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Pagetoid Reticulosis

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A distinct variant of mycosis fungoides characterized by the presence of localized patches or plaques with an intraepidermal proliferation of neoplastic cells.

Also Known As:

Woringer Kolopp Disease; Disease, Ketron-Goodman; Disease, Woringer Kolopp; Disease, Woringer-Kolopp; Ketron Goodman Disease; Kolopp Disease, Woringer; Pagetoid Reticuloses; Reticuloses, Pagetoid; Reticulosis, Pagetoid; Ketron-Goodman Disease; Woringer-Kolopp Disease

Networked: 20 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pagetoid Reticulosis
2.	Mycosis Fungoides
3.	T-Cell Lymphoma (Lymphoma, T Cell)
4.	Primary Cutaneous Anaplastic Large Cell Lymphoma
5.	Lymphomatoid Papulosis

Experts

1.	Jung, S-E: 1 article (06/2015)
2.	Kim, Y C: 1 article (06/2015)
3.	Dirschka, Thomas: 1 article (12/2013)
4.	Bierhoff, Erhard: 1 article (12/2013)
5.	Schmitz, Lutz: 1 article (12/2013)
6.	Camacho, Gloria: 1 article (03/2013)
7.	Castro, Yolanda: 1 article (03/2013)
8.	Requena, Luis: 1 article (03/2013)
9.	Echevarría, Begoña: 1 article (03/2013)
10.	Piris, Miguel Ángel: 1 article (03/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pagetoid Reticulosis:

1.	Monoclonal AntibodiesIBA 01/01/1987 - "Cell populations in pagetoid reticulosis: an immunological study using cell activation associated monoclonal antibodies." 01/01/1984 - "Phenotypic characterization of skin-infiltrating cells in pagetoid reticulosis by monoclonal antibodies." 01/01/1987 - "Using a standard technique involving monoclonal antibodies against T-cell subsets, we have shown that almost all the infiltrating T-cells in the epidermis of a patient with Pagetoid reticulosis (PR), one with epidermotropic mycosis fungoides (EMF) and one with poikiloderma atrophicans vasculare (PAV), were OKT8 positive (presumed cytotoxic/suppressor) T-cells. " 01/01/1984 - "The immunological characterization of the infiltrating cells in a patient with a disseminated form of Pagetoid reticulosis (PR) was carried out-in histological section and cell suspensions--by means of a panel of monoclonal antibodies and classical markers (E-rosette and surface immunoglobulins (SIg]. "
2.	Muramidase (Lysozyme)IBA 01/01/1985 - "Pagetoid reticulosis (Woringer-Kolopp disease): histiocyte marker (lysozyme) study and ultrastructural observations." 01/01/1984 - "Epidermal mononuclear cell infiltrate from three patients with pagetoid reticulosis was examined for the presence of the cytoplasmic markers lysozyme, alpha 1-antitrypsin and alpha 1-antichymotrypsin, using specific antisera and a peroxidase-antiperoxidase technique. "
3.	AntigensIBA 03/01/1989 - "We performed phenotypic studies on two patients with classic localized PaRet (Woringer-Kolopp disease) and one patient with the disseminated type (Ketron-Goodman disease) and compared these with all published reports of cases; both variants show intraepidermal, highly activated, proliferating T cells with variable loss of pan-T-cell antigens, contrasting with nonactivated dermal reactive T cells. " 01/21/1988 - "T-cell antigen deficiencies and clonal rearrangements of T-cell receptor genes in pagetoid reticulosis (Woringer-Kolopp disease)."
4.	gamma-delta T-Cell Antigen Receptors (T-Cell Receptor delta-Chain)IBA 05/01/1991 - "A comparison of our results with those of the literature, which have not included gamma/delta T-cell receptor analysis, suggests that some reported cases of pagetoid reticulosis may have phenotypes similar to our case. " 06/01/1995 - "In this report, we describe the analysis of clonality performed using a PCR-based approach in a group of cutaneous T-cell lymphomas including a case of localised pagetoid reticulosis expressing the gamma delta T-cell receptor. " 06/01/1995 - "PCR detection of clonal tcr gamma-gene rearrangements in a group of cutaneous T-cell lymphomas including a case of localized pagetoid reticulosis expressing the gamma-delta tcr."
5.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/01/1995 - "This was especially evident in cases of Pagetoid reticulosis-like disease in which prominent lymphocyte epidermotropism was not accompanied by keratinocyte ICAM-1 expression. "
6.	CD45 Antigens (CD45 Antigen)IBA 09/01/1991 - "Loss of leucocyte common antigen (CD45) on atypical lymphocytes in the localized but not disseminated type of Pagetoid reticulosis."
7.	SuspensionsIBA 01/01/1984 - "The immunological characterization of the infiltrating cells in a patient with a disseminated form of Pagetoid reticulosis (PR) was carried out-in histological section and cell suspensions--by means of a panel of monoclonal antibodies and classical markers (E-rosette and surface immunoglobulins (SIg]. "
8.	B-Cell Antigen Receptors (B Cell Antigen Receptors)IBA 01/01/1984 - "The immunological characterization of the infiltrating cells in a patient with a disseminated form of Pagetoid reticulosis (PR) was carried out-in histological section and cell suspensions--by means of a panel of monoclonal antibodies and classical markers (E-rosette and surface immunoglobulins (SIg]. "
9.	Peroxidase (Myeloperoxidase)IBA 01/01/1984 - "Epidermal mononuclear cell infiltrate from three patients with pagetoid reticulosis was examined for the presence of the cytoplasmic markers lysozyme, alpha 1-antitrypsin and alpha 1-antichymotrypsin, using specific antisera and a peroxidase-antiperoxidase technique. "
10.	Immune Sera (Antisera)IBA 01/01/1984 - "Epidermal mononuclear cell infiltrate from three patients with pagetoid reticulosis was examined for the presence of the cytoplasmic markers lysozyme, alpha 1-antitrypsin and alpha 1-antichymotrypsin, using specific antisera and a peroxidase-antiperoxidase technique. "

Therapies and Procedures

1.	Aftercare (After-Treatment) 03/01/1995 - "After treatment, the observation of disease-free periods ranging from 18 months to 17 years (mean, 5.9 years) reinforces the view that Woringer-Kolopp disease is a focal pathologic event with a favorable prognosis. "
2.	Photochemotherapy (Photodynamic Therapy) 10/01/2012 - "Pagetoid reticulosis in a prepubescent boy successfully treated with photodynamic therapy." 06/01/2015 - "A case of pagetoid reticulosis treated with fractional laser-assisted photodynamic therapy." 07/01/2005 - "Woringer-Kolopp (localized pagetoid reticulosis) treated with topical photodynamic therapy (PDT)."
3.	Radiotherapy 02/01/2010 - "Pagetoid reticulosis after radiotherapy of primary cutaneous anaplastic large-cell lymphoma."
4.	Lasers (Laser) 06/01/2015 - "A case of pagetoid reticulosis treated with fractional laser-assisted photodynamic therapy."