Cyclin D

A cyclin subtype that is specific for CYCLIN-DEPENDENT KINASE 4 and CYCLIN-DEPENDENT KINASE 6. Unlike most cyclins, cyclin D expression is not cyclical, but rather it is expressed in response to proliferative signals. Cyclin D may therefore play a role in cellular responses to mitogenic signals.

Also Known As:

Networked: 379 relevant articles (3 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bergsagel, P Leif: 6 articles (03/2013 - 08/2003)
2.	Kuehl, W Michael: 5 articles (03/2014 - 08/2003)
3.	Sicinski, Piotr: 3 articles (01/2014 - 11/2011)
4.	Wong, Chris K C: 3 articles (07/2013 - 02/2010)
5.	Zhang, Yu: 2 articles (10/2015 - 01/2015)
6.	Liu, Fang: 2 articles (03/2015 - 10/2012)
7.	Zelivianski, Stanislav: 2 articles (10/2014 - 10/2010)
8.	Jeruss, Jacqueline S: 2 articles (10/2014 - 10/2010)
9.	Dowdy, Steven F: 2 articles (01/2014 - 12/2003)
10.	Choi, Yoon J: 2 articles (01/2014 - 11/2011)

Related Diseases

1.	Retinoblastoma (Glioblastoma, Retinal) 01/01/2015 - "Deregulation of CDK4/6, cyclin D/P16 and retinoblastoma (Rb) are known aberrations in certain malignancies. " 02/01/2010 - "Under hypoxic condition, the silencing of STC2 reduced while the overexpression of STC2 increased the levels of phosphorylated retinoblastoma and cyclin D in both SKOV3 and MCF7 cells. " 12/01/1999 - "This indicates that the activities of the retinoblastoma family members, via the cyclin D pathway, are likely to be the major targets for MAD1-mediated inhibition of proliferation in primary mouse fibroblasts." 10/10/1998 - "Previously, we have shown that the retinoblastoma susceptibility gene product (pRb), a key substrate of cyclin D-cdk complex, was maintained in the hypophosphorylated state in the CeReS-18-inhibited cells. " 01/01/2015 - "Further study identified GCIP, a Grap2 and cyclin D interacting protein, as a direct target of miR- 9. In addition, GCIP overexpression activated retinoblastoma 1 (Rb) and suppressed E2F transcriptional target expression in osteosarcoma cells. "
2.	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 02/01/2007 - "The most promising results have been seen in mantle cell lymphoma (MCL), likely because of its dependence on Cyclin D, the translation of which is largely regulated by mTOR activity. " 03/01/2003 - "Immunohistochemistry of a biopsied lymph node revealed that lymphoma cells were positive for cyclin D 1. Mantle cell lymphoma (MCL) was diagnosed at clinical stage IV A. " 08/01/1997 - "BCL-1 (PRAD-1/cyclin D-1) overexpression distinguishes the blastoid variant of mantle cell lymphoma from B-lineage lymphoblastic lymphoma." 03/01/2014 - "Increased mitogenic signaling through activation of the mTOR pathway, coupled with deregulation of the Cyclin D/retinoblastoma (Rb) pathway is a common feature of lymphoid malignancies, including plasmacytoma (PCT), multiple myeloma (MM), Burkitt's lymphoma (BL), and mantle cell lymphoma (MCL). " 06/01/1998 - "In non-Hodgkin lymphomas, cyclin D3 immunolabelling was correlated with proliferative activity and progression; a significant exception was seen in cyclin D1-positive mantle cell lymphomas, which were cyclin D-negative. "
3.	Asthma (Bronchial Asthma) 09/01/2006 - "Cyclin D(1) might be essential in the airway remodeling of asthma through ERK signaling pathway." 09/01/2006 - "To evaluate the expression of cyclin D(1) in asthmatic mouse lungs, and to explore the role of cyclin D(1) in bronchial asthma and airway remodeling. " 06/19/2007 - "There is excessive proliferation of CD(4)(+) T lymphocytes in the patients with clinical asthma remission, which may be related to the abnormal expression of CCRP (cyclin D, cyclin E, and P27(kip1)), PI(3)K, and STAT(6)." 05/01/2012 - "To investigate the effects of H(2) Relaxin (Relaxin) on airway remodeling and the expression of cyclin D(1) in a murine model of chronic asthma. " 05/01/2012 - "Relaxin alleviated airway inflammation, airway smooth muscle thickening and airway remodelling in a murine model of chronic asthma, partially by down-regulating the expression level of cyclin D(1)."
4.	Neoplasms (Cancer) 01/01/2013 - "Mechanistically, rapalogs prevent cap-dependent translation, but studies have shown that cap-independent, internal ribosome entry site (IRES)-mediated translation of genes, such as c-myc and cyclin D, can provide a fail-safe mechanism that regulates tumor survival. " 11/01/2001 - "Aberrant levels of p53, p16, cyclin D or E were comparable to published studies indicating that the clinicopathological distribution of these cases did not favor advanced stage tumors. " 08/07/2015 - "Paired analysis of The Cancer Genome Atlas (TCGA) data for regulators of this RB1 phosphorylation identified loss or truncating mutation of negative regulator CDKN2A (p16) and elevated expression of the CDK4/6 activator CCND1 (cyclin D) as also predicting poor survival. " 07/01/2015 - "The emerging, positive clinical data obtained to date finally validate the two decades-old hypothesis that the cyclin D-CDK4/6 pathway is a rational target for cancer therapy." 07/01/2015 - "Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment."
5.	Carcinoma (Carcinomatosis) 04/20/2001 - "The aims of the present study were to determine the interplay between ER, Ki67 and cyclin D(1)in individual cells within the spectrum of human breast lesions ranging from normal to invasive carcinoma by using dual staining immunofluorescence. " 03/01/2006 - "Tissue sections of breast carcinoma and prostate carcinoma were used as positive controls for cyclin D(1) and D(3) staining, respectively. " 09/01/2003 - "Evidence for at least three alternative mechanisms targeting the p16INK4A/cyclin D/Rb pathway in penile carcinoma, one of which is mediated by high-risk human papillomavirus." 01/01/2001 - "Oncogene and suppressor gene expression (cyclin D, p21WAF1, nm23-H1, Rb1, p16INK4A, and p53) was evaluated in 23 follicular thyroid carcinomas diagnosed in 20 women and 3 men operated or reoperated in Institute of Oncology in Gliwice in years 1992-1999. " 05/15/1992 - "We also detected significant levels of cyclin D transcription in two esophageal carcinoma cell lines, even though they did not express detectable amounts of hst-1 transcription. "

Related Drugs and Biologics

1.	Cyclin E
2.	Retinoblastoma Protein
3.	Cyclin D1
4.	Proteins (Proteins, Gene)
5.	Phosphotransferases (Kinase)
6.	Cyclin A
7.	Cyclins
8.	Cyclin-Dependent Kinase Inhibitor p16
9.	Proliferating Cell Nuclear Antigen (PCNA)
10.	Cell Cycle Proteins

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Chemoprevention
3.	Adjuvant Radiotherapy
4.	Transplantation (Transplant Recipients)
5.	Therapeutics