Anetoderma

Benign DERMATOSIS caused by a loss of dermal ELASTIC TISSUE resulting in localized sac-like areas of flaccid skin. It can be either primary (idiopathic) or secondary to other skin conditions, PENICILLAMINE use, or premature birth.

Also Known As:

Networked: 58 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Syphilis
2.	Systemic Lupus Erythematosus (Libman-Sacks Disease)
3.	Anetoderma
4.	Pseudoxanthoma Elasticum (Gronblad Strandberg Syndrome)
5.	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)

Experts

1.	Hodak, Emmilia: 3 articles (02/2010 - 04/2007)
2.	David, Michael: 3 articles (02/2010 - 04/2007)
3.	Vabres, Pierre: 2 articles (05/2010 - 04/2002)
4.	Sheahan, K: 1 article (08/2015)
5.	O'Gorman, S M: 1 article (08/2015)
6.	Collins, P: 1 article (08/2015)
7.	Motegi, Sei-ichiro: 1 article (04/2015)
8.	Hirai, Nobuyuki: 1 article (04/2015)
9.	Okada, Etsuko: 1 article (04/2015)
10.	Ishikawa, Osamu: 1 article (04/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Anetoderma:

1.	AntibodiesIBA 01/01/1995 - "The finding of anetoderma in 5 patients followed up because of false-positive seroreactions of syphilis prompted us to study the occurrence of antiphospholipid (aPL) antibodies in anetoderma. " 01/01/2003 - "We discuss the possible role of these antibodies in the pathogenesis of anetoderma, and, when detected, the need to check for an associated anti-phospholipid syndrome in such patients." 01/01/2003 - "We describe the case of a 30-year-old woman with systemic lupus erythematosus-associated anetoderma and positive anti-phospholipid antibodies. " 01/01/2003 - "Systemic lupus erythematosus-associated anetoderma and anti-phospholipid antibodies." 06/01/1991 - "burgdorferi antibodies have been found in patients with localized sclerodermalike lesions (circumscribed scleroderma, lichen sclerosus et atrophicus, anetoderma), and frequent simultaneous occurrence of ACA suggests an association with late B. "
2.	Anticardiolipin AntibodiesIBA 06/01/1995 - "In this study, we wanted to determine whether there was an association in the development of anetoderma and elevated anticardiolipin antibodies (ACA) in HIV-1 patients. " 01/01/2014 - "Primary anetoderma associated with primary Sjögren syndrome and anticardiolipin antibodies." 06/01/1995 - "Anticardiolipin antibodies were moderately elevated in seven of eight patients with lesions and were borderline in the four HIV-1-positive patients without lesions of anetoderma. " 06/01/1995 - "Increased anticardiolipin antibodies associated with the development of anetoderma in HIV-1 disease. " 06/01/1995 - "In patients with autoimmune disease, anetoderma has been associated with increased levels of antiphospholipid antibodies (APL) that include anticardiolipin antibodies (ACA) and lupus anticoagulant (LA). "
3.	Antiphospholipid AntibodiesIBA 12/01/2012 - "Anetoderma secondary to antiphospholipid antibodies." 05/01/2011 - "Primary anetoderma: a cutaneous marker of antiphospholipid antibodies." 02/01/2010 - "However, there is growing evidence linking primary anetoderma with a wide range of immunologic abnormalities, the most common being the presence of antiphospholipid antibodies. " 02/01/2008 - "Primary anetoderma is a cutaneous sign of antiphospholipid antibodies." 04/01/2007 - "Primary anetoderma and antiphospholipid antibodies--review of the literature."
4.	CollagenIBA 11/01/2009 - "The obvious changes in collagen fibers and the occurrence of inflammatory cell infiltration in erythematous tissue suggested that the variations of these two components were also the main pathogenesis of anetoderma, except for the deficiency of elastic fibers. " 01/01/2007 - "Occasionally, elastic and collagen fibers in the lesions degenerate and result in a lax area of skin termed anetoderma. " 02/06/1964 - "[INFORMATION ON COLLAGEN CHANGES IN ANETODERMA OF THE SCHWENINGER-BUZZI TYPE]." 01/01/1992 - "The interference of penicillamine with collagen and elastin cross-linking can lead to wrinkling and anetoderma-like lesions in flexural areas as well as fragility and hemorrhagic blisters in pressure areas. "
5.	Metalloproteases (Metalloproteinases)IBA 04/01/2002 - "Anetoderma: an altered balance between metalloproteinases and tissue inhibitors of metalloproteinases." 09/01/2011 - "Upregulation of matrix metalloproteinases (MMPs) and downregulation of tissue inhibitors of metalloproteinases (TIMP) have been reported in cultured fibroblasts from patients with congenital cutis laxa (CL) or anetoderma. "
6.	Matrix MetalloproteinasesIBA 04/01/2015 - "Cutaneous marginal zone B-cell lymphoma evolving into anetoderma: a role of matrix metalloproteinases?" 09/01/2011 - "Upregulation of matrix metalloproteinases (MMPs) and downregulation of tissue inhibitors of metalloproteinases (TIMP) have been reported in cultured fibroblasts from patients with congenital cutis laxa (CL) or anetoderma. "
7.	Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA 08/01/1991 - "In addition, she was found to have autoimmune hemolysis and circulating lupus anticoagulant associated with recurrent deep-vein thrombosis and a history of Graves' disease (starting 5 years after onset of primary anetoderma). " 06/01/1995 - "In patients with autoimmune disease, anetoderma has been associated with increased levels of antiphospholipid antibodies (APL) that include anticardiolipin antibodies (ACA) and lupus anticoagulant (LA). "
8.	Penicillamine (Cuprimine)FDA Link 08/19/2004 - "Currently, anetoderma is classified as either primary (idiopathic), or secondary anetoderma (which is associated with a variety of skin conditions, penicillamine use, or neonatal prematurity). " 01/01/1992 - "The interference of penicillamine with collagen and elastin cross-linking can lead to wrinkling and anetoderma-like lesions in flexural areas as well as fragility and hemorrhagic blisters in pressure areas. "
9.	ElastinIBA 07/01/1984 - "These observations suggest that the deficiency of elastin in the dermis may lead to development of the cutaneous lesions of anetoderma." 07/01/1984 - "Anetoderma: biochemical and ultrastructural demonstration of an elastin defect in the skin of three patients." 01/01/1992 - "The interference of penicillamine with collagen and elastin cross-linking can lead to wrinkling and anetoderma-like lesions in flexural areas as well as fragility and hemorrhagic blisters in pressure areas. "
10.	Antinuclear AntibodiesIBA 08/01/1991 - "In a woman with clinical and histopathologic features of primary anetoderma (Jadassohn-Pellizzari type) of 30 years' duration, laboratory investigation disclosed positive antinuclear factor, hypocomplementemia, hypergammaglobulinemia, granular deposits of immunoreactants along the dermoepidermal junction, and fibrillar deposits in the papillary dermis. " 12/01/2012 - "We present a case of a patient with generalized anetoderma, who was later found to have positive antinuclear antibodies and antiphospholipid antibodies (APAs). "

Therapies and Procedures

1.	Neonatal Intensive Care 05/01/2010 - "Anetoderma of prematurity: an iatrogenic consequence of neonatal intensive care." 06/01/1996 - "Eight of the 9 infants were noted to have developed anetoderma on the trunk and proximal extremities while in the neonatal intensive care unit. " 06/01/1996 - "We report on 9 extremely premature infants who developed patches of anetoderma during their course in the neonatal intensive care unit. "
2.	Catheters 11/01/2011 - "Complications arising from procedures include thrombosis caused by placement of peripherally inserted central catheters, pyoderma gangrenosum from sites of dermal trauma, and anetoderma of prematurity from cutaneous monitoring devices in neonates. "
3.	Gas Lasers 10/01/2012 - "Pinhole carbon dioxide laser treatment of secondary anetoderma associated with juvenile xanthogranuloma."
4.	Traction 05/01/2001 - "The first patient had undergone skeletal traction around the knee and the second patient developed an apparent anetoderma of the left side of the nose. "
5.	Lasers (Laser) 04/01/2012 - "Treatment of anetoderma occurring after resolution of Stevens-Johnson syndrome using an ablative 10,600-nm carbon dioxide fractional laser."