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Vasoplegia

Condition of low SYSTEMIC VASCULAR RESISTANCE that develops secondary to other conditions such as ANAPHYLAXIS; SEPSIS; SURGICAL SHOCK; and SEPTIC SHOCK. Vasoplegia that develops during or post surgery (e.g., CARDIOPULMONARY BYPASS) is called postoperative vasoplegic syndrome or vasoplegic syndrome.
Also Known As:
Post operative Vasoplegic Syndrome; Post-operative Vasoplegic Syndromes; Syndrome, Post-operative Vasoplegic; Syndromes, Post-operative Vasoplegic; Vasoplegias; Vasoplegic Syndrome, Post-operative; Vasoplegic Syndromes, Post-operative; Post-operative Vasoplegic Syndrome; Postoperative Vasoplegic Syndrome; Vasoplegic Syndrome
Networked: 377 relevant articles (21 outcomes, 36 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hypotension (Low Blood Pressure)
2. Shock
3. Acute Kidney Injury (Acute Renal Failure)
4. Methemoglobinemia
5. Poisoning

Experts

1. Evora, Paulo Roberto Barbosa: 8 articles (01/2018 - 10/2006)
2. Rodrigues, Alfredo José: 7 articles (01/2016 - 10/2006)
3. Evora, Paulo Roberto B: 6 articles (10/2022 - 03/2004)
4. Abou-Arab, Osama: 5 articles (07/2022 - 05/2017)
5. Guinot, Pierre-Grégoire: 5 articles (07/2022 - 05/2017)
6. Palmen, Meindert: 5 articles (01/2022 - 09/2013)
7. Pagel, Paul S: 5 articles (12/2019 - 12/2016)
8. Boettcher, Brent T: 5 articles (01/2018 - 12/2016)
9. Fischer, Gregory W: 5 articles (01/2016 - 10/2009)
10. Celotto, Andrea Carla: 4 articles (10/2022 - 07/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vasoplegia:
1. Methylene Blue (Methylthioninium Chloride)FDA Link
2. Vasopressins (Vasopressin)IBA
3. HydroxocobalaminFDA Link
4. Norepinephrine (Noradrenaline)FDA LinkGeneric
5. Angiotensin IIIBA
6. Ascorbic Acid (Vitamin C)FDA LinkGeneric
7. Guanylate Cyclase (Guanylyl Cyclase)IBA
07/01/2009 - "There is strong evidence that methylene blue (MB), an inhibitor of guanylate cyclase, is an excellent therapeutic option for vasoplegic syndrome (VS) treatment in heart surgery. "
06/01/2003 - "Guanylate cyclase inhibitors could be a novel class of agents for the treatment of norepinephrine-refractory vasoplegia after cardiopulmonary bypass. "
05/01/2012 - "Guanylate cyclase inhibition by methylene blue as an option in the treatment of vasoplegia after a severe burn. "
01/01/2008 - "Thus, some points, to a certain extent philosophical, have motivated this revision: a) To preserve and update the surgeon knowledge regarding CPB, even to keep his/her pedagogical leadership on his/her surgical team; b) To question if elderly and diabetic patients, as a result of their individual characteristics deserve more appropriate protocols similar to those adopted for children; c) One third aspect would be the questioning of the systemic inflammatory reaction caused by the blood exposure to CPB non-endothelized circuit surface, in face of the increasing importance of blood contact with the surgical wound; d) In relation to the treatment of the vasoplegic syndrome, methylene blue continues being the best therapeutical option, even so, many times are not efficient on account of a highly probable existence of a "therapeutical window" based on the guanylate cyclase dynamics of action (saturation and synthesis "de novo") and; finally, e) The reason of the title, highlighting that based on its current patterns, would the CPB be an outcome of empiricism, art, or science? "
05/01/2012 - "This article has 3 main objectives: 1) to study the guanylate cyclase inhibition by MB in burns; 2) to suggest MB as a viable, safe and useful co-adjuvant therapeutic tool of fluid resuscitation, and; 3) to suggest MB as burns hypotensive vasoplegia amine-resistant treatment.<br />"
8. CytokinesIBA
9. CalciumIBA
10. Soluble Guanylyl CyclaseIBA

Therapies and Procedures

1. Cardiopulmonary Bypass (Heart-Lung Bypass)
2. Therapeutics
3. Liver Transplantation
4. Extracorporeal Membrane Oxygenation
5. Combined Modality Therapy