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Intervertebral Disc Degeneration

Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.
Also Known As:
Disc Degeneration; Disc Degradation; Disk Degeneration; Disk Degradation; Degeneration, Disc; Degeneration, Disk; Degeneration, Intervertebral Disc; Degeneration, Intervertebral Disk; Degenerative Disc Diseases; Degenerative Intervertebral Disc; Degenerative Intervertebral Disk; Degradation, Disc; Degradation, Disk; Disc Degeneration, Intervertebral; Disc Degenerations; Disc Degradations; Disc Disease, Degenerative; Disc, Degenerative Intervertebral; Disk Degeneration, Intervertebral; Disk Degenerations; Disk Degradations; Disk, Degenerative Intervertebral; Intervertebral Disc Degenerations; Intervertebral Disc, Degenerative; Intervertebral Disk Degenerations; Intervertebral Disk, Degenerative; Degenerative Disc Disease; Degenerative Intervertebral Discs; Degenerative Intervertebral Disks; Intervertebral Disk Degeneration
Networked: 3606 relevant articles (205 outcomes, 632 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Pain (Aches)
2. Low Back Pain (Lumbago)
3. Radiculopathy (Radiculopathy, Cervical)
4. Inflammation (Inflammations)
5. Osteoarthritis

Experts

1. An, Howard S: 38 articles (01/2021 - 06/2002)
2. Yang, Huilin: 36 articles (12/2021 - 05/2007)
3. Yang, Cao: 34 articles (06/2022 - 05/2008)
4. Wang, Kun: 30 articles (06/2022 - 01/2016)
5. Masuda, Koichi: 30 articles (12/2021 - 06/2002)
6. Song, Yu: 29 articles (06/2022 - 01/2016)
7. Liu, Hao: 29 articles (04/2022 - 05/2007)
8. Wu, Xinghuo: 26 articles (06/2022 - 05/2008)
9. Risbud, Makarand V: 26 articles (06/2021 - 11/2005)
10. Zhang, Yukun: 25 articles (06/2022 - 10/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Intervertebral Disc Degeneration:
1. Dichlorodiphenyldichloroethane (DDD)IBA
2. Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
3. HydrogelsIBA
4. Proteins (Proteins, Gene)FDA Link
5. MelatoninIBA
6. Proteoglycans (Proteoglycan)IBA
7. Matrix Metalloproteinases (MMPs)IBA
8. Therapeutic UsesIBA
9. polyetheretherketoneIBA
10. p38 Mitogen-Activated Protein KinasesIBA

Therapies and Procedures

1. Therapeutics
2. Diskectomy (Discectomy)
3. Total Disc Replacement
4. Arthroplasty
5. Transplantation