Nucleoplasmins

A family of histone molecular chaperones that play roles in sperm CHROMATIN decondensation and CHROMATIN ASSEMBLY in fertilized eggs. They were originally discovered in XENOPUS egg extracts as histone-binding factors that mediate nucleosome formation in vitro.

Also Known As:

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Carmona, Margarita: 1 article (12/2015)
2.	Castaño, Ester: 1 article (12/2015)
3.	Delgado-Morales, Raul: 1 article (12/2015)
4.	Ferrer, Isidre: 1 article (12/2015)
5.	Garcia-Esparcia, Paula: 1 article (12/2015)
6.	Gil, Laura: 1 article (12/2015)
7.	Hernández-Ortega, Karina: 1 article (12/2015)
8.	Koneti, Anusha: 1 article (12/2015)
9.	Mukda, Ekchol: 1 article (01/2011)
10.	Pakakasama, Samart: 1 article (01/2011)

Related Diseases

1.	Neoplasms (Cancer) 10/24/2022 - "Nucleoplasmin 2 (NPM2) is a molecular chaperone that binds histones and may play a key role in the development and progression of tumors. " 03/31/2010 - "To exemplify the utility of this amino acid, we caged the nuclear localization sequences (NLSs) of nucleoplasmin and the tumor suppressor p53 in human cells, thus mislocalizing the proteins in the cytosol. "
2.	Carcinogenesis 04/19/2023 - "The nucleoplasmin/nucleophosmin (NPM) family was previously regarded as a critical regulator during disease development, and its mediation in carcinogenesis has achieved intensive attention recently. "
3.	Tetraploidy 10/01/1989 - "Our finding that each probe hybridized to more than one chromosomal locus may reflect the tetraploid nature of the Xenopus laevis genome or results from cross-hybridization to other transcriptionally active members of the NO38/B23-nucleoplasmin or the cytokeratin-lamin gene families. "
4.	Disease Progression 12/01/2015 - "Reduced mRNA expression of nucleolar proteins nucleolin (NCL), nucleophosmin (NPM1), nucleoplasmin 3 (NPM3) and upstream binding transcription factor (UBF), decreased NPM1 but not NPM3 nucleolar protein immunostaining in remaining neurons; diminished 18S rRNA, 28S rRNA; reduced expression of several mRNAs encoding ribosomal protein (RP) subunits; and altered protein levels of initiation factor eIF3 and elongation factor eEF2 of protein synthesis was found in the substantia nigra in PD along with disease progression. "
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2011 - "Mutations in fms-like tyrosine kinase 3 (FLT3) gene including internal tandem duplication (ITD) and point mutation in the tyrosine kinase domain (TKD) as well as in nucleoplasmin (NPM1) gene are associated with pathogenesis of acute myeloblastic leukemia (AML). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Nucleophosmin
3.	fms-Like Tyrosine Kinase 3
4.	Eukaryotic Initiation Factor-3
5.	Lamins
6.	Molecular Chaperones (Chaperone, Molecular)
7.	28S Ribosomal RNA
8.	18S Ribosomal RNA
9.	Messenger RNA (mRNA)
10.	Ribosomal Proteins (Ribosomal Protein)

Related Therapies and Procedures

1.	Lasers (Laser)