Cyclin D2

A cyclin D subtype which is regulated by GATA4 TRANSCRIPTION FACTOR. Experiments using KNOCKOUT MICE suggest a role for cyclin D2 in granulosa cell proliferation and gonadal development.

Networked: 229 relevant articles (4 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sukumar, Saraswati: 8 articles (05/2011 - 05/2003)
2.	Fackler, Mary Jo: 7 articles (05/2011 - 11/2003)
3.	Schimmer, Aaron D: 5 articles (04/2011 - 12/2007)
4.	Mao, Xinliang: 5 articles (04/2011 - 12/2007)
5.	Argani, Pedram: 5 articles (09/2008 - 12/2003)
6.	Hurren, Rose: 4 articles (04/2011 - 12/2007)
7.	Campo, Elias: 4 articles (11/2009 - 02/2004)
8.	Trudel, Suzanne: 3 articles (04/2011 - 12/2007)
9.	Datti, Alessandro: 3 articles (02/2011 - 12/2007)
10.	Rosenwald, Andreas: 3 articles (11/2009 - 02/2004)

Related Diseases

1.	Neoplasms (Cancer) 10/15/2010 - "Moreover, cyclin D2 dramatically reduced tumor growth and development in Apc(Min/+) mice. " 04/19/2012 - "Molecular studies identified a marked attenuation of the PI3K-AKT-β-catenin signaling pathway that led to decreased protein levels of cyclin D2, thereby decreasing tumor cell proliferation in Thrb(PV/PV)-PTU mice. " 10/01/2003 - "To study the cell cycle-regulatory factors involved in ovarian, testicular, and adrenal tumor development in vivo, we have bred Inhalpha mutant mice to mice with targeted disruptions of the p27 and cyclin D2 genes. " 01/01/2015 - "Cyclin D2 is implicated in tumor suppression. " 05/01/2013 - "Altogether, our results confirm that VPA is an anticancer therapeutic drug for the treatment of tumors with epigenetically repressed cyclin D2 expression."
2.	Breast Neoplasms (Breast Cancer) 01/01/2015 - "In our study, we carried out the MSP assay to evaluation the methylation status at CpG islands in the cyclin D2 promoter in breast cancer cases from the Vietnamese population. " 01/01/2015 - "Our results confirmed the cyclin D2 hypermethylation could be used as the potential biomarker which could be applied in prognosis and early diagnosis of Vietnamese breast cancer patients. " 01/01/2015 - "Loss of expression of cyclin d2 by aberrant DNA methylation: a potential biomarker in vietnamese breast cancer patients." 08/01/2008 - "A long-term follow-up study based on a quantitative evaluation of cyclin D2 and RARbeta2 methylation in cirDNA will provide the data on applicability of these markers for breast tumor predictive diagnostics." 08/01/2008 - "The applicability of cyclin D2 and RARbeta2 methylated markers for the development of a breast tumor screening assay was evaluated. "
3.	Multiple Myeloma 01/01/2012 - "Inhibition of cell cycle progression by dual phosphatidylinositol-3-kinase and mTOR blockade in cyclin D2 positive multiple myeloma bearing IgH translocations." 03/17/2011 - "Dysregulation of cyclin D2 contributes to the pathogenesis of multiple myeloma, and can occur through translocations that activate MAF/MAFB or MMSET/FGFR3. " 12/01/2007 - "The oncogene c-maf is frequently overexpressed in multiple myeloma cell lines and patient samples and contributes to increased cellular proliferation in part by inducing cyclin D2 expression. " 11/01/2007 - "The oncogene c-Maf was recently found to be overexpressed in approximately 50% of multiple myeloma cases, and a role for c-Maf in promoting cyclin D2 expression has been postulated. " 04/01/2011 - "Therefore, we found that amitriptyline inhibited cyclin D2 transactivation and HDAC activity and could be a promising treatment for multiple myeloma."
4.	Anoxia (Hypoxia) 09/01/2006 - "Further, hypoxia-exposed pulp cells showed improvement of cell viability, cell-cycle progression, and expression of cyclin D2 with re-oxygenation. " 01/01/2015 - "Furthermore, the expression of cyclin D2 was significantly decreased due to anoxia, while p27 expression was increased. " 04/15/2013 - "In both fetal hearts and H9c2 cells, hypoxia resulted in a significant decrease in a cell division marker cyclin D2 but an increase in a cell division inhibitor p27. " 09/01/2006 - "These findings indicate that hypoxia-induced cell cycle arrest in pulp cells is reversible, while cyclin D2 may play an essential role in the improvement of cell proliferation with re-oxygenation." 04/15/2013 - "Knockdown of TIMP-3 in H9c2 cells significantly increased cyclin D2 and Ki-67 and partially blocked the hypoxia-induced inhibition of cyclin D2 and Ki-67 in H9c2 cells. "
5.	Prostatic Neoplasms (Prostate Cancer) 05/30/2015 - "SMYD3 contributes to a more aggressive phenotype of prostate cancer and targets Cyclin D2 through H4K20me3." 01/01/2011 - "Our results demonstrated the ability of SFN to epigenetically modulate cyclin D2 expression, and provide novel insights into the mechanisms by which SFN may regulate gene expression as a prostate cancer chemopreventive agent." 01/01/2011 - "Promoter hyper-methylation of cyclin D2, a major regulator of cell cycle, is correlated with prostate cancer progression, and restoration of cyclin D2 expression exerts anti-proliferative effects on LnCap prostate cancer cells. " 09/11/2009 - "Despite well known oncogenic function of G1-S cell-cycle progression, cyclin D2 (CCND2) is often silenced epigenetically in prostate cancers. " 12/01/2003 - "Finally, we identified a few genes such as cyclin D2, p19ink4d, and Fas that are directly regulated by Egr-1 in prostate cancer cells and that control cell cycle and survival."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Amitriptyline (Elavil)
3.	Cyclins
4.	Cyclin E
5.	gamma Catenin (Plakoglobin)
6.	Cyclin A
7.	Cyclin D1
8.	Cyclin D3
9.	Histones (Histone)
10.	Tumor Suppressor Protein p14ARF (p14ARF)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Stem Cell Transplantation
3.	Prostatectomy (Retropubic Prostatectomy)
4.	Drug Therapy (Chemotherapy)