Binge-Eating Disorder (Binge Eating Disorder)

A disorder associated with three or more of the following: eating until feeling uncomfortably full; eating large amounts of food when not physically hungry; eating much more rapidly than normal; eating alone due to embarrassment; feeling of disgust, DEPRESSION, or guilt after overeating. Criteria includes occurrence on average, at least 2 days a week for 6 months. The binge eating is not associated with the regular use of inappropriate compensatory behavior (i.e. purging, excessive exercise, etc.) and does not co-occur exclusively with BULIMIA NERVOSA or ANOREXIA NERVOSA. (From DSM-IV, 1994)

Also Known As:

Networked: 292 relevant articles (36 outcomes, 95 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Bulimia Nervosa
2.	Bulimia (Binge Eating)
3.	Weight Loss (Weight Reduction)
4.	Anorexia Nervosa
5.	Obesity

Experts

1.	McElroy, Susan L: 27 articles (07/2015 - 03/2002)
2.	Hudson, James I: 18 articles (03/2015 - 11/2002)
3.	Keck, Paul E: 16 articles (07/2015 - 03/2002)
4.	Guerdjikova, Anna I: 14 articles (07/2015 - 02/2005)
5.	Grilo, Carlos M: 13 articles (04/2014 - 02/2005)
6.	Mitchell, James E: 11 articles (07/2015 - 01/2002)
7.	Monteleone, Palmiero: 10 articles (05/2008 - 11/2003)
8.	Maj, Mario: 10 articles (05/2008 - 11/2003)
9.	Masheb, Robin M: 8 articles (04/2014 - 02/2005)
10.	Fassino, Secondo: 7 articles (01/2015 - 07/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Binge-Eating Disorder:

1.	topiramate (Topamax)FDA LinkGeneric 05/01/2000 - "Topiramate may be an effective treatment for binge-eating disorder. " 09/01/2007 - "Double-blind, randomized, placebo-controlled trial of topiramate plus cognitive-behavior therapy in binge-eating disorder." 04/01/2002 - "Topiramate use in obese patients with binge eating disorder: an open study." 05/01/2000 - "Controlled studies of topiramate in binge-eating disorder appear warranted." 01/01/2009 - "Given its potential role in stabilizing mood and reducing impulse control problems and weight, topiramate has been proposed as a treatment for obese patients with binge eating disorder (BED). "
2.	Serotonin (5 Hydroxytryptamine)IBA 07/01/2004 - "While fewer studies have been done in BN or binge eating disorder, there may be disturbances of serotonin metabolism in similar brain regions. " 10/01/2003 - "Obese women with binge-eating disorder (OB-BED) were recently found to have reduced 5-HT transporter binding. " 01/01/1996 - "Recent studies have suggested that antidepressants, particularly serotonin selective reuptake inhibitors, may be effective in the treatment of binge-eating disorder. " 08/01/2010 - "We report the successful treatment of a case of refractory binge eating disorder (BED) with duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, resulting in complete remission of the patient's bingeing behaviours. " 01/01/2005 - "Use of sibutramine, an inhibitor of the reuptake of serotonin and noradrenaline, in the treatment of binge eating disorder: a placebo-controlled study."
3.	sibutramine (Meridia)FDA Link 01/01/2005 - "The findings suggest sibutramine is an effective medication in the treatment of binge-eating disorders and is well tolerated. " 01/01/2008 - "This study is the first large-scale, multisite, placebo-controlled trial to test the efficacy of sibutramine in binge eating disorder. " 01/01/2008 - "Efficacy of sibutramine for the treatment of binge eating disorder: a randomized multicenter placebo-controlled double-blind study." 01/01/2005 - "In this randomized, double-blind, placebo-controlled study, the efficacy, safety, and tolerability of sibutramine were evaluated in the treatment of binge-eating disorder in obese patients. " 11/01/2003 - "A randomized, double-blind, placebo-controlled study of sibutramine in the treatment of binge-eating disorder."
4.	Fluoxetine (Prozac)FDA LinkGeneric 02/01/2005 - "Efficacy of cognitive behavioral therapy and fluoxetine for the treatment of binge eating disorder: a randomized double-blind placebo-controlled comparison." 11/01/2004 - "The diverse effects of fluoxetine on the type of food, and in hungry versus sated rats, suggest alternate brain mechanisms should be concomitantly targeted for improved treatment of binge eating disorders." 07/01/2007 - "This study assessed the long-term effects of group behavioral treatment plus individual cognitive behavioral therapy (CBT) and/or fluoxetine in binge eating disorder (BED) patients. " 11/01/2002 - "The purpose of this study was to assess the efficacy and safety of fluoxetine in the treatment of binge-eating disorder. " 11/01/2002 - "A placebo-controlled, randomized trial of fluoxetine in the treatment of binge-eating disorder."
5.	Norepinephrine (Noradrenaline)FDA LinkGeneric 12/01/2005 - "The objective of this study was to evaluate the effectiveness and safety of reboxetine, a selective noradrenaline reuptake inhibitor, in the treatment of obese patients with binge eating disorder (BED). " 08/01/2010 - "We report the successful treatment of a case of refractory binge eating disorder (BED) with duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, resulting in complete remission of the patient's bingeing behaviours. " 01/01/2005 - "Use of sibutramine, an inhibitor of the reuptake of serotonin and noradrenaline, in the treatment of binge eating disorder: a placebo-controlled study." 01/01/2005 - "Sibutramine, a new serotonin and norepinephrine reuptake inhibitor, has been shown in short- and long-term studies to be effective in promoting and maintaining weight loss in obese patients who have binge-eating disorder. " 03/01/2012 - "Duloxetine, a serotonin norepinephrine reuptake inhibitor (SNRI) indicated for the treatment of depression, is used for off-label purposes such as treatment-resistant obsessive compulsive disorder, bulimia, and binge eating disorder. "
6.	Antidepressive Agents (Antidepressants)IBA 01/01/1996 - "This paper reviews the findings of these studies and offers clinical guidelines for the use of antidepressants in binge-eating disorder." 04/01/2008 - "Antidepressants in short-term treatment of binge eating disorder: systematic review and meta-analysis." 01/01/2015 - "In the pharmacotherapy of binge eating disorder the antidepressants are recommended mainly in the case of unsuccessful psychotherapy, and in treating comorbid depression. " 01/15/2008 - "For the treatment of binge-eating disorder and bulimia nervosa, good evidence supports the use of interpersonal and cognitive behavior therapies, as well as antidepressants. " 01/01/1997 - "For anorexia nervosa (AN), the outcome of pharmacotherapy has been poor, in contrast to bulimia nervosa (BN) and binge eating disorder (BED), where pharmacological treatment, primarily with antidepressants, has proved to be effective, at least in the short run. "
7.	Sertraline (Zoloft)FDA LinkGeneric 04/01/2006 - "Previous studies tested the efficacy of sertraline in Binge Eating Disorder (BED) over a period of 6 weeks. " 06/01/2000 - "The authors' goal was to assess the efficacy of sertraline in the treatment of binge eating disorder. " 06/01/2000 - "In a 6-week trial, sertraline was effective and well tolerated in the treatment of binge eating disorder." 06/01/2000 - "Thirty-four outpatients with DSM-IV binge eating disorder were randomly assigned to receive either sertraline (N=18) or placebo (N=16) in a 6-week, double-blind, flexible-dose (50-200 mg) study. " 06/01/2000 - "Placebo-controlled trial of sertraline in the treatment of binge eating disorder."
8.	Fluvoxamine (Luvox)FDA LinkGeneric 12/01/1998 - "In this placebo-controlled trial, fluvoxamine was found to be effective according to most outcome measures in the acute treatment of binge-eating disorder." 12/30/2006 - "We conclude that fluvoxamine and psychodynamic psychotherapy may be effective in treatment of compulsive buyers in comorbidity with binge eating disorder." 12/01/1998 - "The purpose of this study was to assess the efficacy of fluvoxamine in the treatment of binge-eating disorder. " 04/01/2003 - "A double-blind, placebo-controlled trial of fluvoxamine in binge eating disorder: a high placebo response." 12/01/1998 - "Eighty-five outpatients with a DSM-IV diagnosis of binge-eating disorder were randomly assigned to receive either fluvoxamine (N=42) or placebo (N=43) in a 9-week, parallel-group, double-blind, flexible dose (50-300 mg) study at three centers. "
9.	Anti-Obesity Agents (Antiobesity Drugs)IBA 01/01/2002 - "There are scant data about the efficacy of the novel antiobesity agents for binge-eating disorder. " 01/01/2015 - "The data emerging from this study seem to show that, at least in the short term, some specific medications within the classes of antidepressants, anticonvulsants, and antiobesity agents may prove promising in achieving the main objectives in the treatment of binge eating disorder: reducing the frequency of binge eating, reducing weight, and improving the associated psychopathology. " 08/01/2003 - "For binge eating disorder, studies have examined the efficacy of antidepressants (tricyclic antidepressants, selective serotonin re-uptake inhibitors and serotonin/noradrenaline re-uptake inhibitors), antiobesity agents (sibutramine) and antiepileptics associated with weight loss (topiramate), with some evidence of efficacy for these agents."
10.	Glucose (Dextrose)FDA LinkGeneric 12/01/1995 - "This is the first description of a lack of postprandial elevation in CSF glucose concentration in a patient with a binge eating disorder. " 01/01/2013 - "We report the case of a 61-year-old woman with comorbid binge-eating disorder (BED), BP depression, and treatment-resistant type 2 diabetes mellitus (T2DM), in which LMG showed significant efficacy against BED and BP depression and resulted in a drastic decrease in plasma glucose levels. " 01/01/2014 - "Obese adolescents with subclinical binge eating disorder did not have significantly different levels of appetite signaling proteins or glucose. " 01/01/2014 - "Appetite sensations, appetite signaling proteins, and glucose in obese adolescents with subclinical binge eating disorder." 09/01/2006 - "The use of topiramate (TPM) in the treatment of binge-eating disorder, bulimia nervosa, and antipsychotic-induced weight gain has recently increased, however, the exact molecular basis for its effects on body weight reduction and improved glucose homeostasis, is yet to be elucidated. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 03/01/2014 - "This study evaluated controlled treatment studies of pharmacotherapy for binge eating disorder (BED). " 09/01/2008 - "This study evaluated available controlled treatment studies to determine utility of pharmacotherapy for binge-eating disorder (BED). " 01/01/2015 - "Pharmacotherapy of binge-eating disorder: a review." 03/01/2009 - "This report examined the characteristics of subjects interested in binge eating disorder (BED) pharmacotherapy trails who were ineligible for participation. " 03/01/2009 - "Binge eating disorder pharmacotherapy clinical trails--who is left out?"
2.	Bariatric Surgery 12/01/2008 - "Best short-term results were observed in patients devoid of binge eating disorder with a BMI in the 30.0-40.0 kg/m(2) range; the BIB also helped to prepare superobese patients for bariatric surgery. " 01/01/2016 - "Erratum: Binge eating disorder and the outcome of bariatric surgery at one year: A prospective, observational study." 09/01/2013 - "The objective of the study was to compare changes in weight, symptoms of depression, and quality of life in extremely obese individuals with binge eating disorder undergoing bariatric surgery or a lifestyle modification intervention. " 03/01/2012 - "Prior studies have reached contradictory conclusions concerning whether binge eating disorder (BED) is associated with greater psychopathology in extremely obese patients who seek bariatric surgery. " 06/01/2011 - "Binge eating disorder and the outcome of bariatric surgery at one year: a prospective, observational study."
3.	Caloric Restriction 01/01/2002 - "This study examined the factors associated with the diagnostic outcome of obese individuals with and without binge eating disorder (BED) 1 year after completing a very low calorie diet (VLCD) program. " 02/01/2006 - "Cognitive behavioural therapy does not improve outcome in obese women with binge eating disorder receiving a comprehensive very low calorie diet programme." 09/01/2002 - "The female binge eating disorder (BED) patients (n = 20), involved in a residential weight control treatment including low-calorie diet (1200 cal/day) and physical training, were randomly assigned either to the multidimensional VR treatment or to psychonutritional groups based on the cognitive-behavior approach. " 01/01/2002 - "Effect of a very low calorie diet on the diagnostic category of individuals with binge eating disorder." 03/01/1994 - "Because binge eating in obese individuals has been postulated to be a reaction to dietary restriction, we examined the recorded food intake of 17 obese women with and 16 obese women without binge eating disorder (BED) during 1-week periods before and 3 months after a very low calorie diet program in order to determine the effects of dietary restriction on binge eating frequency and severity. "
4.	Meditation 05/01/1999 - "The efficacy of a 6-week meditation-based group intervention for Binge Eating Disorder (BED) was evaluated in 18 obese women, using standard and eating-specific mindfulness meditation exercises. " 05/01/1999 - "An Exploratory Study of a Meditation-based Intervention for Binge Eating Disorder." 09/01/2012 - "Two mind-body modalities, energy psychology and mindfulness meditation, are reviewed for their potential in treating weight loss, stress, and behavior modification related to binge-eating disorder. "
5.	Combined Modality Therapy 01/01/2013 - "To test the brief and long-term clinical efficacy of an enhanced cognitive-behavioral therapy including a virtual reality protocol aimed at unlocking the negative memory of the body (ECT) in morbidly obese patients with binge eating disorders (BED) compared with standard cognitive behavior therapy (CBT) and an inpatient multimodal treatment (IP) on weight loss, weight loss maintenance, BED remission, and body satisfaction improvement, including psychonutritional groups, a low-calorie diet (1200 kcal/day), and physical training. "