Descemet Stripping Endothelial Keratoplasty

A surgical procedure or KERATOPLASTY involving selective stripping and replacement of diseased host DESCEMET MEMBRANE and CORNEAL ENDOTHELIUM with a suitable and healthy donor posterior lamella. The advantage to this procedure is that the normal corneal surface of the recipient is retained, thereby avoiding corneal surface incisions and sutures.

Networked: 89 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Patel, Sanjay V: 7 articles (04/2022 - 10/2010)
2.	Baratz, Keith H: 5 articles (04/2022 - 10/2010)
3.	Seedor, John A: 5 articles (11/2019 - 02/2010)
4.	McLaren, Jay W: 5 articles (01/2016 - 10/2010)
5.	Maguire, Leo J: 4 articles (04/2022 - 10/2010)
6.	Chaurasia, Sunita: 4 articles (02/2022 - 11/2012)
7.	Hammersmith, Kristin M: 4 articles (08/2021 - 08/2013)
8.	Nagra, Parveen K: 4 articles (08/2021 - 08/2013)
9.	Rapuano, Christopher J: 4 articles (08/2021 - 08/2013)
10.	Kang, Joann J: 4 articles (11/2019 - 12/2016)

Related Diseases

1.	Fuchs' Endothelial Dystrophy 12/01/2011 - "To evaluate the quality of vision (visual acuity and straylight) in patients with Fuchs dystrophy and the improvement in visual quality after Descemet stripping endothelial keratoplasty (DSEK). " 05/12/2023 - "This study aimed to compare the long-term endothelial cell loss, graft survival, and clinical outcomes in patients with Fuchs endothelial dystrophy (FED) after Descemet stripping endothelial keratoplasty (DSEK) and Descemet membrane endothelial keratoplasty (DMEK) using a standardized surgical protocol. " 09/01/2022 - "The mechanism of DMET in PBK probably occurs because of migration of the donor endothelial cells from partially attached Descemet stripping endothelial keratoplasty grafts to the host stroma, in contrast to Fuch endothelial dystrophy, where the endothelial cells from the periphery migrate to the center. " 01/01/2019 - "The common indications for DMEK were pseudophakic bullous keratopathy -57.1%, Fuchs endothelial dystrophy-34.7%, failed grafts-6.1% (Descemet stripping endothelial keratoplasty (DSEK) and failed penetrating keratoplasty), and others. " 01/01/2017 - "In this retrospective case series, a series of 35 eyes in 34 consecutive patients who underwent Descemet stripping endothelial keratoplasty for Fuchs endothelial dystrophy or previously failed full-thickness grafts at a single tertiary care center from March 2013 to March 2014 was included. "
2.	Astigmatism 10/01/2008 - "Femtosecond laser-assisted Descemet stripping endothelial keratoplasty was effective in treating endothelial failure with minimal induced refractive astigmatism, limited improvement of BSCVA, and induction of a hyperopic shift. " 01/01/2015 - "We conducted a systematic review of the English-language literature published from January 1, 2013, to December 31, 2013, using the following PubMed search and Medical Subject Headings terms: cornea transplantation, keratoplasty, Descemet membrane endothelial keratoplasty, Descemet stripping endothelial keratoplasty, cross linking, pre-Descemet's layer, Rho-associated kinase, keratoprosthesis, infectious keratitis, corneal dystrophy, corneal astigmatism, and keratoconus. "
3.	Glaucoma 03/01/2014 - "The aim of this study was to determine the outcomes after Descemet stripping endothelial keratoplasty (DSEK) in eyes with previous glaucoma surgery. " 05/01/2023 - "Graft Survival, Graft Rejection, and Glaucoma in a Consecutive Series of Descemet Stripping Endothelial Keratoplasty." 11/01/2019 - "Clinical Outcomes of Descemet Stripping Endothelial Keratoplasty in Eyes With Glaucoma Drainage Devices." 11/01/2019 - "In Reply: Clinical Outcomes of Descemet Stripping Endothelial Keratoplasty in Eyes With Glaucoma Drainage Devices." 11/01/2019 - "To compare visual outcomes and complications of Descemet stripping endothelial keratoplasty (DSEK) in eyes with anterior chamber (AC) versus pars plana (PP) glaucoma drainage devices (GDDs). "
4.	Corneal Edema 07/01/2022 - "The purpose of this study was to report a novel technique of donor lenticule insertion in Descemet stripping endothelial keratoplasty (DSEK) in aphakic corneal edema with large iris defect and without any posterior capsular support. " 11/22/2023 - "Patients with chronic corneal edema underwent removal of the EK graft and implantation of an artificial endothelial replacement membrane (EndoArt, EyeYon Medical, Israel) several months after 2 or more Descemet stripping endothelial keratoplasty procedures. " 07/01/2023 - "The various etiologies of corneal edema included graft failure after Descemet stripping endothelial keratoplasty, a failed penetrating keratoplasty, and 3 cases of pseudophakic corneal edema. " 12/01/2016 - "Influence of Early Descemet Stripping Endothelial Keratoplasty on Visual Outcomes in Pseudophakic Corneal Edema." 02/01/2014 - "The aim was to report the surgical outcomes of simultaneous Descemet stripping endothelial keratoplasty (DSEK) with a retropupillary fixated iris claw lens in patients with aphakic corneal edema without capsular support. "
5.	Fibrosis (Cirrhosis) 02/01/2014 - "Recurrent progressive anterior segment fibrosis syndrome following a descemet-stripping endothelial keratoplasty in an infant with congenital aniridia." 01/01/2023 - "The purpose of this study was to investigate the effect of celastrol (CEL) on corneal stromal fibrosis after Descemet stripping endothelial keratoplasty (DSEK) and its associated mechanism. " 01/01/2023 - "Celastrol Alleviates Corneal Stromal Fibrosis by Inhibiting TGF-β1/Smad2/3-YAP/TAZ Signaling After Descemet Stripping Endothelial Keratoplasty."

Related Drugs and Biologics

1.	celastrol
2.	rho-Associated Kinases
3.	Steroids
4.	Retinaldehyde (Retinal)
5.	Cyanoacrylates
6.	BNT162 Vaccine
7.	prednisolone acetate

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Corneal Transplantation (Keratoplasty)
3.	Penetrating Keratoplasty
4.	Intraocular Lenses (Intraocular Lens)
5.	Phacoemulsification