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Off-Label Use

Subscribe to New Research on Off-Label Use

The practice of prescribing or using a drug outside the scope of the drug's official approved label as designated by a regulatory agency concerning the treatment of a particular disease or condition.

Also Known As:

Off-Label Prescribing; Unlabeled Indication; Indication, Unlabeled; Indications, Unlabeled; Off Label Prescribing; Off Label Use; Off-Label Prescribings; Off-Label Uses; Prescribing, Off-Label; Prescribings, Off-Label; Unlabeled Indications; Use, Off-Label; Uses, Off-Label

Networked: 609 relevant articles (30 outcomes, 81 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 15318
- Drug Therapy: 178671
  - Drug Prescriptions: 375
    - Off-Label Use: 609

Experts

1.	de la Torre, Juan Carlos: 3 articles (07/2015 - 07/2011)
2.	Lapeyre-Mestre, Maryse: 3 articles (05/2015 - 08/2008)
3.	De Sarro, Giovambattista: 3 articles (10/2014 - 11/2010)
4.	Gallelli, Luca: 3 articles (09/2013 - 11/2010)
5.	Alexander, G Caleb: 3 articles (09/2012 - 12/2008)
6.	Curcio, Daniel: 3 articles (02/2011 - 12/2007)
7.	Hsu, Sylvia: 3 articles (07/2010 - 08/2003)
8.	Ranney, Leah M: 3 articles (03/2008 - 03/2008)
9.	Melvin, Cathy L: 3 articles (03/2008 - 03/2008)
10.	Ortiz-Riaño, Emilio: 2 articles (07/2015 - 04/2015)

Related Diseases

1.	Hemorrhage 11/01/2015 - "Off-label use of Hemospray has been shown in several case series to be useful in managing acute bleeding from PHG. " 06/01/2013 - "This case raises the question as to whether earlier off-label use of this agent should be considered when amputation for hemorrhage control is being considered and/or conservation of limited blood assets is needed." 01/01/2013 - "Off-label use in nonhemophilic patients for uncontrolled hemorrhage is increasing although still under investigation. " 09/06/2011 - "A hemorrhage of off-label use." 04/19/2011 - "A hemorrhage of off-label use."
2.	Pain (Aches) 08/01/2014 - "Prostaglandin therapy, as an off label use, leads to a reduction of pain and improvement in mobility." 09/01/2009 - "Publishing studies that involve "off-label" use of drugs: formalizing Regional Anesthesia and Pain Medicine's policy." 02/15/2015 - "A plea for rational mitigation of poor outcomes in the 'off-label use' of medications for the management of pain." 01/01/2014 - "These techniques are not currently approved by the Food and Drug Administration for chronic pain and are, thus, considered off-label use of medical devices for this patient population. " 11/01/2012 - "The wide need for analgesia, anesthesia, and sedation in children and the lack of pediatric labeling leads to widespread off-label use of medications for pain and sedation in children. "
3.	Neoplasms (Cancer) 05/01/2012 - "Off-label use of rhBMP for posterolateral fusion (PLF) was associated with a slightly higher risk of cancer compared with controls in three randomized controlled trials and one poorly conducted retrospective cohort study at various follow-ups. " 05/01/2012 - "Off-label use is particularly widespread in oncology for many reasons, including the wide variety of cancer subtypes, the difficulties involved in performing clinical trials, the rapid diffusion of preliminary results, and delays in the approval of new drugs by regulatory organizations/agencies. " 12/01/2008 - "Ten trials investigating off-label use of ESAs in patients with cancer have reported an increased risk of tumor progression and/or treatment-associated death. " 03/01/2015 - "All other uses were classified as "off- label." Off-label use was further evaluated by whether it conformed to and was supported by National Comprehensive Cancer Network (NCCN) guideline recommendations. " 03/01/2015 - "Prevalence of off-label use of oral oncolytics at a community cancer center."
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 11/01/2008 - "In dermatology, although these agents are licensed only for psoriasis, increasingly off-label use has extended to a number of conditions in which oral mucosal disease is a significant component. " 11/01/2012 - "Off-label use of fumarate therapy for granulomatous and inflammatory skin diseases other than psoriasis vulgaris: a retrospective study." 10/01/2013 - "In dermatology, off-label use is of special importance, for even guideline-endorsed standard therapeutic approaches for common dermatological diseases like atopic eczema, psoriasis, or malignant melanoma are to some extent not licensed for these indications. " 05/01/2014 - "This article will review currently available data and reports on the off-label use of biologics in the treatment of cutaneous diseases other than psoriasis, including inflammatory dermal processes, autoimmune bullous skin diseases, connective-tissue diseases, and hidradenitis suppurativa (HS). " 10/01/2005 - "Other off-label uses of photodynamic therapy have included cutaneous lesions of Bowen's disease, psoriasis, cutaneous T-cell lymphoma and acne. "
5.	Neuralgia (Stump Neuralgia) 02/15/2015 - "Recent advances in our understanding of the mechanisms that underlie the processing of nociceptive stimuli and the perception of pain have led to the increased 'off-label use' of adjuvant medications in an attempt to provide relief for many patients who heretofore have suffered unnecessarily with intractable neuropathic pain. " 09/01/2012 - "The pain reduction is far less than the expectation from patients and physician's under-treatment frequently occur due to the fear of adverse effects or off-label use of these anti-neuropathic pain drugs. " 10/01/2009 - "Despite "off-label" use, ketamine is an important third line option in cases of therapy-resistant neuropathic pain." 04/01/1999 - "Although morphine is the "gold standard," and the only drug approved for intrathecal pain therapy in the United States, off-label use of alternative agents appears promising, particularly in patients with neuropathic pain. " 01/01/2012 - "The objective of this study was to build on previous studies to illustrate implementation of a publication strategy by the drug manufacturer for four off-label uses of gabapentin (Neurontin, Pfizer, Inc.): migraine prophylaxis, treatment of bipolar disorders, neuropathic pain, and nociceptive pain. "

Related Drugs and Biologics

1.	recombinant FVIIa (rFVIIa)
2.	gabapentin (Neurontin)
3.	Factor VIIa (Activated Factor VII)
4.	Ribavirin (Virazole)
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	Vaccines
7.	rituximab (Mabthera)
8.	bevacizumab
9.	pimecrolimus (Elidel)
10.	TNFR-Fc fusion protein (etanercept)

Related Therapies and Procedures

1.	Individualized Medicine
2.	Liver Transplantation
3.	Biological Therapy
4.	Optical Devices
5.	Intensive Care (Surgical Intensive Care)