Eosinophilic Esophagitis

Chronic ESOPHAGITIS characterized by esophageal mucosal EOSINOPHILIA. It is diagnosed when an increase in EOSINOPHILS are present over the entire esophagus. The reflux symptoms fail to respond to PROTON PUMP INHIBITORS treatment, unlike in GASTROESOPHAGEAL REFLUX DISEASE. The symptoms are associated with IgE-mediated hypersensitivity to food or inhalant allergens.

Also Known As:

Chronic Esophagitis, Eosinophilic; Esophagitis, Eosinophilic; Chronic Esophagitides, Eosinophilic; Eosinophilic Chronic Esophagitides; Eosinophilic Chronic Esophagitis; Eosinophilic Esophagitides; Esophagitides, Eosinophilic; Esophagitides, Eosinophilic Chronic; Esophagitis, Eosinophilic Chronic

Networked: 1248 relevant articles (107 outcomes, 116 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Food Hypersensitivity (Food Allergy)
2.	Eosinophilia
3.	Asthma (Bronchial Asthma)
4.	Anaphylaxis (Anaphylactic Shock)
5.	Atopic Dermatitis (Atopic Eczema)

Experts

1.	Dellon, Evan S: 88 articles (11/2022 - 04/2010)
2.	Rothenberg, Marc E: 70 articles (01/2022 - 03/2002)
3.	Furuta, Glenn T: 46 articles (01/2022 - 01/2002)
4.	Hirano, Ikuo: 44 articles (11/2022 - 01/2011)
5.	Collins, Margaret H: 43 articles (06/2022 - 07/2004)
6.	Lucendo, Alfredo J: 42 articles (11/2022 - 04/2007)
7.	Aceves, Seema S: 42 articles (01/2022 - 09/2005)
8.	Straumann, Alex: 41 articles (01/2022 - 07/2002)
9.	Spergel, Jonathan M: 40 articles (01/2022 - 02/2002)
10.	Katzka, David A: 39 articles (07/2022 - 07/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Eosinophilic Esophagitis:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2019 - "Although swallowed topical corticosteroids (STCs) are effective in inducing remission of active eosinophilic esophagitis (EoE), there are few data on maintenance of long-term remission. " 01/01/2016 - "Although effective in the treatment of eosinophilic esophagitis (EoE) in children, limited data exist on long-term safety and efficacy of swallowed topical corticosteroids. " 05/01/2011 - "Topical corticosteroids are effective in inducing clinical and histologic remission in patients with eosinophilic esophagitis (EoE). " 06/01/2008 - "We report on a case of eosinophilic esophagitis effectively treated with systemic corticosteroids. " 10/01/2017 - "Swallowed topical corticosteroids (STCs) are efficacious in inducing and presumably maintaining remission in patients with active eosinophilic esophagitis (EoE). "
2.	Proton Pump InhibitorsIBA 09/26/2023 - "• Proton pump inhibitor (PPI) treatment is effective for achieving clinical response and histologic remission in some patients with eosinophilic esophagitis (EoE). " 11/01/2019 - "Proton pump inhibitors (PPIs) are an effective treatment for eosinophilic esophagitis (EoE); however, only 30% to 60% of patients respond. " 01/01/2018 - "Long-term Treatment With Proton Pump Inhibitors Is Effective in Children With Eosinophilic Esophagitis." 01/01/2018 - "A New Paradigm in the Treatment of Eosinophilic Esophagitis: Proton Pump Inhibitors Are Safe, Aim for "Deep Remission"." 01/01/2021 - "Updated diagnostic guidelines for eosinophilic esophagitis (EoE) have eliminated the requirement for a proton pump inhibitor (PPI) trial, but there are no models to identify patients with EoE based on these new criteria. "
3.	Budesonide (Pulmicort)FDA LinkGeneric 12/01/2022 - "Mounting high-quality RCTs have confirmed the efficacy of oral budesonide in the treatment of eosinophilic esophagitis and that the effects of this drug may not be so dose-dependent. " 08/01/2010 - "Oral viscous budesonide is effective in children with eosinophilic esophagitis in a randomized, placebo-controlled trial." 01/01/2019 - "A new prepared oral viscous budesonide (PVB) has been effective in inducing clinical and histological remission in pediatric eosinophilic esophagitis (EoE). " 09/01/2015 - "4) Eosinophilic esophagitis: topical budesonide and exclusion diets are reasonably effective in PPI non-responders. " 11/01/2010 - "Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis."
4.	SteroidsIBA 10/01/2023 - "Although swallowed topical steroids are effective in inducing histological remission in eosinophilic esophagitis (EoE), their efficacy is limited by treatment nonadherence. " 01/01/2020 - "Topical steroids are effective in eosinophilic esophagitis (EoE), but patients often show different tendencies to relapse. " 01/01/2017 - "Six-Food Elimination Diet and Topical Steroids are Effective for Eosinophilic Esophagitis: A Meta-Regression." 01/01/2016 - "Topical steroids are first-line treatment agents for eosinophilic esophagitis; however, some studies have demonstrated modest efficacy in inducing histologic remission. " 04/01/2021 - "A meta-analysis of efficacy of topical steroids in eosinophilic esophagitis: From the perspective of histologic, clinical, and endoscopic outcome."
5.	AllergensIBA 04/12/2022 - "The step-up empiric elimination diet, starting from one/two food groups of most local allergens remains the current gold standard for a dietary approach in eosinophilic esophagitis (EoE) patients. " 10/01/2022 - "Eosinophilic esophagitis (EoE) is an allergen-mediated disease and elimination diets have proven to be effective to obtain clinical and histological remission. " 05/01/2014 - "In this study, we analyzed the involvement of these pathways in pediatric patients with eosinophilic esophagitis (EoE) before and after dietary allergen elimination. " 11/14/2023 - "Exposure of the esophageal mucosa to food allergens can cause acute mucosal responses in patients with eosinophilic esophagitis (EoE), but the underlying local immune mechanisms driving these acute responses are not well understood. " 09/06/2023 - "Sensitization to food and airborne allergens is common in the majority of patients with eosinophilic esophagitis (EoE). "
6.	Amino Acids FDA Link 01/01/2016 - "Thus, while exclusive amino acid-based elemental diets are the most effective in inducing histological remission of eosinophilic esophagitis (90.8%), their severe drawbacks limit their implementation in clinical practice. " 01/01/2022 - "Effect of amino acid-based formula added to four-food elimination in adult eosinophilic esophagitis patients: A randomized clinical trial." 11/01/1995 - "Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula." 01/01/2022 - "Extensively hydrolyzed formula and amino-acid formula are valid alternatives and may be particularly helpful when eliminating multiple foods, with severe complex gastrointestinal food allergies, eosinophilic esophagitis, severe eczema, or symptoms while exclusively breastfeeding. " 11/01/2022 - "Histologically Remarkable Eosinophilic Esophagitis Responsive to Dupilumab in a Gastrostomy Tube-Dependent Pediatric Patient on Amino Acid Formula."
7.	dupilumabIBA 01/01/2020 - "Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis." 09/03/2023 - "Real-World Efficacy of Dupilumab in Severe, Treatment-Refractory, and Fibrostenotic Patients With Eosinophilic Esophagitis." 12/22/2022 - "Among patients with eosinophilic esophagitis, subcutaneous dupilumab administered weekly improved histologic outcomes and alleviated symptoms of the disease. " 01/01/2022 - "Improvement in eosinophilic esophagitis when using dupilumab for other indications or compassionate use." 01/01/2023 - "The enormous potential of biologics for the treatment of FA and EGIDs is highlighted by the significant increases in the number of ongoing clinical trials (more than 30) evaluating their use in these disease states, as well as by the recent US Food and Drug Administration approval of dupilumab for the treatment of eosinophilic esophagitis. "
8.	Fluticasone (Cutivate)FDA LinkGeneric 09/01/2015 - "Histological Response to Fluticasone Propionate in Patients With Eosinophilic Esophagitis Is Associated With Improved Functional Esophageal Mucosal Integrity." 11/01/2006 - "We aimed to determine the efficacy of swallowed fluticasone propionate (FP) in the treatment of eosinophilic esophagitis. " 05/01/2016 - "Prospective, comparative effectiveness trial of cow's milk elimination and swallowed fluticasone for pediatric eosinophilic esophagitis." 11/01/2006 - "A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis." 07/01/2012 - "Swallowed fluticasone improves histologic but not symptomatic response of adults with eosinophilic esophagitis."
9.	TabletsIBA 01/01/2021 - "Straumann A, Lucendo AJ, Miehlke S, et al. Budesonide orodispersible tablets maintain remission in a randomized, placebo-controlled trial of patients with eosinophilic esophagitis. " 11/01/2020 - "Budesonide Orodispersible Tablets Maintain Remission in a Randomized, Placebo-Controlled Trial of Patients With Eosinophilic Esophagitis." 01/01/2021 - "In eosinophilic esophagitis, budesonide orodispersible tablets maintained remission at 48 wk." 11/01/2022 - "Fluticasone Propionate Orally Disintegrating Tablet (APT-1011) for Eosinophilic Esophagitis: Randomized Controlled Trial." 12/01/2021 - "Economic Evaluation of Budesonide Orodispersible Tablets for the Treatment of Eosinophilic Esophagitis: A Cost-Utility Analysis."
10.	AntigensIBA 07/01/2021 - "Eosinophilic esophagitis (EoE) is a chronic, antigen-driven disorder for which endoscopic monitoring and multidisciplinary care are recommended to achieve histologic remission. " 01/01/2019 - "Eosinophilic esophagitis (EoE) is an immune-mediated disease triggered by food antigens for which dietary elimination treatment can induce and sustain histologic remission. " 03/15/2015 - "The present study aims to determine whether prolonged antigen exposure in vivo sensitizes TRPA1 in a guinea pig model of eosinophilic esophagitis (EoE). " 02/01/2002 - "The purpose of this study was to identify potential food antigens in eosinophilic esophagitis. " 03/14/2023 - "Eosinophilic esophagitis is a Th-2 antigen-mediated disease in which there is an influx of eosinophils to all layers of the esophagus, triggering an inflammatory response. "

Therapies and Procedures

1.	Therapeutics 12/01/2022 - "Furthermore, long-term, high-dose PPI therapy is a recommended option for managing eosinophilic esophagitis, resulting in histologic remission in approximately 40% of patients. " 01/01/2019 - "In this retrospective cohort study, we analyzed EoE patients in histologic remission (<15 eosinophil/high-power field) but who doubled the esophageal eosinophil count between seasons without change in eosinophilic esophagitis-specific therapy. " 06/01/2019 - "Pediatric eosinophilic esophagitis effectively treated with a short-term 6-food-group elimination diet and reintroduction therapy: A case report." 01/01/2020 - "Efficacy of Dairy Free Diet and 6-Food Elimination Diet as Initial Therapy for Pediatric Eosinophilic Esophagitis: A Retrospective Single-Center Study." 01/01/2021 - "To further assess the relationship between short-term histologic remission and maintenance therapy on need for repeat dilation in eosinophilic esophagitis. "
2.	Immunotherapy 01/01/2021 - "Complete remission of eosinophilic esophagitis with multi-aeroallergen subcutaneous immunotherapy: A case report." 10/01/2016 - "In a recent trial in patients suffered from eosinophilic esophagitis, after 2 years of the CRD-guided exclusion diet and specific immunotherapy, significant clinical improvement was observed, and 68% of patients were discharged (cure based on negative biopsy, no symptoms, and no medication intake). " 01/01/2020 - "Efficacy of Epicutaneous Immunotherapy in Children With Milk-Induced Eosinophilic Esophagitis." 09/26/2023 - "Oral immunotherapy (OIT) may induce eosinophilic esophagitis (EoE). " 08/10/2023 - "Ethical Implications of Continuing Oral Immunotherapy After the Development of Eosinophilic Esophagitis."
3.	Diet Therapy (Therapy, Diet) 10/05/2017 - "Improvement in Esophageal Distensibility in Response to Medical and Diet Therapy in Eosinophilic Esophagitis." 01/01/2023 - "Development of a Practical Guide to Implement and Monitor Diet Therapy for Eosinophilic Esophagitis." 01/01/2023 - "New approaches to diet therapy for eosinophilic esophagitis." 01/01/2021 - "Diet Therapy in Eosinophilic Esophagitis. " 01/01/2020 - "Approaches to diet therapy for eosinophilic esophagitis."
4.	Gluten-Free Diet 08/01/2012 - "To examine the clinical, endoscopic and histological features of children with both conditions to evaluate whether eosinophilic esophagitis responds to a gluten-free diet. " 08/01/2012 - "In patients with celiac disease, a gluten-free diet did not appear to induce remission of coexistent endoscopic and histological features of eosinophilic esophagitis." 08/01/2012 - "In six of these seven (86%) patients, no endoscopic or histological improvement of eosinophilic esophagitis was observed, while in one patient, histological remission of esophageal eosinophilia occurred while on a gluten-free diet. " 08/01/2012 - "Gluten-free diet does not appear to induce endoscopic remission of eosinophilic esophagitis in children with coexistent celiac disease." 08/01/2012 - "It is unknown whether eosinophilic esophagitis in patients with celiac disease responds to a gluten-free diet. "
5.	Gastrectomy 10/01/2019 - "Eosinophilic esophagitis after total gastrectomy treated with proton pump inhibitors: a case report." 02/01/2023 - "Among the most significant advances are the antiviral treatment for hepatitis D, the new Chicago classification version 4 for esophageal motility disorders, the first biological treatment for eosinophilic esophagitis, a randomized controlled trial about the efficacy of screening colonoscopy, novel endoscopic techniques such as G-POEM or endoscopic sleeve gastrectomy, and emerging IBD therapies such as ozanimod, upadacitinib or anti-IL23 antibodies. "