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Co-Repressor Proteins

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A subclass of repressor proteins that do not directly bind DNA. Instead, co-repressors generally act via their interaction with DNA-BINDING PROTEINS such as a TRANSCRIPTIONAL SILENCING FACTORS or NUCLEAR RECEPTORS.

Also Known As:

Co-Repressors; Corepressor Proteins; Corepressors; Nuclear Hormone Receptor Co-Repressors; Nuclear Receptor Co-Repressors; Nuclear Receptor Corepressors; Co Repressor Proteins; Co Repressors; Co-Repressors, Nuclear Receptor; Corepressors, Nuclear Receptor; Nuclear Hormone Receptor Co Repressors; Nuclear Receptor Co Repressors; Receptor Co-Repressors, Nuclear

Networked: 135 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Transcription Factors: 20597
    - Repressor Proteins: 32
      - Co-Repressor Proteins: 135
        Nuclear Receptor Co-Repressor 1: 14
        Nuclear Receptor Co-Repressor 2: 10
        DAX-1 Orphan Nuclear Receptor: 8
        Sin3 Histone Deacetylase and Corepressor Complex: 1
        Drosophila Smr protein
        human C1D protein
        human NKAP protein
        Xenopus TLE4 protein

Experts

1.	Campbell, Moray J: 5 articles (07/2013 - 09/2004)
2.	Hiebert, Scott W: 4 articles (01/2012 - 03/2003)
3.	Baniahmad, Aria: 3 articles (01/2011 - 02/2005)
4.	Vemuganti, Raghu: 2 articles (12/2015 - 01/2013)
5.	Saunthararajah, Yogen: 2 articles (05/2014 - 06/2011)
6.	Gu, Xiaorong: 2 articles (05/2014 - 06/2011)
7.	Hu, Zhenbo: 2 articles (05/2014 - 06/2011)
8.	Guo, Chun: 2 articles (01/2014 - 01/2014)
9.	Zhang, Jinsong: 2 articles (01/2014 - 01/2014)
10.	Turner, Bryan M: 2 articles (07/2013 - 09/2004)

Related Diseases

1.	Fibrosis (Cirrhosis) 12/01/2003 - "Therefore, new strategy aimed to increase Smad transcriptional co-repressors expression may be effective in antagonizing TGF-beta1 signaling and thereby blocking the progression of chronic renal fibrosis."
2.	Neoplasms (Cancer) 09/01/2014 - "The present study shows that NRP/B acts as a transcriptional repressor by interacting with the co-repressors, HDAC1, providing new insight into the molecular mechanisms of NRP/B on tumor suppression." 01/01/2014 - "While the current studies support the view that the corepressors are promising targets for cancer treatment, elucidation of the mechanisms of corepressors involved in individual types of cancers is likely required for effective therapy. " 04/01/2013 - "These transcriptional corepressors and tumor suppressors inhibit the expression of cellular or viral genes that are required for efficient viral replication. " 03/15/2013 - "Transcriptional corepressors in cancer: emerging targets for therapeutic intervention." 10/01/2012 - "Transcriptional repressors and corepressors play a critical role in cellular homeostasis and are frequently altered in cancer. "
3.	Prostatic Neoplasms (Prostate Cancer) 10/01/2011 - "In this study we compared the effects of two known co-repressors, NCoR and SMRT, on AR transcriptional activity in prostate cancer (PCa) cell lines and compared them to that in COS-1 cells. " 12/01/2009 - "This study provides proof of principle that i) reduction in PHB promotes both androgen-dependent and 'androgen-independent' tumour growth, and ii) altering AR activity via increasing levels or activity of corepressors is a valid therapeutic strategy for advanced prostate cancer." 11/15/2014 - "Consistent with its function as a transcriptional corepressor, CtBP2 repressed tumor-suppressor genes and AR corepressors in prostate cancer cells, such as NCOR and RIP140, by binding with AR to the promoter enhancers of these genes. " 08/01/2013 - "There is a competition between coactivators and corepressors for binding on the AR and therefore the changes in coregulators expression and ratio could be important for prostate cancer survival. " 08/01/2013 - "Coregulators, coactivators as well as corepressors, play an important role in AR-mediated growth and progression of prostate cancer. "
4.	Breast Neoplasms (Breast Cancer) 01/04/2013 - "ERα, a critical transcriptional factor for breast cancer proliferation, is regulated by a complex binding repertoire that includes coactivators and corepressors. " 02/01/2000 - "However, the substantial roles of ER-beta, coactivators, and corepressors in the development and progression of breast cancer remain to be elucidated. " 12/01/2003 - "In this review, we present evidence from tissue culture, animal and clinical studies, supporting the hypothesis that corepressors are crucial regulators of ERalpha-mediated action, and that their loss could promote breast cancer development and resistance to endocrine therapy. " 12/02/2002 - "This study addresses the hypothesis that altered expression of oestrogen receptor-beta and/or altered relative expression of coactivators and corepressors of oestrogen receptors are associated with and may be mechanisms of de novo tamoxifen resistance in oestrogen receptor positive breast cancer. " 12/01/2003 - "Estrogen receptor corepressors -- a role in human breast cancer?"
5.	Leukemia 05/23/2014 - "Thus, RUNX1 and PU.1 cooperate to exchange corepressors for coactivators, and the specific corepressors recruited to PU.1 as a consequence of RUNX1 deficiency could be rational targets for leukemia differentiation therapy. " 09/01/2010 - "The promyelocytic leukemia zinc finger (Plzf) gene containing an evolutionary conserved BTB (bric-a-brac/tramtrack/broad complex) domain plays a key role in self-renewal of mammalian spermatogonial stem cells (SSCs) via recruiting transcriptional co-repressors. " 12/01/1999 - "FAZF is homologous to the promyelocytic leukemia zinc finger (PLZF) protein, which has been shown to act as a transcriptional repressor by recruitment of nuclear corepressors (N-CoR, Sin3, and HDAC1 complex). " 12/01/1998 - "ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors." 06/16/2011 - "Runx1 deficiency decreased Pu.1-mediated activation of Mcsfr and Gmcsfr, accompanied by decreased histone acetylation at the Mcsfr and Gmcsfr promoters, and increased endogenous corepressor (Eto2, Sin3A, and Hdac2) coimmunoprecipitation with Pu.1. In cotransfection experiments, corepressors were excluded from a multiprotein complex containing full-length RUNX1 and PU.1. However, corepressors interacted with PU.1 if wild-type RUNX1 was replaced with truncated variants associated with leukemia. "

Related Drugs and Biologics

1.	Transforming Growth Factor beta1 (TGF beta 1)
2.	Proteins (Proteins, Gene)
3.	Carbon Monoxide
4.	Estrogen Receptor alpha
5.	Tamoxifen
6.	Androgens
7.	Estrogen Receptor Modulators (Antiestrogen)
8.	Tretinoin (Retinoic Acid)
9.	Histone Deacetylases (Histone Deacetylase)
10.	Estrogens (Estrogen)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Castration