Kashin-Beck Disease

Disabling osteochondrodysplasia with OSTEOSCLEROSIS, cone-shaped METAPHYSIS, and shortening of the DIAPHYSIS. It is endemic in parts of Siberia and northern China. Mineral deficiencies (e.g., selenium, iodine), fungal cereal contamination, and water contamination may be contributing factors in its etiology.

Also Known As:

Networked: 117 relevant articles (3 outcomes, 30 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Osteoarthritis
2.	Pain (Aches)
3.	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia)
4.	Fibrosis (Cirrhosis)
5.	Necrosis

Experts

1.	Guo, Xiong: 19 articles (08/2015 - 01/2006)
2.	Wang, Wei: 9 articles (09/2015 - 03/2011)
3.	Kang, Pengde: 9 articles (05/2014 - 08/2010)
4.	Pei, Fuxing: 9 articles (05/2014 - 10/2010)
5.	Cao, Junling: 7 articles (01/2015 - 02/2009)
6.	Caterson, Bruce: 7 articles (01/2015 - 01/2008)
7.	Shen, Bin: 7 articles (01/2015 - 09/2011)
8.	Li, Siyuan: 7 articles (07/2014 - 02/2009)
9.	Li, Jian: 6 articles (01/2015 - 09/2011)
10.	Yang, Jing: 6 articles (04/2014 - 08/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Kashin-Beck Disease:

1.	SeleniumIBA 07/01/2003 - "The results of this study do not rule out the possibility that selenium may help to prevent the occurrence of Kashin-Beck disease. " 11/01/2015 - "Previous studies have shown that the selenium (Se) deficiency is an important factor for the etiology of Kashin-Beck disease (KBD). " 02/01/2009 - "We searched eight electronic databases and seven journals (upto July 2007) to identify randomized controlled trials (RCTs) and prospective non-RCTs comparing selenium supplementations with placebo or no intervention for preventing Kashin-Beck disease (KBD). " 05/01/2007 - "The focus of this study is to determine the relationship between selenium (Se) concentrations in child hair and the distribution of Kashin-Beck disease (KBD) in Tibet. " 11/01/2015 - "The Research on The Incidence of Kashin-Beck Disease and The Selenium Level In Children of Xunyi County."
2.	IodineIBA 01/01/2001 - "The percentages of low urinary iodine concentration were significantly greater in the subjects with Kashin-Beck disease. " 01/01/2001 - "Kashin-Beck disease and iodine deficiency in Tibet." 10/15/1998 - "Kashin-Beck disease--expanding the spectrum of iodine-deficiency disorders." 10/15/1998 - " Mean urinary iodine concentration was lower in subjects with Kashin-Beck disease than in control subjects and hypothyroidism was more frequent. " 10/15/1998 - "The mean urinary iodine concentration was lower in subjects with Kashin-Beck disease than in control subjects (1.2 vs. 1.8 microg per deciliter [94 vs. 142 nmol per liter], P<0.001) and hypothyroidism was more frequent (23 percent vs. 4 percent, P=0.01). "
3.	meloxicam (Mobic)FDA LinkGeneric 07/01/2012 - "A randomized, single-blind comparison of the efficacy and tolerability of hyaluronate acid and meloxicam in adult patients with Kashin-Beck disease of the knee." 07/01/2012 - "The aim of this study was to prospectively evaluate the efficacy and tolerability of hyaluronic acid (HA) and meloxicam for the treatment of knee pain due to Kashin-Beck disease (KBD). " 09/01/2011 - "Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck disease (KBD) patients." 09/01/2011 - "The objective of this study was to compare the efficacy and tolerability of celecoxib, meloxicam and paracetamol in late Kashin-Beck disease. " 09/01/2011 - "Adults (n = 168) with Kashin-Beck disease were randomised in clusters to receive six week courses of celecoxib 200 mg once daily, meloxicam 7.5 mg once daily or paracetamol 300 mg three times daily. "
4.	Acetaminophen (Paracetamol)FDA LinkGeneric 09/01/2011 - "Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck disease (KBD) patients." 09/01/2011 - "The objective of this study was to compare the efficacy and tolerability of celecoxib, meloxicam and paracetamol in late Kashin-Beck disease. " 09/01/2011 - "Adults (n = 168) with Kashin-Beck disease were randomised in clusters to receive six week courses of celecoxib 200 mg once daily, meloxicam 7.5 mg once daily or paracetamol 300 mg three times daily. "
5.	celecoxib (Celebrex)FDA Link 09/01/2011 - "Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck disease (KBD) patients." 09/01/2011 - "The objective of this study was to compare the efficacy and tolerability of celecoxib, meloxicam and paracetamol in late Kashin-Beck disease. " 09/01/2011 - "Adults (n = 168) with Kashin-Beck disease were randomised in clusters to receive six week courses of celecoxib 200 mg once daily, meloxicam 7.5 mg once daily or paracetamol 300 mg three times daily. "
6.	T-2 Toxin (T 2 Toxin)IBA 12/01/2010 - "The purpose of this study was to observe early lesions of rat epiphyseal plates and metaphysis caused by T-2 toxin and T-2 toxin combined with a low nutrition diet to determine possible pathogenic factors of Kashin-Beck disease (KBD). " 05/01/2014 - "MRI evaluation of the effect of Kashin-Beck disease-affected feed and T-2 toxin on the rat knees." 01/01/2014 - "T-2 toxin, a mycotoxin produced by Fusarium species, has been shown to cause diverse toxic effects in animals and is also a possible pathogenic factor of Kashin-Beck disease (KBD). " 01/01/2014 - "The rats received standard commercial feed with or without T-2 toxin additive, low-protein feed with or without T-2 toxin additive, and Kashin-Beck disease (KBD)-affected feed. " 08/01/2013 - "An animal model of Kashin-Beck disease induced by a low-nutrition diet and exposure to T-2 toxin."
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/01/2012 - "The objective of this study is to investigate the relationship between single-nucleotide polymorphisms (SNPs) of the tumor necrosis factor-α (TNF-α) and Fas genes and Kashin-Beck disease (KBD) in Shaanxi province, Northwest in China. " 01/01/2009 - "To investigate the role of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the pathogenesis and progression of Kashin-Beck disease (KBD) and primary osteoarthritis (OA). " 01/01/2009 - "[Expression of interleukin-1beta and tumor necrosis factor-alpha in the synovium and synovial fluid of patients with Kashin-Beck disease and osteoarthritis]." 10/01/2010 - "To investigate the serum level of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α in rats which have been fed with Kashin-Beck disease (KBD) epidemic district food. " 07/01/2007 - "To investigate the association of serum levels of hyaluronic acid (HA), tumor necrosis factor-alpha (TNF-alpha), vascular endothelial growth factor (VEGF), NO, and Se with the clinical manifestations in adult patients with Kashin-Beck disease (KBD). "
8.	Selenoproteins (Selenoprotein)IBA 06/01/2010 - "Association study between polymorphisms in selenoprotein genes and susceptibility to Kashin-Beck disease." 02/01/2015 - "Role of selenoprotein S (SEPS1) -105G>A polymorphisms and PI3K/Akt signaling pathway in Kashin-Beck disease." 09/01/2000 - "Disturbance of selenoprotein expression or function is associated with deficiency syndromes (Keshan and Kashin-Beck disease), might contribute to tumorigenesis and atherosclerosis, is altered in several bacterial and viral infections, and leads to infertility in male rodents." 01/01/2013 - "Association study of polymorphisms in selenoprotein genes and Kashin-Beck disease and serum selenium/iodine concentration in a Tibetan population." 01/01/2013 - "To investigate the association of the selenoprotein genes GPX1 (rs1050450, rs1800668, and rs3811699), TrxR2 (rs5748469), and DIO2 (rs225014) with Kashin-Beck disease (KBD) in a Tibetan population and to investigate the association of these SNPs with the serum iodine/selenium concentration in the Tibetan population. "
9.	Hyaluronic Acid (Hyaluronan)IBA 01/01/2015 - "The long-term efficacy and tolerability of hyaluronic acid in adult patients with Kashin-Beck disease of the knee." 06/01/2014 - "To assess the efficacy and safety of intra-articular hyaluronic acid (IAHA) injection in knee joints of patients with Kashin-Beck disease (KBD). " 06/01/2014 - "Evaluation of the therapeutic effect of treatment with intra-articular hyaluronic acid in knees for Kashin-Beck disease: a meta-analysis." 01/01/2015 - "The aim of this study was to prospectively evaluate the long-term efficacy and tolerability of hyaluronic acid (HA) for the treatment of knee pain due to Kashin-Beck disease (KBD). " 07/01/2012 - "The aim of this study was to prospectively evaluate the efficacy and tolerability of hyaluronic acid (HA) and meloxicam for the treatment of knee pain due to Kashin-Beck disease (KBD). "
10.	Biological Markers (Surrogate Marker)IBA 04/01/2009 - "To investigate the pathologic status of adult patients with Kashin-Beck disease (KBD) in an endemic area of China through detection of 5 biochemical markers in their urine, and to study the correlations between these markers and KBD. " 01/01/2008 - "Detection of serum proteomic changes and discovery of serum biomarkers for Kashin-Beck disease using surface-enhanced laser desorption ionization mass spectrometry (SELDI-TOF MS)." 01/01/2008 - "The purpose of the current study was to investigate the changes of serum proteome and discover potential biomarkers for Kashin-Beck disease (KBD) using surface-enhanced laser desorption ionization mass spectrometry (SELDI-TOF MS). "

Therapies and Procedures

1.	Lasers (Laser) 01/01/2008 - "Detection of serum proteomic changes and discovery of serum biomarkers for Kashin-Beck disease using surface-enhanced laser desorption ionization mass spectrometry (SELDI-TOF MS)." 01/01/2008 - "The purpose of the current study was to investigate the changes of serum proteome and discover potential biomarkers for Kashin-Beck disease (KBD) using surface-enhanced laser desorption ionization mass spectrometry (SELDI-TOF MS). "
2.	Arthroplasty 04/01/2014 - "This study aimed to prospectively determine the functional outcomes of total knee arthroplasty (TKA) in adult patients with severe Kashin-Beck disease (KBD) of the knee. " 04/01/2014 - "Total knee arthroplasty in elderly patients with severe Kashin-Beck disease of the knee."
3.	Parenteral Nutrition 01/01/1990 - "Biogeochemical anomalies, parenteral nutrition, malabsorption syndromes as conditions for the development of hyposelenosis are characterized as well as their manifestations (white-muscular disease, myopathies, cardiomyopathies, Keshan disease, Kashin-Beck disease). "
4.	Osteotomy 01/01/1998 - "The results of 247 osteotomies at the knee were analysed in 195 patients with Kashin-Beck disease. " 01/01/1998 - "Osteotomy at the knee for advanced cases of Kashin-Beck disease."
5.	Arthrodesis 01/01/2014 - "Arthroscopic ankle arthrodesis for treating osteoarthritis in a patient with kashin-beck disease."