injury, and thus, may provide new insights into the mechanisms underlying restenosis after PCI." 11/01/2008 - "Control (BALB/c), TNF-alpha-deficient (Tnf(-/-)), IFN-gamma-deficient (Ifng(-/-)), or double-deficient (Tnf(-/-)Ifng(-/-)) mice were subjected to wire-mediated vascular injury of the right femoral artery. "
9.	AntibodiesIBA 09/01/2003 - "Vascular injury occurs early in the course of disease, and previous in vitro studies suggest a primary role for anti-endothelial cell antibodies (AECAs) in mediating endothelial cell apoptosis. " 06/01/2013 - "Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury." 04/01/2013 - "Collectively, these data identify anti-LG3 antibodies as novel accelerators of immune-mediated vascular injury and obliterative remodeling." 04/01/2013 - "Antiperlecan antibodies are novel accelerators of immune-mediated vascular injury." 06/01/2007 - "Possible mechanisms include vascular injury and pathogenic antibodies. "
10.	CollagenIBA 10/01/2015 - "Cell-Substrate Interactions: Tuning of Collagen Scaffold Properties Modulates Embedded Endothelial Cell Regulatory Phenotype in Repair of Vascular Injuries In Vivo (Adv. " 10/01/2015 - "Tuning of Collagen Scaffold Properties Modulates Embedded Endothelial Cell Regulatory Phenotype in Repair of Vascular Injuries In Vivo." 09/01/2015 - "Immobilized at sites of vascular injury, VWF is activated by its interaction with collagen and the exertion of increased hemodynamic forces. " 06/25/2013 - "After vascular injury, platelets are rapidly activated by collagen and other agonists, causing them to adhere and aggregate to prevent blood loss. " 01/01/2013 - "Platelet dense granules are secreted upon vascular injury when platelets are exposed to for instance collagen. "

Therapies and Procedures

1.	Transplants (Transplant) 04/01/2000 - "Morphological studies showed that transplant glomerulopathy was not associated with increased severity of chronic vascular injury characterized by arterial and arteriolar intimal thickening or hyalinosis. " 04/01/2015 - "This series demonstrates the effectiveness of kidney clamp, perfuse, resuscitate as an effective intra-operative technique to salvage grafts after vascular injury. " 06/01/2014 - "Interposition reverse autogenous saphenous vein graft was most common type of repair in all types of missed vascular injuries. " 04/01/2013 - "Transperitoneal approach was preferred in all cases and primary suturing, graft interposition and end-to-end anastomoses were the surgical methods used for the repair of vascular injury. " 04/01/2012 - "Vascular injuries, though rare, necessitate vein grafts due to loss of length. "
2.	Amputation 01/01/2009 - "Despite spontaneous resolution of the vascular insult, it is important to remember the association of such fractures with vascular injuries in order to diagnose them early and prevent serious complications including amputation." 12/01/2015 - "Only 38% of patients with extremity vascular injury or amputation received a C intervention, with a significant reduction in blood products and intravenous fluids associated with receiving a C PHI (both p < 0.05). " 10/01/1990 - "Progress in the management of complex vascular injuries of the limbs has not eliminated the necessity for amputations. " 05/01/1986 - "Progress in the management of complex vascular injuries of the extremities has not eliminated the necessity for amputation. " 01/01/2015 - "This study will provide key information about the current process of care for Active Duty Service members and Veterans with polytrauma/vascular injuries at risk for persistent morbidity and late amputation. "
3.	Angioplasty (Angioplasty, Transluminal) 01/01/1993 - "Experimental animal studies have showed benefit from converting-enzyme inhibition in preventing myointimal proliferation after vascular injury in some species, but no such effect has been shown in clinical studies of restenosis following coronary angioplasty. " 01/01/2015 - "Neointimal proliferation after vascular injury is a key mechanism of restenosis, a major cause of percutaneous transluminal angioplasty failure and artery bypass occlusion. " 06/01/2013 - "A rabbit model of arterial angioplasty with local delivery of RvD2 (10 nM vs. vehicle control) was employed to examine effects on vascular injury in vivo. " 01/01/2013 - "Vascular smooth muscle cells (VSMCs) undergo phenotypic changes in response to vascular injury such as angioplasty. " 01/01/2013 - "The present data indicate that CTRP9 functions to attenuate neointimal formation following vascular injury through its ability to inhibit VSMC growth via cAMP-dependent mechanism, suggesting that the therapeutic approaches to enhance CTRP9 production could be valuable for prevention of vascular restenosis after angioplasty."
4.	Resuscitation 07/01/1980 - "Greater civilian use of firearms and improved transportation and resuscitation of the injured have provided our institutions with an increasing experience with subclavian vascular injuries. " 02/01/2013 - "We hypothesize improved outcomes in patients with exsanguinating vascular injuries when an aggressive hemostatic resuscitation is used with an inverse ratio of fresh frozen plasma (FFP) to packed red blood cell (PRBC). " 02/01/2013 - "A total of 258 patients with vascular injuries required component therapy resuscitation (low, n = 78; high, n = 156; inverse, n = 24). " 02/01/2013 - "This is a 5-year retrospective analysis of vascular injuries requiring hemostatic resuscitation. " 02/01/2013 - "Optimal resuscitation ratios for civilian exsanguinating vascular injuries has not been determined. "
5.	Homologous Transplantation (Allograft) 11/01/2015 - "Immunohistochemical analyses of pre-implanatation kidney allograft biopsies from patients with subsequent DGF showed significantly greater Nox2 levels and vascular injury compared with patients without DGF. " 04/15/2003 - "These results suggest that early withdrawal of CsA is a safe option, which allows a significant reduction of chronic histologic damage, particularly vascular injury, of cadaveric kidney allografts." 09/27/2002 - "These data are critical for the proper interpretation of studies evaluating acute and chronic allograft rejection and for the design of rational strategies to ameliorate vascular injury concomitant to the rejection process." 08/01/2005 - "BM-derived recipient cells are recruited to areas of donor vascular injury with intercalation of recipient EC and SMC in the setting of ongoing alloimmune recognition of the allograft. " 04/01/2005 - "We investigated how mediators of oxidative stress may increase allograft susceptibility to vascular injury. "