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Mediator Complex

A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.
Also Known As:
Mediator Transcription Complex; Mediator-Like Complex; Mediator-Like Complexes; TR-Associated Protein (TRAP) Complex; TRAP (Thyroid Hormone Associated Protein) Complex; Thyroid Hormone-Associated Protein Complex; Mediator Like Complex; Mediator Like Complexes; Thyroid Hormone Associated Protein Complex
Networked: 200 relevant articles (1 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Vahteristo, Pia: 12 articles (01/2023 - 10/2011)
2. Bützow, Ralf: 9 articles (01/2023 - 11/2013)
3. Syring, Isabella: 8 articles (09/2018 - 09/2015)
4. Mäkinen, Netta: 8 articles (01/2017 - 10/2011)
5. Boyer, Thomas G: 7 articles (01/2022 - 09/2014)
6. Ellinger, Jörg: 7 articles (09/2018 - 09/2015)
7. Müller, Stefan C: 7 articles (09/2018 - 09/2015)
8. Aaltonen, Lauri A: 7 articles (01/2017 - 10/2011)
9. Sjöberg, Jari: 7 articles (01/2017 - 10/2011)
10. Xu, Wei: 6 articles (01/2022 - 01/2015)

Related Diseases

1. Inborn Genetic Diseases (Disease, Hereditary)
2. Neoplasms (Cancer)
3. Leiomyoma (Uterine Fibroids)
4. Carcinogenesis
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. Fumarate Hydratase (Fumarase)
2. Catenins
3. Transforming Growth Factors (Transforming Growth Factor)
4. Collagen Type IV (Type IV Collagen)
5. Vitamin D3 24-Hydroxylase
6. Interferon Regulatory Factors
7. Small Interfering RNA (siRNA)
8. Protein S
9. Vitamin D
10. Interferons

Related Therapies and Procedures

1. Castration
2. Uterine Myomectomy
3. Radiotherapy
4. Drug Therapy (Chemotherapy)