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Aspartic Acid Proteases

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A subclass of peptide hydrolases that depend on an ASPARTIC ACID residue for their activity.

Also Known As:

Aspartyl Proteases; Acid Proteases, Aspartic; Proteases, Aspartic Acid; Proteases, Aspartyl; Proteinases, Aspartic; Proteinases, Aspartic Acid; Proteinases, Aspartyl; Aspartic Acid Proteinases; Aspartic Proteinases; Aspartyl Proteinases

Networked: 76 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Peptide Hydrolases: 7577
      - Aspartic Acid Proteases: 76
        Aspartic Acid Endopeptidases: 1
        Cryptomeria japonica cpa63 allergen

Experts

1.	Morschhäuser, Joachim: 5 articles (11/2010 - 02/2002)
2.	Hube, Bernhard: 4 articles (01/2015 - 06/2003)
3.	Staib, Peter: 4 articles (03/2005 - 02/2002)
4.	Korting, Hans C: 3 articles (04/2013 - 06/2003)
5.	Schaller, Martin: 3 articles (05/2005 - 02/2002)
6.	Korting, H C: 3 articles (10/2002 - 04/2000)
7.	Schaller, M: 3 articles (10/2002 - 04/2000)
8.	Kretschmar, Marianne: 3 articles (06/2002 - 02/2002)
9.	Nichterlein, Thomas: 3 articles (06/2002 - 02/2002)
10.	Hof, Herbert: 3 articles (06/2002 - 02/2002)

Related Diseases

1.	Infection 06/01/2004 - "Furthermore, the study of PIs against specific aspartyl proteases of those opportunistic protozoa that cause severe and intractable diseases, could be considered an alternative way towards the development of new drugs that may prove effective against these infections." 09/01/2007 - "This study demonstrates the differential expression of the secreted aspartic proteinases (Saps) genes during colonisation and VVC and RVVC infection in humans and correlates the expression of specific Candida species virulence genes with active disease and anatomical location." 04/01/2013 - "The family of secreted aspartic proteinases is known as an important virulence factor of yeast infections by Candida albicans in particular, which is the most common fungal pathogen for humans with respect to systemic disease. " 02/01/2009 - "Candida albicans secretes aspartyl proteases (Saps) during infection. " 06/01/2003 - "Secreted aspartyl proteinases (Saps) contribute to the ability of Candida albicans to cause mucosal and disseminated infections. "
2.	Candidiasis (Moniliasis) 11/01/2010 - "Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis." 05/01/2005 - "Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis." 06/01/2003 - "The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium." 10/01/2002 - "The secreted aspartic proteinases as a new target in the therapy of candidiasis." 03/01/2014 - "A family of 11 GPI (glycosylphosphatidylinositol)-linked cell surface-associated aspartyl proteases (yapsins) in the human opportunistic fungal pathogen Candida glabrata is required for cell wall remodelling, pH homoeostasis, survival in macrophages and virulence in a murine model of disseminated candidiasis. "
3.	Malaria 02/01/2006 - "A recombinant form of this enzyme was found to cleave a variety of peptide substrates and was susceptible to a selection of naturally occurring and synthetic inhibitors, displaying an inhibition profile distinct from that of aspartic proteinases from other malaria parasites. " 07/09/1999 - "Naturally-occurring and recombinant forms of the aspartic proteinases plasmepsins I and II from the human malaria parasite Plasmodium falciparum." 01/01/1995 - "Aspartic proteinases from the human malaria parasite Plasmodium falciparum." 05/27/2010 - "Four aspartyl proteases known as plasmepsins are involved in the degradation of hemoglobin by Plasmodium falciparum, which causes a large percentage of malaria deaths. " 02/01/2006 - "The rodent malaria parasite Plasmodium chabaudi encodes one food vacuole plasmepsin-the aspartic proteinases important in haemoglobin degradation. "
4.	Alzheimer Disease (Alzheimer's Disease) 05/01/2012 - "BACE1 is one of two aspartyl proteinases that generate Aβ, thus inhibition of BACE1 has the potential to ameliorate the progression of Alzheimer's disease by abating the production of Aβ. " 06/01/2002 - "That knowledge has led to the design of new inhibitors of aspartyl proteinases, which are participants in the maturation of human immunodeficiency virus and in the generation of Alzheimer's disease." 05/01/2013 - "When two novel aspartyl proteases were published in 1999 and 2000, beta-site APP-cleaving enzyme 1 (BACE1) was confirmed as the long sought after beta-secretase and Alzheimer's disease drug target. " 07/30/2010 - "BACE1 (beta-site amyloid precursor protein-cleaving enzyme 1) is a membrane-tethered member of the aspartyl proteases, essential for the production of beta-amyloid, a toxic peptide that accumulates in the brain of subjects affected by Alzheimer disease. " 01/01/2004 - "BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's disease."
5.	Acquired Immunodeficiency Syndrome (AIDS) 04/01/2002 - "The retroviral aspartic proteinases, such as the HIV proteinase, are essential for maturation of the virus particle and inhibitors have a proven therapeutic record in the treatment of AIDS. " 01/01/1999 - "Efforts to develop therapeutically relevant HIV protease inhibitors as medicinal agents in confronting the AIDS crisis have been aided by the wealth of fundamental information acquired during related drug discovery campaigns against other aspartyl proteases. " 01/01/1995 - "The model aids understanding of multiple roles played by activation peptides of aspartic proteinases and will be used as a starting model for molecular replacement." 11/01/1994 - "The aspartic proteinases are an important family of enzymes associated with several pathological conditions such as hypertension (renin), gastric ulcers (pepsin), neoplastic disease (cathepsins D and E), and AIDS (HIV proteinase). "

Related Drugs and Biologics

1.	HIV Protease Inhibitors
2.	Virulence Factors (Pathogenicity Factors)
3.	Cysteine (L-Cysteine)
4.	Amyloid Precursor Protein Secretases (beta-Secretase)
5.	Enzymes
6.	Cathepsin D
7.	Caspases
8.	HIV Protease
9.	Amyloid (Amyloid Fibrils)
10.	plasmepsin (plasmepsin I)

Related Therapies and Procedures

1.	Highly Active Antiretroviral Therapy (HAART)
2.	Therapeutics