HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Aspirin-Induced Asthma

Subscribe to New Research on Aspirin-Induced Asthma

Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use.

Also Known As:

Asthma, Aspirin-Induced; Aspirin Induced Asthma Syndrome; Aspirin Induced Asthmas; Aspirin-Induced Asthma Syndromes; Aspirin-Induced Asthmas; Asthma Syndrome, Aspirin-Induced; Asthma Syndromes, Aspirin-Induced; Asthma, Aspirin Induced; Asthma, NSAID induced; Asthmas, Aspirin Induced; Asthmas, Aspirin-Induced; Asthmas, NSAID-induced; Induced Asthma, Aspirin; Induced Asthmas, Aspirin; NSAID-induced Asthma; NSAID-induced Asthmas; Syndrome, Aspirin-Induced Asthma; Syndromes, Aspirin-Induced Asthma; Aspirin Induced Asthma; Aspirin-Induced Asthma Syndrome; Asthma, NSAID-induced

Networked: 200 relevant articles (6 outcomes, 24 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Asthma (Bronchial Asthma)
2.	Hypersensitivity (Allergy)
3.	Nasal Polyps (Nasal Polyp)
4.	Urticaria (Hives)
5.	Bronchial Spasm

Experts

1.	Szczeklik, A: 12 articles (01/2012 - 05/2000)
2.	Sanak, Marek: 7 articles (10/2014 - 05/2003)
3.	Sanak, M: 7 articles (01/2012 - 12/2000)
4.	Szczeklik, Andrzej: 6 articles (10/2014 - 03/2002)
5.	Nizankowska, E: 6 articles (09/2002 - 05/2000)
6.	Mastalerz, L: 5 articles (01/2012 - 12/2000)
7.	Park, Hae-Sim: 4 articles (05/2013 - 03/2005)
8.	Cmiel, A: 4 articles (01/2012 - 05/2000)
9.	Micheletto, C: 4 articles (05/2007 - 03/2004)
10.	Tognella, S: 4 articles (05/2007 - 03/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aspirin-Induced Asthma:

1.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 10/01/2014 - "Numerous open trials have demonstrated the beneficial clinical effects of aspirin desensitization (AD) in patients with aspirin-induced asthma (AIA). " 08/01/2007 - "Of the 46 patients previously hospitalized for aspirin/NSAID-induced asthma attacks, 9 (20%) had a 20% to 29% decrease and 6 (13%) had a 30% or greater decrease in FEV(1) during OAC. " 08/01/2007 - "Of 147 patients who reported seeking acute medical care for their historical aspirin/NSAID-induced asthma attacks, 101 (69%) were treated in an emergency department and released, and 46 (31%) required hospitalization. " 03/01/2005 - "In the patient showing aspirin-induced asthma responses, 31 genes were up-regulated and 6 were down-regulated after aspirin treatment. " 12/01/2004 - "Fourteen patients with aspirin-induced asthma and 20 aspirin-tolerating asthmatics, most of them on chronic inhaled corticotherapy, were studied and compared with 10 healthy subjects. "
2.	LeukotrienesIBA 08/01/2004 - "Aspirin-induced asthma (AIA) is associated with increased production of cysteinyl leukotrienes (CysLT). " 08/01/2003 - "3. This results confirmed the role of cysteinic leukotrienes in pathogenesis of aspirin induced asthma." 09/01/2002 - "Aspirin-induced asthma (AIA) is characterized by overproduction of cysteinyl-leukotrienes. " 02/01/2001 - "At the biochemical level, aspirin-induced asthma is characterized by a chronic overproduction of cysteinyl leukotrienes. " 02/01/1996 - "Bronchial overproduction of leukotrienes and inhibition of prostaglandin synthesis are involved in the pathogenesis of aspirin-induced asthma. "
3.	Dinoprostone (PGE2)FDA Link 02/01/1996 - "These results confirm that PGE2 is highly effective in preventing aspirin-induced asthma and suggest that this effect is mediated by inhibition of sulfidopeptide leukotriene production." 05/01/2003 - "Recent studies have reported that patients with NSAID-induced asthma have a low production of PGE2 in respiratory epithelial cells, bronchial fibroblast and peripheral blood cells. " 01/01/2008 - "This different response might indicate COX-1-dependent prostaglandin E2 control of inflammatory cells in aspirin-induced asthma. " 01/01/2008 - "A special regulatory role for prostaglandin E2 has been postulated in aspirin-induced asthma. " 05/01/2003 - "Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma."
4.	Cromolyn Sodium (Cromoglicic Acid)FDA LinkGeneric 08/01/1993 - "Recently, we have reported that a nebulized solution of sodium cromoglycate (SCG) (Intal), a well known antiallergic agent, has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA). " 04/01/1997 - "The protective activity of nedocromil sodium and of sodium cromoglycate against aspirin-induced asthma has never been investigated in controlled studies. " 02/01/1998 - "We evaluated the effects of pretreatment with cromolyn sodium on bronchoconstriction precipitated by inhalation of sulpyrine in ten adult patients with mild aspirin-induced asthma. " 02/01/1998 - "Cromolyn sodium prevents bronchoconstriction and urinary LTE4 excretion in aspirin-induced asthma." 04/01/1997 - "We conclude that, at the recommended therapeutic doses, sodium cromoglycate and nedocromil sodium are equally effective in attenuating aspirin-induced bronchoconstriction and that it is unlikely that platelet activation participates in the pathogenesis of aspirin-induced asthma."
5.	Leukotriene Antagonists (Leukotriene Receptor Antagonists)IBA 09/01/2001 - "The role of leukotriene antagonists on the conversion from aspirin-induced asthma to Churg-Strauss syndrome has aroused attention and been questioned. " 10/01/1991 - "We conclude that the mechanism of aspirin-induced asthma is at least partially mediated by the leukotrienes in the majority of susceptible patients and that leukotriene antagonists may be useful in the treatment of aspirin-induced asthma." 09/15/2000 - "However, clinical studies of the 2 types of leukotriene modifiers--the leukotriene synthesis inhibitors and the leukotriene receptor antagonists (LTRAs)--have established the critical pathogenic role played by leukotrienes in aspirin-induced asthma (AIA). "
6.	Nedocromil (Alocril)FDA Link 04/01/1997 - "The protective activity of nedocromil sodium and of sodium cromoglycate against aspirin-induced asthma has never been investigated in controlled studies. " 04/01/1997 - "We conclude that, at the recommended therapeutic doses, sodium cromoglycate and nedocromil sodium are equally effective in attenuating aspirin-induced bronchoconstriction and that it is unlikely that platelet activation participates in the pathogenesis of aspirin-induced asthma." 04/01/1997 - "Ten patients with aspirin-induced asthma underwent three bronchial challenges with a single dose of lysine acetylsalicylate (LASA) that caused a decrease in FEV1 of 25% or more in a preliminary dose-response test 30 min after inhalation of 4 mg nedocromil sodium, 10 mg sodium cromoglycate, or placebo. "
7.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 04/01/2003 - "Cyclooxygenase-2 inhibitors in aspirin-induced asthma." 03/01/2002 - "New highly specific COX-2 inhibitors appear to be a safe alternative for patients with aspirin-induced asthma." 02/01/2001 - "New evidence suggests that aspirin sensitivity may be linked to the COX-1 pathway, and COX-2 inhibitors, as a result of their selectivity, may be beneficial in patients with aspirin-induced asthma." 02/01/2002 - "Specially was described the cyclooxygenase theory and genetic risk of aspirin induced asthma as well as tolerability of the new COX-2 inhibitors." 01/01/2000 - "However, the well known contraindications for NSAIDs, such as late pregnancy, aspirin-induced asthma, congestive heart failure and renal dysfunction, will so far apply also to the COX-2 inhibitors. "
8.	Leukotriene E4IBA 06/01/2004 - "(2) To investigate BY concentration in relation to urinary leukotriene E4 (LTE4) concentration in order to evaluate the activation of eosinophils in patients with aspirin-induced asthma (AIA). " 01/01/1992 - "Increased excretion of leukotriene E4 during aspirin-induced asthma." 01/01/1991 - "In addition an increased sensitivity of the airways to LTE4 may contribute to the mechanism of aspirin-induced asthma. " 01/01/2006 - "Aspirin induced asthma (AIA) with nasal polyps has the highest basal LTE4 excretion: a study vs AIA without polyps, mild topic asthma, and normal controls." 08/01/2003 - "2. Excretion of LTE4 in patients with aspirin induced asthma raised after oral aspirin provocation and higher level was detected is til 24 hours after challenge. "
9.	Dipyrone (Metamizole)IBA 03/01/1993 - "These results suggest that 81mKr ventilation image on sulpyrine inhalation challenge test is a useful method for evaluating regional ventilatory distribution, but should be further investigated for application to aspirin-induced asthma." 12/01/1998 - "We assessed the effects of pretreatment with acyclovir on bronchoconstriction precipitated by inhalation of sulpyrine in 16 adult patients with mild or moderate aspirin-induced asthma; those who were in stable clinical condition and were hyperresponsive to the sulpyrine provocation test were allocated to this study. " 02/01/1998 - "We evaluated the effects of pretreatment with cromolyn sodium on bronchoconstriction precipitated by inhalation of sulpyrine in ten adult patients with mild aspirin-induced asthma. " 04/01/1989 - "A sulpyrin inhalation test was given to 13 patients with aspirin-induced asthma (AIA) and 8 patients with non-aspirin-induced asthma (non-AIA) to observe the changes in plasma histamine levels before and after challenges. " 02/01/1998 - "Inhalation of cromolyn sodium protects against sulpyrine-induced bronchoconstriction and prevents urinary leukotriene E4 (u-LTE4) excretion in aspirin-induced asthma. "
10.	cysteinyl-leukotrieneIBA 12/01/2000 - "Aspirin-induced asthma (AIA) is a clinical syndrome related to cysteinyl leukotriene overproduction in airways. " 09/01/2000 - "This is a clinical syndrome, called aspirin-induced asthma (AIA), associated with alterations in arachidonate metabolism and cysteinyl-leukotriene overproduction. " 04/01/2011 - "Altered expressions of the key enzymes in arachidonic acid (AA) metabolism, prostaglandin synthase 1 and 2 and cysteinyl leukotriene C(4) synthase, are of importance in understanding aspirin-induced asthma. " 01/01/2004 - "Major advances in the molecular biology of eicosanoids, exemplified by the cloning of cysteinyl-leukotriene receptors and discovery of a whole family of cyclooxygenase enzymes, offer new insights into mechanisms operating in aspirin-induced asthma. " 10/01/2001 - "The decrease in prostaglandin E(2) (PGE(2)) release due to aspirin (ASA)-induced cyclooxygenase inhibition and the increment in cysteinyl leukotriene (Cys-LT) release secondary to the removal of the inhibitory effect of PGE(2) on Cys-LT release have been suggested in the pathogenesis of aspirin-induced asthma (AIA). "

Therapies and Procedures

1.	Intravenous Injections 10/01/1985 - "We studied the effects of intravenous injection of hydrocortisone, as compared to its solvent, in 31 patients with aspirin-induced asthma. "