Grape Seed Extract

07/01/2007 - "Several studies have documented the anticancer and chemopreventive efficacy of grape seed extract (GSE) against various malignancies including prostate cancer (PCA). "
02/20/2004 - "We investigated the in vivo efficacy of grape seed extract (GSE, patented as Traconol) against prostate cancer (PCA) and associated molecular events. "
12/15/2013 - "Assessment of proliferation of prostate cancer PC3 and HBV-replicating HepG2 2.2.15 cells treated with GSEs has shown higher cytotoxicity of red grape seed extract (RW) than white grape seed extract (WW) subjective to dose and period of administration. "
01/01/2011 - "Grape seed extract (GSE) has a known protective effect against prostate cancer. "
12/01/2008 - "To observe the morphological changes of prostate cancer PC-3 cells induced by grape seed extract (GSE). "

05/01/2014 - "Various natural agents, including grape seed extract (GSE), have shown considerable chemopreventive and anti-cancer efficacy against different cancers in pre-clinical studies; however, their specific protein targets are largely unknown and thus, their clinical usefulness is marred by limited scientific evidences about their direct cellular targets. "
09/01/2009 - "This review focuses on recent advancements in cancer chemopreventive and anticancer efficacy of grape seed extract and other grape-based products. "
01/01/2012 - "Grape seed extract has been proven to exert anticancer effects on different tumors. "
09/01/2009 - "Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products."
06/15/2007 - "Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice."

01/01/2010 - "The goal of this study was to investigate effects of grape seed extract on neurons and glia in trigeminal ganglia and trigeminal nucleus caudalis in response to persistent temporomandibular joint inflammation. "
10/01/2014 - "Grape seed extract improves epithelial structure and suppresses inflammation in ileum of IL-10-deficient mice."
05/01/2009 - "Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity."
02/01/2009 - "Grape seed extract (GSE) represents a rich source of proanthocyanidins with the potential to decrease oxidative damage and inflammation within the gastrointestinal tract. "
02/01/2015 - "Proanthocyanidin from grape seed extract inhibits airway inflammation and remodeling in a murine model of chronic asthma."

09/01/2013 - "Improvement in Memory and Brain Long-term Potentiation Deficits Due to Permanent Hypoperfusion/Ischemia by Grape Seed Extract in Rats."
01/01/2008 - "This study was designed to determine the possible protective effect of grape seed extract (GSE), a widely used antioxidant dietary supplement, on hepatic ischemia/reperfusion (I/R) injury. "
09/03/2004 - "In the present study, we investigated the neuroprotective effects of grape seed extract (GSE) in the gerbil hippocampus after 5 min transient forebrain ischemia. "
09/03/2004 - "Neuroprotective effects of grape seed extract on neuronal injury by inhibiting DNA damage in the gerbil hippocampus after transient forebrain ischemia."

07/01/2011 - "Earlier, we found that grape seed extract (GSE) increases Cip/p21 protein level and inhibits growth and induces apoptosis in human colon carcinoma HT29 cells both in vitro and in vivo. "
07/01/2011 - "Grape seed extract upregulates p21 (Cip1) through redox-mediated activation of ERK1/2 and posttranscriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells."
01/01/2008 - "Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells."
05/01/2006 - "Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated-p53 activation."
03/01/2012 - "The 3,3″-di-O-galloyl ester of procyanidin B2 (B2G2) is a component of grape seed extract that inhibits growth of human prostate carcinoma cell lines. "