Nuclear Receptor Coactivator 3

A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS and PROGESTERONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in CHROMATIN REMODELING during the process of nuclear receptor-induced transcription. The coactivator has been found at elevated levels in certain HORMONE-DEPENDENT NEOPLASMS such as those found in BREAST CANCER.

Also Known As:

Networked: 45 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	O'Malley, Bert W: 11 articles (01/2021 - 09/2005)
2.	Xu, Jianming: 8 articles (01/2017 - 09/2005)
3.	Lonard, David M: 6 articles (01/2021 - 05/2012)
4.	Yu, Chundong: 6 articles (12/2015 - 12/2006)
5.	Yu, Yang: 3 articles (01/2021 - 01/2014)
6.	Chen, Qiang: 3 articles (01/2014 - 11/2010)
7.	Qin, Li: 2 articles (01/2021 - 01/2015)
8.	Chen, Miao: 2 articles (11/2020 - 01/2018)
9.	Deng, Wuguo: 2 articles (11/2020 - 01/2018)
10.	Li, Liren: 2 articles (11/2020 - 01/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "Steroid receptor coactivator 3 is a key modulator of regulatory T cell-mediated tumor evasion." 11/25/2020 - "Here, we have identified nuclear receptor coactivator-3 (NCOA3) as a new modulator of TERT expression and tumor growth in HCC. " 05/01/2023 - "Nuclear receptor coactivator 3 (NCoA3) is a transcriptional coactivator of NF‑κB and other factors, which is expressed at relatively low levels in normal cells and is amplified or overexpressed in several types of cancer, including breast tumors. " 01/01/2018 - "Nuclear receptor coactivator 3 (NCOA3) is a transcriptional coactivator that has elevated expression in multiple tumor types, including colorectal cancer (CRC). " 01/01/2017 - "The steroid receptor coactivator 3 (SRC-3) is overexpressed in a wide range of cancers, driving tumor initiation, cell proliferation, and metastasis. "
2.	Breast Neoplasms (Breast Cancer) 07/01/2008 - "Overexpression of steroid receptor coactivator 3 (SRC-3) is associated with an increased incidence of breast cancer. " 05/01/2023 - "Nuclear receptor coactivator 3 (NCoA3) is a transcriptional coactivator of NF‑κB and other factors, which is expressed at relatively low levels in normal cells and is amplified or overexpressed in several types of cancer, including breast tumors. " 01/01/2021 - "Steroid receptor coactivator 3 (SRC-3/NCoA3/AIB1), is a key regulator of gene transcription and it plays a central role in breast cancer (BC) tumorigenesis, making it a potential therapeutic target. " 07/23/2015 - "Amplified in breast cancer 1 (AIB1), also known as steroid receptor coactivator 3 or NCOA3, is a transcriptional coactivator that promotes cancer cell proliferation and invasiveness. " 06/01/2012 - "SRC-3/AIB1 (steroid receptor coactivator 3/amplified in breast cancer 1) is an authentic oncogene that contributes to the development of drug resistance and poor disease-free survival in cancer patients. "
3.	Inflammation (Inflammations) 11/01/2010 - "Steroid receptor coactivator 3 (SRC-3) is a multifunctional protein that plays an important role in regulation of bacterial LPS-induced inflammation. " 01/01/2014 - "Steroid receptor coactivator 3 (SRC-3) is a multifunctional protein that plays an important role in malignancy of several cancers and in regulation of bacterial LPS-induced inflammation. " 01/01/2018 - "Previous studies have shown that steroid receptor coactivator 3 (SRC-3) interacts with estrogen receptors (ERs) which are involved in the vasoprotective effects of estrogen and is also associated with cell migration, invasion, and inflammation; however, its role in PE remains unclear. "
4.	Arthritis (Polyarthritis) 01/01/2023 - "In this study, we discovered overexpression of nuclear receptor coactivator 3 (NCOA3) in the joint tissues of type II collagen-induced arthritis (CIA) mice, an important autoimmune model of human RA. "
5.	Hypoxia (Hypoxemia) 11/01/2022 - "In the current study, we found that hypoxia stimulus easily induced chemoresistance to proteasome inhibitors (PIs), and the steroid receptor coactivator 3 (SRC-3) expression was remarkably augmented at posttranslational level. "

Related Drugs and Biologics

1.	Estrogen Receptors
2.	Proteasome Inhibitors
3.	Heme Oxygenase-1
4.	Collagen Type II (Type II Collagen)
5.	Paclitaxel (Taxol)
6.	Steroid Receptors (Steroid Receptor)
7.	Estrogens (Estrogen)
8.	Proteins (Proteins, Gene)
9.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
10.	Transcription Factors (Transcription Factor)