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Proteostasis Deficiencies

Disorders caused by imbalances in the PROTEIN HOMEOSTASIS network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins.
Also Known As:
Protein Folding Diseases; Protein Folding Disorders; Protein Misfolding Diseases; Proteostasis Dysfunctions; Deficiency, Proteostasis; Disease, Protein Folding; Disease, Protein Misfolding; Disorder, Protein Folding; Disorder, Protein Misfolding; Dysfunction, Proteostasis; Folding Disease, Protein; Folding Disorder, Protein; Misfolding Disease, Protein; Misfolding Disorder, Protein; Protein Folding Disease; Protein Folding Disorder; Protein Misfolding Disease; Protein Misfolding Disorder; Proteinopathies; Proteostasis Deficiency; Proteostasis Dysfunction; Protein Misfolding Disorders; Proteinopathy
Networked: 1400 relevant articles (37 outcomes, 99 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neurodegenerative Diseases (Neurodegenerative Disease)
2. Alzheimer Disease (Alzheimer's Disease)
3. Tauopathies
4. Parkinson Disease (Parkinson's Disease)
5. Prion Diseases (Transmissible Spongiform Encephalopathies)

Experts

1. Dobson, Christopher M: 16 articles (08/2020 - 08/2009)
2. Wang, Xuejun: 14 articles (01/2019 - 05/2009)
3. Kovacs, Gabor G: 13 articles (03/2022 - 07/2011)
4. Jellinger, Kurt A: 13 articles (01/2022 - 09/2003)
5. Trojanowski, John Q: 13 articles (01/2022 - 11/2011)
6. Giraldo, Rafael: 12 articles (01/2018 - 04/2008)
7. Kelly, Jeffery W: 11 articles (01/2022 - 12/2005)
8. Vendruscolo, Michele: 11 articles (01/2022 - 12/2011)
9. Knowles, Tuomas P J: 11 articles (01/2021 - 06/2011)
10. Giasson, Benoit I: 9 articles (03/2021 - 05/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Proteostasis Deficiencies:
1. Proteins (Proteins, Gene)FDA Link
2. Molecular Chaperones (Chaperone, Molecular)IBA
3. Biomarkers (Surrogate Marker)IBA
4. Proteasome Endopeptidase Complex (Proteasome)IBA
5. TrehaloseIBA
6. DisaccharidesIBA
7. Amyloid (Amyloid Fibrils)IBA
8. DNA-Binding Proteins (DNA Binding Protein)IBA
9. polyglutamineIBA
10. Protein AggregatesIBA

Therapies and Procedures

1. Therapeutics
2. Immunotherapy
3. Topical Administration
4. Precision Medicine
5. Lab-On-A-Chip Devices