ARNTL Transcription Factors
Basic helix-loop-helix (bHLH) domain-containing proteins that play important roles in CIRCADIAN RHYTHM regulation. They combine with CLOCK PROTEINS to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation.
Also Known As:
ARNTL1 Protein; ARNTL2 Protein; Aryl Hydrocarbon Receptor Nuclear Translocator-like 1 Protein; Aryl Hydrocarbon Receptor Nuclear Translocator-like 2 Protein; Aryl Hydrocarbon Receptor Nuclear Translocator-like Protein 1; Aryl Hydrocarbon Receptor Nuclear Translocator-like Transcription Factors; BMAL1 Protein; BMAL2 Protein; Brain and Muscle ARNT-like 2 Protein; Brain and Muscle ARNT-like Proteins; Brain and muscle ARNT-like 1 Protein; MOP3 Transcription Factor; MOP9 Transcription Factor; Member of PAS Protein 3; Member of PAS Protein 9; Aryl Hydrocarbon Receptor Nuclear Translocator like 1 Protein; Aryl Hydrocarbon Receptor Nuclear Translocator like 2 Protein; Aryl Hydrocarbon Receptor Nuclear Translocator like Protein 1; Aryl Hydrocarbon Receptor Nuclear Translocator like Transcription Factors; Brain and Muscle ARNT like 2 Protein; Brain and Muscle ARNT like Proteins; Brain and muscle ARNT like 1 Protein; Transcription Factor, MOP9; Transcription Factors, ARNTL
Networked: 15
relevant articles (1 outcomes,
1 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Chen, Gang:
1 article
(01/2022)
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2. | Gao, Rong:
1 article
(01/2022)
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3. | Li, Bing:
1 article
(01/2022)
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4. | Li, Di:
1 article
(01/2022)
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5. | Liu, Chenglin:
1 article
(01/2022)
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6. | Liu, Huixiang:
1 article
(01/2022)
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7. | Ni, Haibo:
1 article
(01/2022)
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8. | Xiong, Jian:
1 article
(01/2022)
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9. | Zhang, Li:
1 article
(01/2022)
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10. | Li, Siyuan:
1 article
(12/2021)
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Related Diseases
1. | Hypertension (High Blood Pressure)
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2. | Neurocognitive Disorders (Clerambault Syndrome)
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3. | Neoplasms (Cancer)
10/01/2022
- " Immunohistochemical staining was used to detect the expression of BMAL1 protein in transplanted tumors. " 01/01/2018
- " Importantly, we demonstrate that the expression of the clock gene aryl hydrocarbon receptor nuclear translocator-like protein 1 (BMAL1) positively correlates with patient overall survival and with the expression of T-cell activity and exhaustion markers in the tumor bulk. " 01/01/2018
- " Level of BMAL1 protein was also reduced in tumor tissues and BMAL1 expression was associated with better 1-, 3- and 5-year overall survival (OS) of cancer patients (92.6%, 69.2% and 62.3% versus 59.1%, 40.9% and 0% in patients with low BMAL1 expressed tumors; p = 0.000). " 01/01/2019
- " These include 5'-AMP-activated protein kinase catalytic subunit α2 (AMPKα2), tumor suppressor ubiquitin carboxyl-terminal hydrolase BAP1, mixed-lineage leukemia (MLL) protein, SMAD family member 6 (SMAD6), transcription factor c-Maf and aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL or BMAL1), and free ribosomal proteins, which are ubiquitinated in distinct ways, thereby associating UBE2O with a variety of biological functions. "
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4. | Premature Aging
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5. | Weight Loss (Weight Reduction)
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Related Drugs and Biologics
Related Therapies and Procedures