Acute Generalized Exanthematous Pustulosis

Rare skin eruption characterized by acute formation of pustules filled with NEUTROPHILS, fever, and peripheral blood LEUKOCYTOSIS. Most cases are associated with the use of antibiotics (e.g., BETA-LACTAMS).

Also Known As:

Acute Localized Exanthematous Pustulosis; Pustulosis, Exanthematous, Acute Generalized; Pustulosis, Exanthematous, Acute Localized; Acute Generalised Exanthematous Pustulosis

Networked: 542 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Stevens-Johnson Syndrome (Lyell's Syndrome)
2.	Psoriasis (Pustulosis Palmaris et Plantaris)
3.	Hypersensitivity (Allergy)
4.	Eosinophilia
5.	Skin Diseases (Skin Disease)

Experts

1.	Yawalkar, Nikhil: 7 articles (07/2020 - 01/2002)
2.	Ben Salem, Chaker: 6 articles (05/2022 - 04/2008)
3.	Chung, Wen-Hung: 6 articles (09/2020 - 09/2010)
4.	Fathallah, Neila: 5 articles (05/2022 - 10/2010)
5.	Pichler, Werner J: 5 articles (12/2005 - 01/2002)
6.	Denguezli, Mohamed: 4 articles (05/2022 - 04/2008)
7.	Slim, Raoudha: 4 articles (08/2018 - 04/2008)
8.	Shear, Neil H: 4 articles (04/2014 - 03/2003)
9.	Britschgi, Markus: 4 articles (12/2005 - 01/2002)
10.	Boussofara, Lobna: 3 articles (05/2022 - 08/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Generalized Exanthematous Pustulosis:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 02/01/2009 - "Potential side effect of high-dose corticosteroid relapse treatment: acute generalized exanthematous pustulosis (AGEP)." 01/01/1996 - "To our knowledge, acute generalized exanthematous pustulosis due to corticosteroid has not been previously reported." 01/01/1995 - "General corticosteroids were ineffective in preventing and in treating acute generalized exanthematous pustulosis." 01/01/2021 - "Most cases of acute generalized exanthematous pustulosis (AGEP) clear quickly with a systemic corticosteroid, but severe or recalcitrant cases may need other systemic therapies. " 09/01/2016 - "In this work, we report the case of a female patient, 70 years old, who developed generalized pustular psoriasis symptoms while reducing the dose of oral corticosteroids, improperly introduced for the treatment of alleged acute generalized exanthematous pustulosis. "
2.	Interleukin-17 (Interleukin 17)IBA 01/01/2019 - "In addition, IL-17E is up-regulated in neutrophil-rich inflammatory skin diseases, such as pyoderma gangrenosum and acute generalized exanthematous pustulosis. " 10/05/2023 - "Rapid Clearance of Corticosteroid-resistant Targetoid Acute Generalized Exanthematous Pustulosis Using IL-17A Inhibitor: A Case Report."
3.	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 01/01/2023 - "Clinical features of acute generalized exanthematous pustulosis caused by hydroxychloroquine in rheumatology patients and exploration of CARD14 gene mutations." 01/01/2022 - "Acute generalized exanthematous pustulosis induced by generic hydroxychloroquine." 12/01/2021 - "Acute generalized exanthematous pustulosis induced by hydroxychloroquine." 06/01/2021 - "Hydroxychloroquine (HCQ)-induced acute generalized exanthematous pustulosis (AGEP) is poorly described in the literature. " 06/01/2021 - "Hydroxychloroquine-induced acute generalized exanthematous pustulosis: a series of seven patients and review of the literature."
4.	Prednisolone (Predate)FDA LinkGeneric 02/01/2021 - "Acute generalised exanthematous pustulosis secondary to prednisolone: an unlikely suspect." 01/18/2021 - "Skin biopsy confirmed a diagnosis of acute generalised exanthematous pustulosis, which resolved with oral prednisolone. " 12/01/2014 - "Acute generalized exanthematous pustulosis induced by oral prednisolone." 02/01/2009 - "In this study, we report on the exceptional case of a young female treated with intravenous high-dose prednisolone for optic neuritis who developed acute generalized exanthematous pustulosis (AGEP). " 07/01/2008 - "Acute generalized exanthematous pustulosis induced by high-dose prednisolone in a young woman with optic neuritis owing to disseminated encephalomyelitis."
5.	Interleukin-8 (Interleukin 8)IBA 01/01/2002 - "However, in acute generalized exanthematous pustulosis (a peculiar form of drug allergy), neutrophils represent the predominant cell type within pustules, probably due to their recruitment by IL-8 secreting drug specific T cells and keratinocytes." 03/01/2010 - "Previous studies have confirmed IL-8 production by T lymphocytes in inflammatory skin diseases with neutrophil-rich infiltrates, such as acute generalized exanthematous pustulosis, Behçet disease, and pustular psoriasis. " 05/01/2013 - "Paediatric acute generalized exanthematous pustulosis induced by paracetamol with high serum levels of interleukin-8 and -22: a case report." 01/01/2002 - "Functional analysis revealed a predominant IL-5 production by drug-specific CD4+ T cells in maculopapular exanthema (MPE) and bullous skin diseases, while patients with acute generalized exanthematous pustulosis have a peculiar T cell subset secreting high amounts of IL-8. " 11/01/2011 - "Sphingomyelinase in Loxosceles venom induces the production of interleukin-8 and granulocyte-macrophage colony-stimulating factor, cytokines involved in the pathogenesis of acute generalized exanthematous pustulosis, providing a mechanism by which Loxosceles reclusa bite may trigger acute generalized exanthematous pustulosis. "
6.	Allopurinol (Remid)FDA LinkGeneric 09/01/2011 - "Allopurinol hypersensitivity syndrome with acute generalized exanthematous pustulosis manifestations." 12/01/2012 - "Allopurinol-induced drug rash with eosinophilia and systemic symptoms mimicking acute generalized exanthematous pustulosis." 01/01/2020 - "We performed a case-control association study by genotyping the HLA-B alleles of 55 patients with AIS [11 toxic epidermal necrolysis (TEN), 21 Steven Johnson syndrome (SJS) 22 drug reaction wit eosinophilia and systemic symptoms (DRESS) and one acute generalized exanthematous pustulosis (AGEP)] and 42 allopurinol-tolerant controls (ATC). "
7.	HLA-B Antigens (HLA-B)IBA 01/01/2022 - "HLA-B*08 also showed a significant correlation with ciprofloxacin-induced acute generalized exanthematous pustulosis (AGEP). " 01/01/2020 - "We performed a case-control association study by genotyping the HLA-B alleles of 55 patients with AIS [11 toxic epidermal necrolysis (TEN), 21 Steven Johnson syndrome (SJS) 22 drug reaction wit eosinophilia and systemic symptoms (DRESS) and one acute generalized exanthematous pustulosis (AGEP)] and 42 allopurinol-tolerant controls (ATC). "
8.	Inosine Monophosphate (IMP)IBA 02/01/2022 - "In this study, we assess the IL-36 staining pattern (IL36-SP) in psoriasis variants and other PDs including lichen simplex chronicus (LSC), prurigo nodularis (PN), lichen planus (LP), tinea, pityriasis rubra pilaris (PRP), mycosis fungoides (MF), pemphigus foliaceus (PF), acute generalized exanthematous pustulosis (AGEP), impetigo (IMP), and syphilis (SY). "
9.	VemurafenibIBA 03/01/2021 - "A systematic search of the following terms: 'vemurafenib', 'cobimetinib', 'dabrafenib', 'trametinib', 'encorafenib', 'binimetinib', 'Acute Generalized Exanthematous Pustulosis', 'Stevens Johnson syndrome', 'Toxic Epidermal Necrolysis', 'Generalized Bullous Fixed Eruption' 'Drug Hypersensitivity Syndrome', and 'DRESS' in simple combination (every drug with each disease) and all in combination, was performed on MEDLINE, EMBASE, Web of Knowledge and The Cochrane Library repositories, with no restriction on language, for original studies. "
10.	binimetinibIBA 03/01/2021 - "A systematic search of the following terms: 'vemurafenib', 'cobimetinib', 'dabrafenib', 'trametinib', 'encorafenib', 'binimetinib', 'Acute Generalized Exanthematous Pustulosis', 'Stevens Johnson syndrome', 'Toxic Epidermal Necrolysis', 'Generalized Bullous Fixed Eruption' 'Drug Hypersensitivity Syndrome', and 'DRESS' in simple combination (every drug with each disease) and all in combination, was performed on MEDLINE, EMBASE, Web of Knowledge and The Cochrane Library repositories, with no restriction on language, for original studies. "

Therapies and Procedures

1.	Therapeutics 01/01/2021 - "Acute localized exanthematous pustulosis: Clinical features, pathophysiology, and therapy." 07/27/2016 - "Acute Generalized Exanthematous Pustulosis: Pathogenesis, Genetic Background, Clinical Variants and Therapy." 01/01/2013 - "Acute generalized exanthematous pustulosis during antituberculosis therapy." 05/01/2019 - "Acute generalized exanthematous pustulosis (AGEP)-like contact dermatitis resulting from topical therapy in a polysensitized patient." 01/01/2022 - "Acute generalized exanthematous pustulosis: a complication of COVID-19 infection or therapy?"
2.	Drug Therapy (Chemotherapy) 11/01/1999 - "Acute generalized exanthematous pustulosis in patients receiving high-dose chemotherapy." 04/01/2022 - "Acute Generalized Exanthematous Pustulosis: A Painful and Pruritic Presentation of Pustulosis Following Pharmacotherapy for Pharyngeal Phlegmon." 01/01/2020 - "Acute Generalized Exanthematous Pustulosis Caused by the Combination of Pembrolizumab Plus Chemotherapy in a Patient With Squamous-Cell Carcinoma."
3.	Aftercare (After-Treatment) 11/21/2020 - "Upon review of the literature there are only a few cases reported of acute generalized exanthematous pustulosis (AGEP) in COVID-19 patients after treatment. " 08/01/2002 - "Diffuse pustular eruption after treatment of dog bite: acute generalized exanthematous pustulosis (AGEP) due to antibiotic therapy."
4.	Stem Cell Transplantation 07/01/2010 - "Acute generalized exanthematous pustulosis in a patient after stem cell transplantation."
5.	Adjuvant Radiotherapy 12/07/2023 - "Acute generalized exanthematous pustulosis induced by exemestane during adjuvant radiotherapy for breast cancer."