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CLOCK Proteins

Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
Also Known As:
CLOCK Protein; Circadian Locomotor Output Cycles Kaput Proteins
Networked: 57 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Gibbs, Julie E: 4 articles (12/2020 - 11/2016)
2. Ray, David W: 4 articles (12/2020 - 11/2016)
3. Begley, Nicola: 3 articles (12/2020 - 01/2020)
4. Blaikley, John F: 3 articles (12/2020 - 01/2020)
5. Durrington, Hannah J: 3 articles (12/2020 - 01/2020)
6. Loudon, Andrew S I: 2 articles (12/2020 - 11/2016)
7. Maidstone, Robert: 2 articles (12/2020 - 01/2020)
8. Meijer, Peter: 2 articles (12/2020 - 01/2020)
9. Hikima, Jun-Ichi: 2 articles (10/2020 - 10/2020)
10. Kono, Tomoya: 2 articles (10/2020 - 10/2020)

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4. Infarction (Infarctions)
5. Brain Edema (Cerebral Edema)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Messenger RNA (mRNA)
3. Phosphotransferases (Kinase)
4. Ribosomal Protein S6
5. Glucocorticoids
6. Nexus
7. ARNTL Transcription Factors
8. Cryptochromes
9. Sirtuin 1
10. beta Catenin

Related Therapies and Procedures

1. Rewarming
2. Therapeutics