Binge-Eating Disorder (Binge Eating Disorder)

A disorder associated with three or more of the following: eating until feeling uncomfortably full; eating large amounts of food when not physically hungry; eating much more rapidly than normal; eating alone due to embarrassment; feeling of disgust, DEPRESSION, or guilt after overeating. Criteria includes occurrence on average, at least 2 days a week for 6 months. The binge eating is not associated with the regular use of inappropriate compensatory behavior (i.e. purging, excessive exercise, etc.) and does not co-occur exclusively with BULIMIA NERVOSA or ANOREXIA NERVOSA. (From DSM-IV, 1994)

Also Known As:

Networked: 634 relevant articles (66 outcomes, 180 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Bulimia Nervosa
2.	Bulimia (Binge Eating)
3.	Weight Loss (Weight Reduction)
4.	Feeding and Eating Disorders (Eating Disorder)
5.	Anorexia Nervosa

Experts

1.	McElroy, Susan L: 45 articles (11/2021 - 03/2002)
2.	Guerdjikova, Anna I: 22 articles (11/2021 - 02/2005)
3.	Hudson, James I: 22 articles (10/2021 - 11/2002)
4.	Grilo, Carlos M: 20 articles (12/2021 - 02/2005)
5.	Keck, Paul E: 19 articles (02/2018 - 03/2002)
6.	Mitchell, James E: 16 articles (01/2020 - 01/2002)
7.	Mori, Nicole: 13 articles (11/2021 - 01/2011)
8.	Bulik, Cynthia M: 11 articles (01/2022 - 04/2006)
9.	Maj, Mario: 11 articles (12/2017 - 11/2003)
10.	Monteleone, Palmiero: 11 articles (12/2017 - 11/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Binge-Eating Disorder:

1.	Lisdexamfetamine DimesylateFDA Link 01/01/2023 - "With the exception of lisdexamfetamine (Vyvanse) for binge eating disorder, no medications have been effective for the core symptoms of ED. " 10/01/2022 - "Lisdexamfetamine dimesylate (LDX) is the only drug currently approved by the FDA for the treatment of Binge-Eating Disorder (BED), but little is known about the behavioural mechanisms that underpin the efficacy of LDX in treating BED. " 04/01/2015 - "Lisdexamfetamine for binge eating disorder in adults: a systematic review of the efficacy and safety profile for this newly approved indication - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?" 01/01/2017 - "Efficacy of Lisdexamfetamine in Adults With Moderate to Severe Binge-Eating Disorder: A Randomized Clinical Trial." 01/01/2021 - "This study examined Sheehan Disability Scale (SDS) performance in binge eating disorder (BED) and explored relationships between SDS and BED outcomes using data from three placebo-controlled lisdexamfetamine (LDX) studies (two short-term, dose-optimized studies and one double-blind, randomized-withdrawal study) in adults with Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision (DSM-IV-TR)-defined BED. "
2.	Topiramate (Topamax)FDA LinkGeneric 05/01/2000 - "Topiramate may be an effective treatment for binge-eating disorder. " 10/01/2021 - "To assess the efficacy and safety of topiramate in treating binge eating disorder (BED), using a systematic review and meta-analysis of the available randomized clinical trials (RCTs). " 01/01/2020 - "An Innovative Disease-Drug-Trial Framework to Guide Binge Eating Disorder Drug Development: A Case Study for Topiramate." 09/01/2007 - "Double-blind, randomized, placebo-controlled trial of topiramate plus cognitive-behavior therapy in binge-eating disorder." 04/01/2002 - "Topiramate use in obese patients with binge eating disorder: an open study."
3.	Fluoxetine (Prozac)FDA LinkGeneric 02/01/2005 - "Efficacy of cognitive behavioral therapy and fluoxetine for the treatment of binge eating disorder: a randomized double-blind placebo-controlled comparison." 11/01/2004 - "The diverse effects of fluoxetine on the type of food, and in hungry versus sated rats, suggest alternate brain mechanisms should be concomitantly targeted for improved treatment of binge eating disorders." 07/01/2007 - "This study assessed the long-term effects of group behavioral treatment plus individual cognitive behavioral therapy (CBT) and/or fluoxetine in binge eating disorder (BED) patients. " 11/01/2002 - "The purpose of this study was to assess the efficacy and safety of fluoxetine in the treatment of binge-eating disorder. " 11/01/2002 - "A placebo-controlled, randomized trial of fluoxetine in the treatment of binge-eating disorder."
4.	Antidepressive Agents (Antidepressants)IBA 04/01/2003 - "The findings from this small trial contribute to the inconsistent results of antidepressant studies in binge eating disorder." 01/01/1996 - "This paper reviews the findings of these studies and offers clinical guidelines for the use of antidepressants in binge-eating disorder." 01/01/2022 - "Most guidelines for binge-eating disorder (based on the limited available research) recommend forms of cognitive psychotherapies and antidepressants. " 04/01/2008 - "To evaluate the effects of antidepressant interventions for patients with Binge Eating Disorder (BED). " 04/01/2008 - "Antidepressants in short-term treatment of binge eating disorder: systematic review and meta-analysis."
5.	sibutramine (Meridia)FDA Link 01/01/2005 - "The findings suggest sibutramine is an effective medication in the treatment of binge-eating disorders and is well tolerated. " 01/01/2008 - "This study is the first large-scale, multisite, placebo-controlled trial to test the efficacy of sibutramine in binge eating disorder. " 01/01/2008 - "Efficacy of sibutramine for the treatment of binge eating disorder: a randomized multicenter placebo-controlled double-blind study." 01/01/2005 - "In this randomized, double-blind, placebo-controlled study, the efficacy, safety, and tolerability of sibutramine were evaluated in the treatment of binge-eating disorder in obese patients. " 11/01/2003 - "A randomized, double-blind, placebo-controlled study of sibutramine in the treatment of binge-eating disorder."
6.	Norepinephrine (Noradrenaline)FDA LinkGeneric 10/14/2021 - "Pharmacological studies have documented the efficacy of noradrenaline-modulating therapies in the treatment of BN and Binge Eating Disorder (BED). " 11/08/2023 - "This study investigates the central noradrenaline system by using hybrid brain imaging in conjunction with emotion regulation as a putative core biological mechanism in individuals with obesity with or without binge-eating disorder that is targeted by emotion regulation intervention. " 12/01/2005 - "The objective of this study was to evaluate the effectiveness and safety of reboxetine, a selective noradrenaline reuptake inhibitor, in the treatment of obese patients with binge eating disorder (BED). " 01/01/2005 - "Use of sibutramine, an inhibitor of the reuptake of serotonin and noradrenaline, in the treatment of binge eating disorder: a placebo-controlled study." 01/01/2005 - "Sibutramine, a new serotonin and norepinephrine reuptake inhibitor, has been shown in short- and long-term studies to be effective in promoting and maintaining weight loss in obese patients who have binge-eating disorder. "
7.	Serotonin (5 Hydroxytryptamine)IBA 07/01/2004 - "While fewer studies have been done in BN or binge eating disorder, there may be disturbances of serotonin metabolism in similar brain regions. " 10/01/2003 - "Obese women with binge-eating disorder (OB-BED) were recently found to have reduced 5-HT transporter binding. " 01/01/1996 - "Recent studies have suggested that antidepressants, particularly serotonin selective reuptake inhibitors, may be effective in the treatment of binge-eating disorder. " 01/01/2005 - "Use of sibutramine, an inhibitor of the reuptake of serotonin and noradrenaline, in the treatment of binge eating disorder: a placebo-controlled study." 01/01/2005 - "Sibutramine, a new serotonin and norepinephrine reuptake inhibitor, has been shown in short- and long-term studies to be effective in promoting and maintaining weight loss in obese patients who have binge-eating disorder. "
8.	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 09/01/2007 - "Selective serotonin reuptake inhibitors have a proven efficacy in BN and binge eating disorder. " 11/01/2000 - "Selective serotonin reuptake inhibitors (SSRIs) control the binge urges in binge-eating disorder, but more trials are required to investigate the utility of SSRIs and other agents in maintenance treatment. " 08/01/2008 - "Previous studies support the use of selective serotonin reuptake inhibitors (SSRIs), in overweight patients with Binge Eating Disorder (BED), but results are far from conclusive. " 04/01/2008 - "Regarding binge eating disorder (BED), adult literature shows positive short-term effects on binge eating for both pharmacological (especially selective serotonin reuptake inhibitors) and behavioural interventions, but unclear effects on weight. " 01/01/2004 - "Current drug treatment of patients with bulimia nervosa and binge-eating disorder: selective serotonin reuptake inhibitors versus mood stabilizers."
9.	Anti-Obesity Agents (Antiobesity Drugs)IBA 01/01/2002 - "There are scant data about the efficacy of the novel antiobesity agents for binge-eating disorder. " 01/01/2008 - "Preliminary evidence suggests that the antiobesity agent sibutramine is effective in the treatment of binge eating disorder, impacting both binge eating and weight. " 11/01/2003 - "Although antidepressants are the pharmacological agents most often studied in the treatment of binge-eating disorder (BED), preliminary evidence from an open trial suggests that the antiobesity agent sibutramine hydrochloride may be effective. " 01/01/2015 - "The data emerging from this study seem to show that, at least in the short term, some specific medications within the classes of antidepressants, anticonvulsants, and antiobesity agents may prove promising in achieving the main objectives in the treatment of binge eating disorder: reducing the frequency of binge eating, reducing weight, and improving the associated psychopathology. " 07/01/2005 - "A new anti-obesity drug treatment: first clinical evidence that, antagonising glutamate-gated Ca2+ ion channels with memantine normalises binge-eating disorders."
10.	Glucose (Dextrose)FDA LinkGeneric 01/01/2023 - "However, it is still unknown whether longan fruit supplementation can ameliorate glucose homeostasis and binge eating disorder found in T2DM. " 12/01/2015 - "To evaluate whether obese patients with a binge eating disorder (BED) have an altered metabolic and inflammatory profile related to their eating behaviors compared with non-BED obese.A total of 115 White obese patients consecutively recruited underwent biochemical, anthropometrical evaluation, and a 75-g oral glucose tolerance test. " 12/01/1995 - "This is the first description of a lack of postprandial elevation in CSF glucose concentration in a patient with a binge eating disorder. " 01/01/2013 - "We report the case of a 61-year-old woman with comorbid binge-eating disorder (BED), BP depression, and treatment-resistant type 2 diabetes mellitus (T2DM), in which LMG showed significant efficacy against BED and BP depression and resulted in a drastic decrease in plasma glucose levels. " 01/01/2014 - "Obese adolescents with subclinical binge eating disorder did not have significantly different levels of appetite signaling proteins or glucose. "

Therapies and Procedures

1.	Therapeutics 02/01/2005 - "Cognitive behavioral therapy (CBT) and certain medications have been shown to be effective for binge eating disorder (BED), but no controlled studies have compared psychological and pharmacological therapies. " 11/01/2013 - "This study examined the efficacy of guided self-help based on dialectical behaviour therapy (DBTgsh) for binge eating disorder (BED). " 12/01/2020 - "To examine changes in hypothesized maintenance mechanisms during treatment as predictors of treatment response durability in binge-eating disorder (BED) treatment, using data from a randomized clinical trial comparing the efficacy of Integrative Cognitive-Affective Therapy for BED with cognitive-behavioral therapy delivered using guided self-help. " 03/01/2012 - "To examine the long-term efficacy of out-patient group cognitive-behavioural therapy (CBT) and group interpersonal psychotherapy (IPT) for binge eating disorder and to analyse predictors of long-term non-response. " 12/01/2022 - "In this study, we investigated how patients with binge eating disorder (BED) experienced therapeutic writing and AC in the context of cognitive behavioural therapy. "
2.	Drug Therapy (Chemotherapy) 06/27/2023 - "Certain treatments have demonstrated acute efficacy for binge-eating disorder (BED) but there is a dearth of controlled research examining pharmacotherapies as maintenance treatments for responders to initial interventions. " 03/01/2014 - "This study evaluated controlled treatment studies of pharmacotherapy for binge eating disorder (BED). " 09/01/2008 - "This study evaluated available controlled treatment studies to determine utility of pharmacotherapy for binge-eating disorder (BED). " 01/01/2022 - "QUALITÉ DES DONNÉES: Une recension a été effectuée dans PubMed, PsycInfo et Google Scholar, sans restrictions temporelles, à l’aide des expressions clés en anglais binge eating disorder, treatment, review, guidelines, psychotherapy, primary care et pharmacotherapy. " 01/01/2022 - "PubMed, Google Scholar, and PsycInfo were searched with no time restriction using the subject headings binge eating disorder, treatment, review, guidelines, psychotherapy, primary care, and pharmacotherapy. "
3.	Bariatric Surgery 12/01/2008 - "Best short-term results were observed in patients devoid of binge eating disorder with a BMI in the 30.0-40.0 kg/m(2) range; the BIB also helped to prepare superobese patients for bariatric surgery. " 08/01/2022 - "This study assessed the relationships between binge eating disorder (BED) and eating self-efficacy in a sample of patients prior to bariatric surgery. " 01/01/2017 - "Our study aimed to identify differences in binge-eating disorder (BED) prevalence in bariatric surgery candidates with and without OSA. " 09/01/2013 - "The objective of the study was to compare changes in weight, symptoms of depression, and quality of life in extremely obese individuals with binge eating disorder undergoing bariatric surgery or a lifestyle modification intervention. " 03/01/2012 - "Prior studies have reached contradictory conclusions concerning whether binge eating disorder (BED) is associated with greater psychopathology in extremely obese patients who seek bariatric surgery. "
4.	Caloric Restriction 01/01/2002 - "This study examined the factors associated with the diagnostic outcome of obese individuals with and without binge eating disorder (BED) 1 year after completing a very low calorie diet (VLCD) program. " 09/01/2002 - "The female binge eating disorder (BED) patients (n = 20), involved in a residential weight control treatment including low-calorie diet (1200 cal/day) and physical training, were randomly assigned either to the multidimensional VR treatment or to psychonutritional groups based on the cognitive-behavior approach. " 01/01/2002 - "Effect of a very low calorie diet on the diagnostic category of individuals with binge eating disorder." 05/01/1994 - "Binge eating disorder affects outcome of comprehensive very-low-calorie diet treatment." 02/01/2006 - "Cognitive behavioural therapy does not improve outcome in obese women with binge eating disorder receiving a comprehensive very low calorie diet programme."
5.	Secondary Prevention 01/01/2023 - "Our study emphasizes that patients with binge-eating disorder would benefit from being screened for mental health and gastrointestinal comorbidities, and clinicians should consider history of unhealthy weight control behaviors to inform treatment and relapse prevention." 08/01/1998 - "Cognitive-behavioral self-help may be of value both as an initial treatment for binge eating disorder and as a form of secondary prevention." 01/01/2019 - "The efficacy of different forms of self-help interventions for bulimia nervosa, binge eating disorder, and other eating disorders at various stages of the care pathway (from prevention to relapse prevention) is described. "