Type 2 von Willebrand Disease

A subtype of von Willebrand disease that results from qualitative deficiencies of VON WILLEBRAND FACTOR. The subtype is divided into several variants with each variant having a distinctive pattern of PLATELET-interaction.
Also Known As:
von Willebrand Disease, Type 2; Type 2A von Willebrand Disease; Type 2B von Willebrand Disease; Type 2M von Willebrand Disease; Type 2N von Willebrand Disease; Type II von Willebrand Disease; Type IIA von Willebrand Disease; Type IIB von Willebrand Disease; Type IIM von Willebrand Disease; Type IIN von Willebrand Disease; von Willebrand Disease, Type 2A; von Willebrand Disease, Type 2B; von Willebrand Disease, Type 2M; von Willebrand Disease, Type 2N; von Willebrand Disease, Type II; von Willebrand Disease, Type IIA; von Willebrand Disease, Type IIB; von Willebrand Disease, Type IIM; von Willebrand Disease, Type IIN
Networked: 197 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Thrombocytopenia (Thrombopenia)
2. Hemorrhage
3. von Willebrand Diseases (von Willebrand's Disease)
4. Blood Platelet Disorders (Thrombocytopathy)
5. Hemophilia A (Haemophilia)


1. Federici, A B: 9 articles (02/2010 - 01/2000)
2. Meyer, D: 8 articles (04/2007 - 06/2000)
3. Mazurier, Claudine: 7 articles (09/2006 - 06/2002)
4. Fressinaud, E: 6 articles (04/2007 - 06/2001)
5. Mazurier, C: 6 articles (12/2004 - 12/2000)
6. Fressinaud, Edith: 5 articles (12/2013 - 02/2003)
7. Favaloro, Emmanuel J: 5 articles (01/2011 - 08/2007)
8. Michiels, Jan Jacques: 5 articles (06/2010 - 06/2004)
9. Canciani, M T: 5 articles (02/2010 - 12/2000)
10. Mannucci, P M: 5 articles (02/2007 - 01/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Type 2 von Willebrand Disease:
1. von Willebrand FactorIBA
2. Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric
3. Platelet Glycoprotein GPIb-IX Complex (Glycoprotein Ib)IBA
4. AntigensIBA
01/01/2011 - "However, after correction for the VWF antigen levels, by calculation of FVIII binding/VWF antigen ratio, only the patients with known von Willebrand disease type 2N (n = 4) had clearly abnormal results. "
09/01/1996 - "vWF containing the S1613P mutation found in some type 2A von Willebrand disease (vWD) patients was observed to undergo proteolysis in vivo resulting in a reduction of high molecular weight vWF and concomitant appearance of rapidly-migrating satellite species, although the overall clearance rate of vWF antigen was similar to wild type vWF. "
11/01/2009 - "Type 2M von Willebrand disease (VWD) is characterized by a qualitative defect in von Willebrand factor (VWF) and diagnosed by a disproportionate decrease in VWF ristocetin cofactor activity (VWF:RCo) as compared with VWF antigen (VWF:Ag). "
11/01/1980 - "The Factor VIII antigen molecules in the plasma of patients with classical type 1 and variant type 2A von Willebrand disease were compared to the Factor VIII antigen molecules in normal plasma. "
09/01/2007 - "In order to better characterize the genotype-phenotype correlation in type 2M von Willebrand disease (VWD), we sequenced the coding region for the mature subunit of the von Willebrand factor (VWF) gene (exons 18-52, including exon/intron boundaries) in 16 index cases originally submitted to the Canadian Type 1 VWD Study as type 1 VWD, but reclassified as type 2M VWD on the basis of phenotype (excessive mucocutaneous bleeding and von Willebrand factor: antigen (VWF:Ag) and/or von Willebrand factor: ristocetin cofactor (VWF:RCo) between 0.05 and 0.50 IU mL(-1) on at least two occasions and RCo/Ag ratio < 0.6 and no loss of high molecular weight multimers). "
5. Heparin (Liquaemin)FDA LinkGeneric
6. ARC 1779IBA
7. von Willebrand factor drug combination factor VIIIIBA
8. RistocetinIBA
9. Factor VIII (Coagulation Factor VIII)IBA
10. CollagenIBA

Therapies and Procedures

1. Analgesia
2. Esophagectomy
3. Cesarean Section (Caesarean Section)
4. General Anesthesia
5. Intranasal Administration