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Mediator Complex Subunit 1

A mediator complex subunit that is believed to play a key role in the coactivation of nuclear receptor-activated transcription by the mediator complex. It interacts with a variety of nuclear receptors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; VITAMIN D RECEPTORS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; ESTROGEN RECEPTORS; and GLUCOCORTICOID RECEPTORS.
Also Known As:
DRIP205; Mediator of RNA Polymerase II Transcription Subunit 1; PPAR-Binding Protein; Peroxisome Proliferator-Activated Receptor Binding Protein; RB18A; TR-Associated Protein P220; TRAP220; TRIP2 (Thyroid Receptor Interacting Protein 2); Thyroid Hormone Receptor Associated Protein 220; Thyroid Receptor Interacting Protein 2; Vitamin D Receptor-Interacting Protein Complex Component DRIP205; p53 Regulatory Protein RB18A; PPAR Binding Protein; Peroxisome Proliferator Activated Receptor Binding Protein; TR Associated Protein P220; Vitamin D Receptor Interacting Protein Complex Component DRIP205
Networked: 31 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Yun, Jeanho: 4 articles (06/2017 - 03/2011)
2. Roh, Mee Sook: 3 articles (01/2016 - 03/2011)
3. Kim, Hyun-Ju: 2 articles (06/2017 - 08/2012)
4. Son, Choon Hee: 2 articles (08/2012 - 03/2011)
5. Safe, Stephen: 2 articles (06/2010 - 12/2004)
6. Roeder, Robert G: 2 articles (12/2005 - 07/2005)
7. Devor, Eric J: 1 article (12/2022)
8. Santillan, Donna A: 1 article (12/2022)
9. Santillan, Mark K: 1 article (12/2022)
10. Scroggins, Sabrina M: 1 article (12/2022)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Colorectal Neoplasms (Colorectal Cancer)
4. Bacterial Infections (Bacterial Infection)
5. Non-alcoholic Fatty Liver Disease
12/01/2021 - ": BAF: bafilomycin A1; db/db mice; Leprdb/db mice; ECAR: extracellular acidification rate; KD: knockdown; MED1: mediator complex subunit 1; NAFLD: nonalcoholic fatty liver disease; OCR: oxygen consumption rate; PPARA/PPARα: peroxisomal proliferator activated receptor alpha; TF: transcription factor; TFEB: transcription factor EB; tf-LC3: tandem fluorescence RFP-GFP-LC3; TG: triglyceride; TH: Thyroid hormone; TR: thyroid hormone receptors; V-ATPase: vacuolar-type H+-ATPase; WDF: Western diet with 15% fructose in drinking water."
09/12/2023 - "ACOX1: acyl-CoA oxidase 1; ADH5: alcohol dehydrogenase 5 (class III), chi polypeptide; ADIPOQ: adiponectin, C1Q and collagen domain containing; ATG: autophagy related; BECN1: beclin 1; CRTC2: CREB regulated transcription coactivator 2; ER: endoplasmic reticulum; F2RL1: F2R like trypsin receptor 1; FA: fatty acid; FOXO1: forkhead box O1; GLP1R: glucagon like peptide 1 receptor; GRK2: G protein-coupled receptor kinase 2; GTPase: guanosine triphosphatase; HFD: high-fat diet; HSCs: hepatic stellate cells; HTRA2: HtrA serine peptidase 2; IRGM: immunity related GTPase M; KD: knockdown; KDM6B: lysine demethylase 6B; KO: knockout; LAMP2: lysosomal associated membrane protein 2; LAP: LC3-associated phagocytosis; LDs: lipid droplets; Li KO: liver-specific knockout; LSECs: liver sinusoidal endothelial cells; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAP3K5: mitogen-activated protein kinase kinase kinase 5; MED1: mediator complex subunit 1; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin complex 1; NAFLD: non-alcoholic fatty liver disease; NASH: non-alcoholic steatohepatitis; NFE2L2: NFE2 like bZIP transcription factor 2; NOS3: nitric oxide synthase 3; NR1H3: nuclear receptor subfamily 1 group H member 3; OA: oleic acid; OE: overexpression; OSBPL8: oxysterol binding protein like 8; PA: palmitic acid; RUBCNL: rubicon like autophagy enhancer; PLIN2: perilipin 2; PLIN3: perilipin 3; PPARA: peroxisome proliferator activated receptor alpha; PRKAA2/AMPK: protein kinase AMP-activated catalytic subunit alpha 2; RAB: member RAS oncogene family; RPTOR: regulatory associated protein of MTOR complex 1; SCD: stearoyl-CoA desaturase; SIRT1: sirtuin 1; SIRT3: sirtuin 3; SNARE: soluble N-ethylmaleimide-sensitive factor attachment protein receptor; SQSTM1/p62: sequestosome 1; SREBF1: sterol regulatory element binding transcription factor 1;SREBF2: sterol regulatory element binding transcription factor 2; STING1: stimulator of interferon response cGAMP interactor 1; STX17: syntaxin 17; TAGs: triacylglycerols; TFEB: transcription factor EB; TP53/p53: tumor protein p53; ULK1: unc-51 like autophagy activating kinase 1; VMP1: vacuole membrane protein 1."

Related Drugs and Biologics

1. Mediator Complex Subunit 1
2. Estrogens (Estrogen)
3. MicroRNAs (MicroRNA)
4. human MIRN137 microRNA
5. Proteins (Proteins, Gene)
6. PPAR gamma
7. PPAR alpha
8. Peroxisome Proliferator-Activated Receptors (PPAR)
9. Triglycerides (Triacylglycerol)
10. Transcription Factors (Transcription Factor)

Related Therapies and Procedures

1. Therapeutics