Coordination Complexes

Neutral or negatively charged ligands bonded to metal cations or neutral atoms. The number of ligand atoms to which the metal center is directly bonded is the metal cation's coordination number, and this number is always greater than the regular valence or oxidation number of the metal. A coordination complex can be negative, neutral, or positively charged.

Also Known As:

Networked: 244 relevant articles (6 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shrivastav, Anuraag: 5 articles (09/2006 - 04/2002)
2.	Donnelly, Paul S: 4 articles (10/2014 - 11/2009)
3.	Ott, Ingo: 4 articles (09/2014 - 03/2007)
4.	Dou, Q Ping: 4 articles (01/2014 - 08/2008)
5.	Padhye, Subhash: 4 articles (10/2013 - 07/2003)
6.	Gust, Ronald: 4 articles (04/2013 - 03/2007)
7.	Singh, Nand K: 4 articles (09/2006 - 04/2002)
8.	Demoro, Bruno: 3 articles (11/2014 - 12/2010)
9.	Gambino, Dinorah: 3 articles (11/2014 - 12/2010)
10.	Zec, Manja: 3 articles (01/2014 - 09/2011)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2014 - "Molecular imaging is of key importance in cancer research and various metal complexes containing (44)Sc, (64)Cu, (68)Ga, (86)Y, (89)Zr positron emitters can be very useful in this activity. " 01/01/2015 - "One well-known example of metal-based agents is Schiff based metal complexes, which hold great promise for cancer therapy. " 10/01/2010 - "In this review, we highlight recent developments in the design of coinage metal complexes with anti-tumor activity and discuss the emerging importance of quantitative structure-activity relationship methods in the study of anticancer metal complexes. " 03/22/2007 - "Finally, comparison biodistribution studies between 99mTc and 188Re (39) showed a good correlation between the two metal complexes and demonstrated prolonged tumor retention (> or =24 h)." 01/14/2015 - "Finally, high anti-tumor activity of these three metal complexes has also been identified. "
2.	Neuroblastoma 08/16/2010 - "We measure the cytotoxicity of three metal complexes containing the 2,2'-bypyridine ligand, Cu(bpy)(NCS)(2), 1, [Cu(bpy)(2)(H(2)O)](PF(6))(2), 2, and Zn(bpy)(2)(NCS)(2), 3, toward neuroblastoma cells (SK-N-SH) and ovarian cancer cells (OVCAR-3) using two different cell assays. " 08/01/2011 - "Cholesterol did not appear to influence Aβ and Aβ-metal complexes aggregation, but it was effective in protecting neuroblastoma cells against Aβ complexes' toxicity. " 08/01/2011 - "The physiological concentration of cholesterol in the cerebrospinal fluid (CSF) was used in order to determine the extent in which Aβ and Aβ-metal complexes in vitro aggregation and their toxicity on human neuroblastoma cell cultures is affected. " 01/01/2008 - "We compare the effects of beta-amyloid(1-42) and its various metal complexes (beta-amyloid-Al, beta-amyloid-Zn, beta-amyloid-Cu, beta-amyloid-Fe) in human neuroblastoma cells in terms of cell viability, membrane structure properties, and cell morphology. " 06/01/2011 - "The biological effects of the various Aβ-metal complexes were studied in neuroblastoma cell cultures: Aβ-aluminum turned out to be the only species capable of triggering amyloid precursor and tau181 protein overproduction. "
3.	Chagas Disease (American Trypanosomiasis) 12/01/2010 - "Risedronate metal complexes potentially active against Chagas disease." 10/01/2008 - "In conclusion this preliminary data indicates that metal complexes targeted at parasite cysteine proteases show promise for the treatment of both Chagas' disease and leishmaniasis." 06/07/2012 - "In the search for a pharmacological answer to treat Chagas disease, eight metal complexes with two bioactive bisphosphonates, alendronate (Ale) and pamidronate (Pam), were described. " 10/01/2013 - "In our ongoing search for new metal-based chemotherapeutic agents against leishmaniasis and Chagas disease, six new ruthenium-ketoconazole (KTZ) complexes have been synthesized and characterized, including two octahedral coordination complexes-cis,fac-[Ru(II)Cl2(DMSO)3(KTZ)] (1) and cis-[Ru(II)Cl2(bipy)(DMSO)(KTZ)] (2) (where DMSO is dimethyl sulfoxide and bipy is 2,2'-bipyridine)-and four organometallic compounds-[Ru(II)(η(6)-p-cymene)Cl2(KTZ)] (3), [Ru(II)(η(6)-p-cymene)(en)(KTZ)][BF4]2 (4), [Ru(II)(η(6)-p-cymene)(bipy)(KTZ)][BF4]2 (5), and [Ru(II)(η(6)-p-cymene)(acac)(KTZ)][BF4] (6) (where en is ethylenediamine and acac is acetylacetonate); the crystal structure of 3 is described. "
4.	Leishmaniasis 01/01/2004 - "Metal complexes as chemotherapeutic agents against tropical diseases: malaria, trypanosomiasis, and leishmaniasis." 01/01/2004 - "In this review, advances in the use of metal complexes for the treatment of trypanosomiasis, malaria, and leishmaniasis as important representatives of the general area of tropical diseases is described." 01/01/2004 - "Metal complexes as chemotherapeutic agents against tropical diseases: trypanosomiasis, malaria and leishmaniasis." 10/01/2008 - "In conclusion this preliminary data indicates that metal complexes targeted at parasite cysteine proteases show promise for the treatment of both Chagas' disease and leishmaniasis." 10/01/2013 - "In our ongoing search for new metal-based chemotherapeutic agents against leishmaniasis and Chagas disease, six new ruthenium-ketoconazole (KTZ) complexes have been synthesized and characterized, including two octahedral coordination complexes-cis,fac-[Ru(II)Cl2(DMSO)3(KTZ)] (1) and cis-[Ru(II)Cl2(bipy)(DMSO)(KTZ)] (2) (where DMSO is dimethyl sulfoxide and bipy is 2,2'-bipyridine)-and four organometallic compounds-[Ru(II)(η(6)-p-cymene)Cl2(KTZ)] (3), [Ru(II)(η(6)-p-cymene)(en)(KTZ)][BF4]2 (4), [Ru(II)(η(6)-p-cymene)(bipy)(KTZ)][BF4]2 (5), and [Ru(II)(η(6)-p-cymene)(acac)(KTZ)][BF4] (6) (where en is ethylenediamine and acac is acetylacetonate); the crystal structure of 3 is described. "
5.	Breast Neoplasms (Breast Cancer) 08/14/2014 - "The ligand and its metal complexes were screened for their anticancer studies against human breast cancer cell lines MCF-7 and calculated minimum inhibitory concentration and also for antibacterial activity using Kirby-Bauer single disk susceptibility test. " 04/14/2013 - "Studies of the antiproliferative effects of the [ReOX(L1)] system (X = Cl−, NCS− or CN−) on breast cancer cells show that the lability of a monodentate ligand seems to play a key role in the cytotoxic activity of the metal complexes, while the substitution of this ligand by the chelating ligand Ph2btu− completely terminates the cytotoxicity." 01/01/2012 - "Coinage metal complexes against breast cancer." 05/15/2004 - "We have investigated the antitumor functions and mechanisms of 1,2-naphthoquinone-2-thiosemicarbazone (NQTS) and its metal complexes (Cu(2+), Pd(2+), and Ni(2+)) against MCF-7 human breast cancer cells. " 05/26/2011 - "Selective estrogen receptor modulators, such as 17β-estradiol derivatives bound to metal complexes, have been synthesized as targeted probes for the diagnosis and treatment of breast cancer. "

Related Drugs and Biologics

1.	Platinum
2.	Cisplatin (Platino)
3.	Cysteine Proteases (Cysteine Protease)
4.	Cholesterol
5.	DNA (Deoxyribonucleic Acid)
6.	Ligands
7.	Ions
8.	Ruthenium
9.	Proteins (Proteins, Gene)
10.	Gallium

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Quantum Dots (Quantum Dot)
4.	Radiotherapy
5.	Photochemotherapy (Photodynamic Therapy)