Member 1 Group A Nuclear Receptor Subfamily 6

An orphan nuclear receptor expressed mainly in the GERM CELLS of GONADS. It functions as a transcription factor that binds to a direct repeat of the sequence AGGTCA and may play a role in the regulation of EMBRYOGENESIS and germ cell differentiation.

Also Known As:

Nuclear Receptor Subfamily 6, Group A, Member 1; Germ Cell Nuclear Factor; Neuronal Cell Nuclear Factor; Nuclear Receptor NR6A1; Retinoid Receptor Related Testis Specific Receptor; Retinoid Receptor-Related Testis-Associated Receptor; Retinoid Receptor Related Testis Associated Receptor

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Cytoplasmic and Nuclear Receptors: 3987
    - Orphan Nuclear Receptors: 423
      - Member 1 Group A Nuclear Receptor Subfamily 6: 6
        human NR6A1 protein
        mouse Nr6a1 protein
        rat Nr6a1 protein
        zebrafish nr6a1a protein
  - DNA-Binding Proteins: 2009
    - Orphan Nuclear Receptors: 423
      - Member 1 Group A Nuclear Receptor Subfamily 6: 6
        human NR6A1 protein
        mouse Nr6a1 protein
        rat Nr6a1 protein
        zebrafish nr6a1a protein

Experts

1.	Bai, Yang: 1 article (08/2022)
2.	Cai, Zhou: 1 article (08/2022)
3.	He, Xin: 1 article (08/2022)
4.	Liu, Shuai: 1 article (08/2022)
5.	Pan, Baihong: 1 article (08/2022)
6.	Wu, Kemin: 1 article (08/2022)
7.	Choi, Wonbin: 1 article (01/2018)
8.	Do, Hyun-Jin: 1 article (01/2018)
9.	Kim, Jae-Hwan: 1 article (01/2018)
10.	Kim, Jin-Hoi: 1 article (01/2018)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 06/01/2013 - "In the present study, we investigated the effects of two nuclear receptors, liver receptor homolog (LRH)-1 and germ cell nuclear factor receptor (GCNF) and epigenetic modifications on CR-1 gene expression in NTERA-2 human embryonal carcinoma cells and in breast cancer cells. "
2.	Carcinoma (Carcinomatosis) 01/01/2018 - "We demonstrate that OCT4 expression is regulated by germ cell nuclear factor (GCNF) via its interactions with three nuclear receptor (NR) binding sites within OCT4 promoter conserved regions (CRs) in human embryonic carcinoma (EC) NCCIT cells. " 04/01/2003 - "The germ cell nuclear factor (GCNF, NR6A1) is a nuclear orphan receptor that functions as a transcriptional repressor and is transiently expressed in mammalian carcinoma cells during retinoic acid (RA) induced neuronal differentiation. "
3.	Atherosclerosis 08/01/2022 - "Nuclear receptor subfamily 6 group A member 1 (NR6A1) is involved in promoting the apoptotic process of vascular smooth muscle cells (VSMCs) which is a critical process involved in atherosclerosis, but the action mechanism remains to be determined. "
4.	Neoplasms (Cancer) 07/01/2017 - "Two SAMRs, located at the CpG island shores of leucine zipper tumor suppressor 2 (LZTS2) and nuclear receptor subfamily 6 group a member 1 (NR6A1), respectively, were identified. "
5.	Dosage-sensitive sex reversal 01/01/2004 - "In particular, gene-silencing events elicited by chicken ovalbumin upstream promoter-transcription factors (COUP-TFs); dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX-1); germ cell nuclear factor (GCNF); short heterodimer partner (SHP); and testicular receptors 2 and 4 (TR2 and TR4) are among the best characterized. "

Related Drugs and Biologics

1.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
2.	COUP Transcription Factors
3.	Tretinoin (Retinoic Acid)