Halo Nevus

A benign skin lesion characterized by a zone of depigmentation surrounding the nevus.
Also Known As:
Nevus, Halo; Nevi, Halo; Halo Nevi
Networked: 29 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Nevus (Nevi)
2. Melanoma (Melanoma, Malignant)
3. Vitiligo
4. Pigmented Nevus (Melanocytic Nevus)
5. Neoplasms (Cancer)


1. Kutzner, Heinz: 2 articles (05/2015 - 04/2004)
2. García-Arpa, M: 2 articles (01/2012 - 01/2012)
3. Vera-Iglesias, E: 2 articles (01/2012 - 01/2012)
4. Sánchez-Caminero, P: 2 articles (01/2012 - 01/2012)
5. Botella-Estrada, Rafael: 1 article (05/2015)
6. Butterfield, Lisa H: 1 article (11/2013)
7. Naveh, Hadas Prag: 1 article (11/2013)
8. Rao, Uma N M: 1 article (11/2013)
9. Jin, S A: 1 article (01/2012)
10. Shin, M-H: 1 article (01/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Halo Nevus:
1. Peroxidase (Myeloperoxidase)IBA
2. S100 Proteins (S 100 Protein)IBA
3. AntibodiesIBA
4. AntigensIBA
06/01/2004 - "Human leukocyte antigen (HLA) class II associations with two subtypes of vitiligo: vitiligo vulgaris and halo nevi associated with vitiligo were investigated. "
07/01/1985 - "It was found that the vast majority of the nevomelanocytes in halo nevi with a dense inflammatory infiltrate markedly expressed HLA-A,B,C antigens, while expression was not demonstrable in nevocellular nests not adjacent to the mononuclear infiltrate. "
07/01/1985 - "These results demonstrate that the expression of HLA-A,B,C antigens on the nevomelanocytes and the cellular composition of the mononuclear inflammatory infiltrate in halo nevi are very similar to that in malignant melanomas and dysplastic neiv. "
07/01/1976 - "Various facets of cellular immunity were altered, namely: 1) a majority of the patients developed enhanced cutaneous reactions to the microbial skin-test antigens (particularly tuberculin) and tumor cells; 2) nine patients developed the equivalent of delayed hypersensitivity reactions or flares at all previous PPD and BCG inoculation sites following subsequent injection of these agents, which supports the concept of immunologic memory for these target antigens; 3) lesions resembling those of "spontaneous" regressed moles (halo-nevi) were observed at previous vaccine sites in 20 patients and generalized depigmentation occurred in three patients; 4) foreign body giant cells in tumor metastasis remote from BCG-PPD-tumor vaccine sites may indicate a cross-reactivity of microbial and tumor antigens; and 5) intralesional inoculation of the nonspecific agents (BCG, PPD, Varidase, and Mumps) resulted in dense mononuclear cell infiltration and complete regression of most of the injected lesions. "
5. Monoclonal AntibodiesIBA
6. Granzymes (Granzyme)IBA
7. interferon beta 1aFDA Link
8. CXCR3 ReceptorsIBA
9. Transforming Growth Factor beta (TGF-beta)IBA
10. CytokinesIBA

Therapies and Procedures

1. Excimer Lasers
2. Radiotherapy