Alien Limb Phenomenon

An apraxia characterized by the affected limb having involuntary, autonomous, and seemingly purposeful behaviors that are perceived as being controlled by an external force. Often the affected limb interferes with the actions of the normal limb. Symptoms develop from lesions in the CORPUS CALLOSUM or medial frontal cortex caused by stroke, infarction, and neurodegenerative diseases (e.g., CREUTZFELDT-JAKOB SYNDROME, corticobasal degeneration).

Also Known As:

Anarchic Hand Syndrome; Alien Hand Phenomenons; Alien Hand Syndromes; Alien Leg Syndromes; Alien Limb Phenomenons; Alien Limb Syndromes; Anarchic Hand Syndromes; Leg Syndrome, Alien; Alien Hand Phenomenon; Alien Hand Syndrome; Alien Leg Syndrome; Alien Limb Syndrome; Phenomenon, Alien Hand; Phenomenon, Alien Limb; Syndrome, Alien Hand; Syndrome, Alien Leg; Syndrome, Alien Limb; Syndrome, Anarchic Hand

Networked: 14 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Parkinsonian Disorders (Parkinsonism)
2.	Ideomotor Apraxia
3.	Corticobasal Degeneration
4.	Dystonic Disorders (Writer's Cramp)
5.	Stroke (Strokes)

Experts

1.	Dong, Ming: 1 article (01/2021)
2.	Gan, Lin: 1 article (01/2021)
3.	Jiang, Wei: 1 article (01/2021)
4.	Qu, Kang: 1 article (01/2021)
5.	Yu, Peng: 1 article (01/2021)
6.	Alvarez, Armando: 1 article (10/2020)
7.	Alvarez, Gemayaret: 1 article (10/2020)
8.	Weaver, Martin: 1 article (10/2020)
9.	Chen, Haibo: 1 article (06/2018)
10.	Ma, Xinxin: 1 article (06/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Alien Limb Phenomenon:

1.	Amantadine (Aman)FDA LinkGeneric 01/01/2015 - "After failure to respond to several medications, alien limb syndrome markedly improved with amantadine. " 01/01/2015 - "To the best of our knowledge, this is the first report of a consistent response of severe, forced dystonic alien limb syndrome to amantadine in a patient with CBS." 01/01/2015 - "Alien Limb Syndrome Responsive to Amantadine in a Patient with Corticobasal Syndrome."
2.	Levodopa (L Dopa)FDA LinkGeneric 05/01/2004 - "Atypical parkinsonism (AP) is a term applied to disorders characterized by parkinsonism that evolves rapidly, with poor or transient response to levodopa, or has other associated features such as early falls and postural instability, early autonomic failure, supranuclear gaze palsy, pyramidal or cerebellar signs, alien hand syndrome or severe ideomotor apraxia. " 12/01/2007 - "We report on five patients with a clinical presentation of corticobasal degeneration (CBD), including gradually progressive, asymmetric, L-DOPA-resistant parkinsonism associated variously with apraxia, focal action myoclonus, focal dystonia, cortical sensory loss and alien limb phenomenon. "
3.	Dopamine Agonists (Dopamine Agonist)IBA 01/01/2017 - "Alien limb syndrome induced by a dopamine agonist in a patient with parkinsonism and agenesis of the corpus callosum."
4.	Clonazepam (Rivotril)FDA LinkGeneric 03/01/2010 - "Clonazepam and botulinum toxin for the treatment of alien limb phenomenon."
5.	Botulinum Toxins (Botulinum Toxin)IBA 03/01/2010 - "Clonazepam and botulinum toxin for the treatment of alien limb phenomenon."
6.	erucylphosphocholineIBA 01/01/2012 - "We suggest that the alien hand phenomenon was a result of thinning of the corpus callosum related to EPC."

Therapies and Procedures

1.	Split-Brain Procedure (Split-Brain) 06/01/2017 - "In addition, the patient demonstrated impaired hemispheric interaction with alien hand syndrome, dyscopia-dysgraphia, complete left ear neglect, and other, more complex, split-brain phenomena. "
2.	Therapeutics 01/01/2009 - "Early recognition of unusual manifestations of stroke, such as an acute alien hand syndrome, can lead to timely diagnosis and therapy."
3.	Exercise Therapy (Therapy, Exercise) 01/01/2021 - "Case Report: Good Prognosis of Mixed Alien Hand Syndrome by Verbal-Cue Rehabilitation Exercise."
4.	Combined Modality Therapy 10/01/2015 - "Alien limb syndrome secondary to multimodal treatment of recurrent oligodendroglioma."
5.	Blood Transfusion (Blood Transfusions) 06/01/2018 - "We presented a 57-year-old patient with alien hand syndrome, autotopagnosia, gait disorders, and left ideomotor apraxia after blood transfusion. "