Cysteine Proteases (Cysteine Protease)

10/22/2004 - "When used to immunise sheep, less than 3microg per dose of this cysteine proteinase fraction was found to confer a substantial and repeatable level of protection against homologous challenge infection, reducing faecal egg counts by 48 and 28% and worm burdens by 44 and 46% over two trials. "
06/01/2011 - "Cysteine proteinase type I, encapsulated in solid lipid nanoparticles induces substantial protection against Leishmania major infection in C57BL/6 mice."
01/01/2014 - "Cysteine proteinases from papaya (Carica papaya) in the treatment of experimental Trichuris suis infection in pigs: two randomized controlled trials."
12/01/2011 - "histolytica to kill and phagocytose extracellular targets during human infection and include detailed studies of the role of the parasite's cysteine proteinases and other effectors of cytotoxicity, as well as the mechanisms of ligand recognition, signaling and intracellular trafficking during phagocytosis."
11/01/2008 - "This study suggests a role for leishmanial cysteine proteinases CTE at early stages of infection."

01/01/2000 - "Cysteine proteinase inhibitor level in tumor and normal tissues in control and cured mice."
10/01/2013 - "These studies highlight the important contribution of tissue/microenvironment context to solid tumor development and indicate that tissue specificity defines functional significance for these two members of the cysteine protease family. "
02/01/1995 - "A few studies have demonstrated the enrichment of cysteine protease inhibitor activity in the membrane fraction of tumors/cells. "
01/01/2015 - "This review demonstrates that the influence of cysteine proteases on different mechanisms underlying cancer is undisputable. "
01/01/2015 - "Cysteine proteases assist migration and development of the disease, as well as increase the invasiveness of particular kinds of tumors. "

10/01/2001 - "Application of three of these inhibitors to infected erythrocytes cured malaria in culture, but parasite death did not correlate with food vacuole abnormalities associated with the activity of mechanistic inhibitors of cysteine proteases like the epoxide E64. "
01/01/2013 - "A mouse malaria model provides an unprecedented opportunity to study the roles of a parasite-encoded inhibitor of cysteine proteases (ICP) over the entire parasite life cycle. "
12/01/2011 - "In the second part (study set), the findings of the evaluation set were used to select appropriate templates to model novel cysteine protease-inhibitor complexes from human and malaria parasites Plasmodium falciparum and Plasmodium vivax. "
01/01/2002 - "Recent studies have shown that the repertoire of cysteine proteases of malaria parasites is larger than was previously realized. "
01/01/2014 - "Cysteine proteases play a crucial role in the development of the human malaria parasites Plasmodium falciparum and Plasmodium vivax. "

09/01/2007 - "Antitumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cysteine proteinase from Bromelia fastuosa."
09/01/2003 - "Invasion of melanoma cells into dermal connective tissue in vitro: evidence for an important role of cysteine proteases."
08/01/1997 - "Furthermore, in fibroblasts originating from melanoma tissue cysteine proteinase activities were increased compared to normal skin fibroblasts. "
08/01/1997 - "The melanoma cell line MEL-HO, which originated from a primary lesion, showed highest activity of an unknown cysteine proteinase. "
01/01/1992 - "A possible role for cysteine proteinase and its inhibitors in motility of malignant melanoma and other tumour cells."

08/01/2000 - "To test the efficacy of detecting anti-Schistosoma mansoni cysteine proteinase antibodies (CP Abs) by cystatin capture (CC) ELISA in the diagnosis of prepatent schistosomiasis (before egg passing); 253 schistosome negative individuals were selected and divided into two groups. "
08/01/2008 - "haematobium adult worm antigens (Ags) (SAWA), excretory/secretory Ags (E/S) and cysteine proteinase Ag (27-29 kDa) for diagnosis of schistosomiasis. "
05/01/2015 - "The pressing need for better drugs against Chagas disease, African sleeping sickness, and schistosomiasis motivates the search for inhibitors of cruzain, rhodesain, and Schistosoma mansoni CB1 (SmCB1), the major cysteine proteases from Trypanosoma cruzi, Trypanosoma brucei, and S. "
01/01/2007 - "The significant reduction in parasite burden and pathology by this vinyl sulfone cysteine protease inhibitor validates schistosome cysteine proteases as drug targets and offers the potential of a new direction for chemotherapy of human schistosomiasis."