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Airway Remodeling

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The structural changes in the number, mass, size and/or composition of the airway tissues.

Also Known As:

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Networked: 1156 relevant articles (37 outcomes, 155 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Asthma (Bronchial Asthma)
2.	Inflammation
3.	Fibrosis (Cirrhosis)
4.	Chronic Obstructive Pulmonary Disease (COPD)
5.	Hyperplasia

Experts

1.	Broide, David H: 26 articles (10/2015 - 02/2004)
2.	Miller, Marina: 21 articles (10/2015 - 02/2004)
3.	Cho, Jae Youn: 21 articles (04/2013 - 02/2004)
4.	Hamid, Qutayba: 18 articles (10/2015 - 06/2003)
5.	Martin, James G: 17 articles (11/2015 - 12/2002)
6.	Meurs, Herman: 17 articles (02/2015 - 10/2004)
7.	Halayko, Andrew J: 16 articles (06/2015 - 01/2006)
8.	Wright, Joanne L: 16 articles (12/2014 - 11/2003)
9.	Churg, Andrew: 15 articles (12/2014 - 11/2003)
10.	Lee, Sook Young: 14 articles (06/2014 - 02/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Airway Remodeling:

1.	Budesonide (Pulmicort)FDA LinkGeneric 03/01/2005 - "Therapeutic administration of Budesonide ameliorates allergen-induced airway remodelling." 10/01/2015 - "[Role of transient receptor potential canonical 1 in airway remodeling and effect of budesonide on its pulmonary expression in asthmatic guinea pigs]." 03/01/2010 - "Budesonide can improve airway remodeling, possibly by decreasing the expression of SDF-1 and CXCR4." 03/01/2005 - "We have used a mouse model of prolonged allergen challenge that exhibits many of the salient features of airway remodelling in order to investigate the anti-remodelling effects of Budesonide. " 10/01/2015 - "Budesonide can partially suppress airway remodeling and inflammation by regulating the expression of TRPC1."
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/01/2015 - "This study was conducted to determine the role of AhR in regulating bronchial epithelial VEGF expression, which might contribute to angiogenesis of airway remodeling. " 11/01/2015 - "Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis and vascular remodeling, important components of airway remodeling. " 02/01/2011 - "We investigated the potential for cysLTs to modulate vascular endothelial growth factor (VEGF) expression, a growth factor involved in the angiogenesis of airway remodelling. " 07/01/2010 - "VEGF (vascular endothelial growth factor) is a potent proangiogenic cytokine, and vascular change is one of the characteristic features of airway remodelling. " 03/01/2009 - "VEGF and its receptors were over-expressed in the sensitized rat model, and involved in angiogenesis and airway remodeling. "
3.	CollagenIBA 01/01/2014 - "Concomitantly, this treatment resulted in an improvement in mucus secretion, a reduction in lung collagen, which are prominent features of airway remodeling. " 03/01/2008 - "In the present study, we established airway remodeling model mice and examined the mechanism of fibrotic change by measuring chemotactic activity of lung fibroblasts and quantifying collagen content in lung tissues. " 02/15/2015 - "Furthermore, NTN(-/-) mice had significantly increased markers of airway remodeling like collagen deposition. " 11/01/2014 - "Moreover, the lung displayed exacerbated airway remodelling, typified by excess peribronchiolar collagen deposition. " 08/01/2013 - "These findings suggest that cooperative interactions between fibrocytes and Th17 cells play an important role via CD40- and IL-17A/F-mediated signaling for collagen and proangiogenic factor production, which may lead to the extracellular matrix deposition and neovascularization seen in airway remodeling. "
4.	tiotropium (Spiriva)FDA Link 05/30/2007 - "Tiotropium bromide may have a beneficial influence on airway remodeling processes in chronic airway diseases through antiproliferative effects on fibroblasts and myofibroblasts." 07/01/2012 - "This study suggests that tiotropium bromide might have an inhibitory effect on airway remodeling in a murine model of chronic asthma. " 07/01/2012 - "Effect of tiotropium bromide on airway remodeling in a chronic asthma model." 08/01/2010 - "The aim of this study was to evaluate whether tiotropium bromide can inhibit allergen-induced acute and chronic airway inflammation, T helper (Th)2 cytokine production, and airway remodelling in a murine model of asthma. " 07/01/2012 - "To investigate the effect of tiotropium bromide on parameters of airway remodeling, including smooth muscle hypertrophy and peribronchial thickening, in a mouse model of chronic asthma. "
5.	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/01/2005 - "To investigate the effect of tyrosine kinase inhibitors (TKIs) on asthmatic rat airway remodeling. " 09/01/2015 - "The nonreceptor tyrosine kinase c-Abl has a role in regulating smooth muscle cell proliferation, which contributes to the development of airway remodeling in chronic asthma. " 01/01/2005 - "[Effect of tyrosine kinase inhibitors on airway remodeling in bronchial asthma]." 05/01/2009 - "To investigate the effects of protein tyrosine kinase on the inflammation and airway remodeling in lung of guinea pigs with bronchial asthma. " 06/01/2015 - "We determined the role of nerve growth factor/tyrosine kinase receptor A signaling in airway remodeling in chronic allergic airway inflammation, and proved that inhibited nerve growth factor (NGF) production ameliorates airway remodeling during chronic allergic airway inflammation. "
6.	CytokinesIBA 05/01/2011 - "This study is first to analyze the inflammatory cytokines, produced by the bronchial epithelium after exposure to areca nut extract (ANE), which contribute to airway remodeling by increasing human bronchial smooth muscle cells (BSMC) migration and proliferation. " 01/01/2013 - "AAD greatly improves the symptoms of allergic airway remodeling probably through inhibition of Th2 cytokines and TGF-β1." 04/01/2012 - "Associated inflammatory changes - cytokines (ELISA), cells in bronchoalevolar lavage and airway remodelling (histology) and β(2) -adrenoceptor density (radioligand binding) - were also measured. " 03/01/2012 - "Non-invasive techniques were developed to reduce invasive methods disadvantages and measure airway remodelling-related markers such as cytokines, inflammatory mediators and others. " 04/01/2011 - "We sought to explore the possibility that migration of ASMCs might contribute to airway remodeling through the action of T(H)17-related cytokines. "
7.	Transforming Growth Factor beta (TGF-beta)IBA 03/01/2008 - "Human studies have demonstrated that anti-IL-5 reduces levels of airway eosinophils expressing TGF-beta, as well as levels of airway remodeling as assessed by bronchial biopsies. " 02/29/2008 - "This study demonstrates a previously unknown modulation of TGF-beta signaling by IL-4, via cav1, suggesting novel therapeutic targets for controlling the effects of TGF-beta and thereby ameliorating pathological airway remodeling." 02/01/2015 - "Transforming growth factor-beta 1 (TGF-β1) is a multifunctional cytokine that plays a pivotal role in airway remodeling observed in the asthmatic airways. " 07/01/2010 - "Upregulation of transforming growth factor-beta (TGF-beta) signaling is interrelated with the development of airway remodeling. " 07/01/2010 - "Effects of Arkadia on airway remodeling through enhancing TGF-beta signaling in allergic rats."
8.	SmokeIBA 12/01/2014 - "To evaluate the role of signal transducer and activator of transcription (STAT)-4 in cigarette smoke-induced small airway remodeling, we used C57BL/6J (wild type [WT]) and STAT4-/- mice exposed to air or cigarette smoke for 6 months and isolated airway and parenchymal fibroblasts. " 01/01/2013 - "The severity of smoke-induced small airway remodeling using various measures was identical in both groups. " 03/01/2011 - "Future research directions in this area include the concentrations of tobacco smoke constituents in the alveolar milieu following SHS exposure, individual susceptibility to SHS, as well as pharmacological treatments for reversing the SHS-induced airway remodelling." 09/01/2007 - "Airway remodeling in the smoke exposed guinea pig model." 04/15/2007 - "Coexposure to environmental tobacco smoke increases levels of allergen-induced airway remodeling in mice."
9.	Adrenal Cortex Hormones (Corticosteroids)IBA 06/01/2000 - "The high efficacy of inhaled corticosteroids has led to their use in milder disease and younger children in the hope that permanent changes in lung function and airway remodelling may be prevented. " 03/01/2015 - "The study suggests that higher dose intranasal corticosteroids might inhibit the airway remodeling of nasal mucosa by reducing MMP-9." 03/01/2007 - "In addition, several recent studies have failed to demonstrate a disease-modifying effect of inhaled corticosteroids, with clinically indicated doses failing to prevent long term deterioration in lung function and potential airway "remodeling". " 09/07/1996 - "Long-term use of inhaled corticosteroids may limit airway remodeling, but there have been few long-term studies to date. " 01/01/2011 - "Mice treated with corticosteroids and subjected to chronic OVA challenge had significantly reduced levels of bFGF, FGF receptor-1, peribronchial TGF-β1+ cells and airway remodeling. "
10.	anti-IgEIBA 09/01/2011 - "Considering the previously demonstrated anti-inflammatory effects of anti-IgE therapy, along with results from a small study showing continued benefit after discontinuation of long-term treatment, a larger study to assess its effect on markers of airway remodeling is underway." 12/01/2015 - "In part, these findings could be attributed to the possible ameliorating effects of anti-IgE treatment on airway remodelling. " 05/01/2010 - "However, the mechanisms underlying the blocking of airway remodeling by anti-IgE antibody remain to be elucidated." 09/01/2011 - "Can anti-IgE therapy prevent airway remodeling in allergic asthma?" 05/01/2010 - "Treatment with anti-IgE antibody inhibited the development of AHR, eosinophilic inflammation, and airway remodeling. "

Therapies and Procedures

1.	Aftercare (After-Treatment) 04/15/2015 - "Airway remodeling was analyzed at baseline and after treatment phase using both fiberoptic bronchoscopy and computed tomography scan. " 10/01/2005 - "Bronchial wall thickening persisted after treatment of acute asthma exacerbation despite improvement in spirometry and decline in FeNO, possibly due to chronic airway remodeling." 04/01/2002 - "A study of the relationships between spirometric indices, airway inflammation, airway remodelling, and bronchial hyperreactivity (BHR) before and after treatment with high dose inhaled fluticasone propionate (FP 750 microg bd) was performed in a group of patients with relatively mild but symptomatic asthma. " 04/01/2008 - "After treatment with budesonide/formoterol for 6 months, the expression of VEGF and VEGFR1 was decreased, with correlatory decreased airway remodelling in patients with asthma. "
2.	Transplants (Transplant) 12/01/1999 - "Variable degrees of airway inflammation are present in stable lung transplant recipients (LTR), and may lead to airway remodeling and chronic graft dysfunction. " 01/01/2013 - "Complement deficiency and complement inhibition lead to markedly improved tissue oxygenation in transplants, diminished airway remodeling, and accelerated vascular repair. "
3.	Therapeutics 09/01/2013 - "Current therapeutics can ameliorate inflammation, but there is no available therapy proven to prevent or reverse airway remodeling, although reversibility of airway remodeling is suggested by studies in animal models of disease. " 03/01/2006 - "This year we present updates on the management and therapeutics of asthma and research on the relationship of airway remodeling to clinically irreversible disease and continue a discussion about the origins of asthma. " 09/15/2004 - "The priority areas identified for research in asthma include: (1) innate immunity, adaptive immunity, and tolerance; (2) mechanisms and consequences of persistent asthma and asthma exacerbations; (3) airway remodeling: clinical consequences and reversibility (clinical relevance and resolution); (4) genetics/gene-environment interactions, pharmacogenetics; (5) intervention/prevention/therapeutics; and (6) vascular basis of asthma." 11/01/2008 - "Therapeutics targeting IL-13 for the treatment of pulmonary inflammation and airway remodeling." 03/01/2006 - "Immunostimulatory sequences of DNA, which are being investigated as novel therapeutics in asthma, inhibit airway remodeling in mice as well as epithelial expression of MMP-9, an enzyme that degrades the extracellular matrix proteins surrounding the airway."
4.	Stents 02/01/2011 - "These preliminary findings showed good safety and biocompatibility of the new PCL stent when used in the airway remodeling. " 02/01/2011 - "Experimental absorbable stent permits airway remodeling." 01/01/2011 - "Thus, with the aid of OCT, we may be able to accurately determine and quantify the extent of airway remodelling in asthma and chronic obstructive pulmonary disease, detect early pre-cancerous lesions in smokers for chemoprevention, study the upper airway anatomy of patients with obstructive sleep apnea in real time while they are asleep and facilitate optimal selection of stents for those with tracheal obstruction. "
5.	Chemoprevention 01/01/2011 - "Thus, with the aid of OCT, we may be able to accurately determine and quantify the extent of airway remodelling in asthma and chronic obstructive pulmonary disease, detect early pre-cancerous lesions in smokers for chemoprevention, study the upper airway anatomy of patients with obstructive sleep apnea in real time while they are asleep and facilitate optimal selection of stents for those with tracheal obstruction. "