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Acute Generalized Exanthematous Pustulosis

Subscribe to New Research on Acute Generalized Exanthematous Pustulosis

A rare skin eruption that is characterized by acute, extensive formation of sterile pustules, fever, and peripheral blood LEUKOCYTOSIS.

Also Known As:

Acute Localized Exanthematous Pustulosis; Pustulosis, Exanthematous, Acute Generalized; Pustulosis, Exanthematous, Acute Localized

Networked: 285 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Skin and Connective Tissue Diseases
- Skin Diseases: 8226
  - Acute Generalized Exanthematous Pustulosis: 285

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris)
2.	Skin Diseases
3.	Optic Neuritis (Retrobulbar Neuritis)
4.	Toxic Epidermal Necrolysis (Lyell's Syndrome)
5.	Hypersensitivity (Allergy)

Experts

1.	Chung, Wen-Hung: 3 articles (05/2014 - 09/2010)
2.	Brenner, Sarah: 3 articles (07/2006 - 09/2003)
3.	Lorette, G: 3 articles (06/2003 - 05/2000)
4.	Pichler, Werner J: 3 articles (08/2002 - 01/2002)
5.	Schwartz, Robert A: 2 articles (11/2015 - 01/2010)
6.	da Cunha Filho, Roberto Rheingantz: 2 articles (06/2015 - 09/2010)
7.	Temiz, Peyker: 2 articles (01/2015 - 01/2008)
8.	Yamamoto, Toshiyuki: 2 articles (01/2015 - 06/2008)
9.	Hung, Shuen-Iu: 2 articles (05/2014 - 09/2010)
10.	Fraga, Garth R: 2 articles (05/2014 - 11/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Generalized Exanthematous Pustulosis:

1.	Interleukin-8 (Interleukin 8)IBA 01/01/2002 - "However, in acute generalized exanthematous pustulosis (a peculiar form of drug allergy), neutrophils represent the predominant cell type within pustules, probably due to their recruitment by IL-8 secreting drug specific T cells and keratinocytes." 03/01/2010 - "Previous studies have confirmed IL-8 production by T lymphocytes in inflammatory skin diseases with neutrophil-rich infiltrates, such as acute generalized exanthematous pustulosis, Behçet disease, and pustular psoriasis. " 05/01/2013 - "Paediatric acute generalized exanthematous pustulosis induced by paracetamol with high serum levels of interleukin-8 and -22: a case report." 01/01/2002 - "Functional analysis revealed a predominant IL-5 production by drug-specific CD4+ T cells in maculopapular exanthema (MPE) and bullous skin diseases, while patients with acute generalized exanthematous pustulosis have a peculiar T cell subset secreting high amounts of IL-8. " 11/01/2011 - "Sphingomyelinase in Loxosceles venom induces the production of interleukin-8 and granulocyte-macrophage colony-stimulating factor, cytokines involved in the pathogenesis of acute generalized exanthematous pustulosis, providing a mechanism by which Loxosceles reclusa bite may trigger acute generalized exanthematous pustulosis. "
2.	Prednisolone (Predate)FDA LinkGeneric 12/01/2014 - "Acute generalized exanthematous pustulosis induced by oral prednisolone." 02/01/2009 - "In this study, we report on the exceptional case of a young female treated with intravenous high-dose prednisolone for optic neuritis who developed acute generalized exanthematous pustulosis (AGEP). " 07/01/2008 - "Acute generalized exanthematous pustulosis induced by high-dose prednisolone in a young woman with optic neuritis owing to disseminated encephalomyelitis." 01/01/2006 - "Oral prednisolone induced acute generalized exanthematous pustulosis due to corticosteroids of group A confirmed by epicutaneous testing and lymphocyte transformation tests."
3.	terbinafine (Lamisil)FDA LinkGeneric 01/01/2015 - "Acute generalized exanthematous pustulosis in a child probably induced by terbinafine." 10/01/2013 - "He was diagnosed with acute generalized exanthematous pustulosis (AGEP) because of terbinafine use in the light of history, clinical and histopathological findings. " 10/01/2013 - "Acute generalized exanthematous pustulosis associated with terbinafine: a case report." 11/01/2012 - "Two cases of acute generalized exanthematous pustulosis related to oral terbinafine and an analysis of the clinical reaction pattern." 01/01/2009 - "Terbinafine-induced acute generalized exanthematous pustulosis (AGEP) responsive to high dose intravenous corticosteroid."
4.	Anti-Bacterial Agents (Antibiotics)IBA 11/01/2015 - "Drug-induced acute generalized exanthematous pustulosis is a rare pustular skin reaction, most commonly triggered by antibiotics. " 11/01/2015 - "Antibiotics are the most common cause of acute generalized exanthematous pustulosis; however, a wide variety of drugs has been associated with this condition. " 12/01/2011 - "Acute generalized exanthematous pustulosis (AGEP), characterized by acute onset of numerous sterile, nonfollicular pinhead sized pustules, is common secondary to drugs, in particular, antibiotics. " 02/22/2010 - "Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous drug reaction often caused by beta-lactam antibiotics. " 09/01/2008 - "Acute generalized exanthematous pustulosis is a severe cutaneous eruption caused most commonly by antibiotics. "
5.	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 11/01/2013 - "Acute generalized exanthematous pustulosis induced by hydroxychloroquine: first case report in Canada and review of the literature." 02/01/2010 - "A case of hydroxychloroquine induced acute generalized exanthematous pustulosis confirmed by accidental oral provocation." 01/20/2010 - "[Acute generalized exanthematous pustulosis included by hydroxychloroquine during lupus]." 05/01/2008 - "Acute generalized exanthematous pustulosis induced by hydroxychloroquine: three cases and a review of the literature." 05/01/2006 - "Acute generalized exanthematous pustulosis induced by hydroxychloroquine."
6.	Acetaminophen (Paracetamol)FDA LinkGeneric 06/01/2015 - "Acute generalized exanthematous pustulosis following paracetamol ingestion in a child." 07/01/2006 - "Findings include a female predominance and the overwhelming prevalence of acetaminophen as the culprit agent, adding two more components to what is known about acute generalized exanthematous pustulosis. " 01/01/2004 - "A case of paracetamol-induced acute generalized exanthematous pustulosis in a pregnant woman localized in the neck region." 09/01/2003 - "A case of acute generalized exanthematous pustulosis (AGEP) provoked by a patch test with acetaminophen is described. " 05/01/1998 - "Acute generalized exanthematous pustulosis associated with paracetamol."
7.	Diltiazem (Cardizem)FDA LinkGeneric 02/01/2011 - "We present the case of a 51-year-old male who experienced an acute generalized exanthematous pustulosis due to diltiazem hydrochloride and we review the relevant literature." 02/01/2011 - "Acute generalized exanthematous pustulosis caused by diltiazem." 01/01/2008 - "[Acute generalized exanthematous pustulosis associated with diltiazem]." 11/01/1997 - "Acute generalized exanthematous pustulosis due to diltiazem: confirmation by patch testing." 07/01/1997 - "Acute generalized exanthematous pustulosis secondary to diltiazem therapy."
8.	MercuryIBA 07/01/2008 - "Mercury-induced acute generalized exanthematous pustulosis misdiagnosed as a drug-related case." 08/01/2002 - "Acute generalized exanthematous pustulosis (AGEP) is an uncommon cutaneous eruption that is most often provoked by drugs, by acute infections with enteroviruses, or by mercury. " 06/01/2001 - "Acute generalized exanthematous pustulosis (AGEP) is an uncommon eruption most often provoked by drugs, by acute infections with enteroviruses, or by mercury. " 01/01/2001 - "She had first typical acute generalized exanthematous pustulosis mimicking mercury rash and then urticarial eruption. " 10/01/2008 - "We report a case of acute generalized exanthematous pustulosis, associated with histologically confirmed acute cytolytic hepatitis without liver failure, after application of a topical home-made ointment containing mercury. "
9.	Contrast MediaIBA 11/01/2014 - "Iodinated contrast media-induced acute generalized exanthematous pustulosis confirmed by delayed skin tests." 12/01/2010 - "Acute generalized exanthematous pustulosis caused by radiocontrast media." 12/01/2009 - "Acute generalized exanthematous pustulosis following administration of iodinated contrast agents is a rare but severe form of such reactions. " 08/01/2006 - "Acute generalized exanthematous pustulosis as a delayed dermatotoxic reaction to IV-administered nonionic contrast media." 06/15/2008 - ": The present review addresses the literature regarding the sensitivity and specificity of the various diagnostic methods for evaluating non-immediate (ie, occurring more than 1 hour after drug administration) hypersensitivity reactions associated with beta-lactams and other antibiotics, anticonvulsants, heparins, iodinated contrast media, etc. Such reactions include several clinical entities, which range from mild reactions, such as maculopapular rash and delayed-appearing urticaria, to severe ones, such as acute generalized exanthematous pustulosis (AGEP), Stevens-Johnson syndrome, and toxic epidermal necrolysis (TEN). "
10.	Clindamycin (Cleocin)FDA LinkGeneric 01/01/2008 - "Acute generalized exanthematous pustulosis due to clindamycin." 08/01/2006 - "Acute generalized exanthematous pustulosis induced by clindamycin." 03/01/2003 - "Clindamycin-associated acute generalized exanthematous pustulosis." 06/01/2000 - "We present the first report of acute generalized exanthematous pustulosis induced by the drug clindamycin." 06/01/2000 - "Clindamycin-induced acute generalized exanthematous pustulosis."

Therapies and Procedures

1.	Stem Cell Transplantation 07/01/2010 - "Acute generalized exanthematous pustulosis in a patient after stem cell transplantation."
2.	Drug Therapy (Chemotherapy) 11/01/1999 - "Acute generalized exanthematous pustulosis in patients receiving high-dose chemotherapy."
3.	Aftercare (After-Treatment) 08/01/2002 - "Diffuse pustular eruption after treatment of dog bite: acute generalized exanthematous pustulosis (AGEP) due to antibiotic therapy."
4.	Oral Administration 11/01/1997 - "We report three cases of acute generalized exanthematous pustulosis (AGEP) following oral administration of nystatin. "