Mi-2 Nucleosome Remodeling and Deacetylase Complex

A enzyme complex involved in the remodeling of NUCLEOSOMES. The complex is comprised of at least seven subunits and includes both histone deacetylase and ATPase activities.

Also Known As:

Histone Deacetylase Complex MI-2; NuRD Complex; NuRD Histone Deacetylase Complex; Nucleosome Remodeling and Deacetylase Complex; Complex, NuRD; Histone Deacetylase Complex MI 2; Mi 2 Nucleosome Remodeling and Deacetylase Complex; Histone Deacetylase Complex NuRD

Networked: 112 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kumar, Rakesh: 8 articles (12/2014 - 10/2009)
2.	Li, Da-Qiang: 7 articles (12/2014 - 10/2009)
3.	Wade, Paul A: 6 articles (03/2016 - 04/2003)
4.	Shang, Yongfeng: 4 articles (01/2022 - 08/2009)
5.	Mackay, Joel P: 4 articles (01/2020 - 01/2016)
6.	Pakala, Suresh B: 4 articles (01/2012 - 10/2009)
7.	Zhang, Yanping: 3 articles (03/2022 - 10/2009)
8.	Li, Chunxiao: 3 articles (01/2022 - 02/2015)
9.	Li, Tingting: 3 articles (01/2022 - 01/2015)
10.	Liu, Xinhua: 3 articles (01/2022 - 01/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities." 01/01/2020 - "We found that nine subunits, out of 14 subunits of the NuRD complex examined, were significantly overexpressed in HCC, and their expression levels were positively correlated with cancer progression. " 01/01/2020 - "More importantly, the NuRD complex has not yet been investigated as a whole in cancers. " 01/01/2019 - "Our data indicate that the stoichiometry of the NuRD complex is preserved across our three different cancer cell lines. " 02/27/2011 - "Biology of the Mi-2/NuRD Complex in SLAC (Stemness, Longevity/Ageing, and Cancer)."
2.	Neoplasm Metastasis (Metastasis) 05/31/2023 - "The molecular mechanisms by which ZEB1 is regulated by K811 acetylation to promote protein stability, NuRD complex and promoter interactions, and function are relevant to the development of treatment strategies to prevent and treat metastasis in patients with NSCLC." 05/31/2023 - "ZEB1 is Regulated by K811 Acetylation to Promote Stability, NuRD Complex Interactions, EMT, and NSCLC Metastasis." 05/12/2023 - "Implications: The molecular mechanisms by which ZEB1 is regulated by K811 acetylation to promote protein stability, NuRD complex and promoter interactions, and function are relevant to the development of treatment strategies to prevent and treat metastasis in NSCLC patients." 05/12/2023 - "ZEB1 is regulated by K811 acetylation to promote stability, NuRD complex interactions, EMT, and NSCLC metastasis." 01/01/2023 - "ZNF281 drives invasion and metastasis of HCC partially through transcriptional repression of tumor suppressor gene ANXA10 by recruiting NuRD complex."
3.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "Consistently, PELI1 is up-regulated in breast carcinomas, its level is negatively correlated with that of LSD1, and the expression level of the BRD4/LSD1/NuRD complex-restricted genes is strongly correlated with a worse overall survival of breast cancer patients. " 01/01/2022 - "Intriguingly, treatment of breast cancer cells with a small-molecule inhibitor of BRD4, JQ1, results in no immediate activation of the drug-resistant genes, but long-time treatment or destabilization of LSD1 by PELI1 decommissions the BRD4/LSD1/NuRD complex, leading to resistance to JQ1 as well as to a broad spectrum of therapeutic compounds. " 10/15/2017 - "The NuRD complex-mediated p21 suppression facilitates chemoresistance in BRCA-proficient breast cancer." 11/25/2016 - "As a component of NURD histone deacetylase complex, ZIP serves as a tumor suppressor gene in the development of breast tumors. " 03/01/2016 - "To explore the regulatory mechanisms of the NuRD complex, we mapped genome-wide localization of MBD3, a structural component of NuRD, in a human breast cancer cell line (MDA-MB-231) using a modified ChIP-seq protocol. "
4.	Ewing Sarcoma (Sarcoma, Ewing) 07/31/2018 - "Previous studies in Ewing sarcoma (ES) have shown that the Nucleosome Remodeling Deacetylase (NuRD) complex binds directly to EWS-FLI1 oncoprotein and modulates its transcriptional activity. "
5.	Rectal Neoplasms (Rectal Cancer) 08/21/2019 - "In this study, we analyzed the microarray datasets (GSE68204) of rectal cancer from the Gene Expression Omnibus database, and identified CHD4 as one of the most significantly up-regulated genes among all subunits of the nucleosome remodeling and histone deacetylation (NuRD) complex, in non-responders to CCRT, among locally advanced rectal cancer (LARC) patients. "

Related Drugs and Biologics

1.	Nucleosomes (Nucleosome)
2.	Histones (Histone)
3.	Co-Repressor Proteins
4.	Oncogene Proteins (Oncogene Protein)
5.	Globins
6.	EWS-FLI fusion protein
7.	Proteins (Proteins, Gene)
8.	Histone Deacetylases (Histone Deacetylase)
9.	Chromatin
10.	Carrier Proteins (Binding Protein)