Invasive Pulmonary Aspergillosis

Lung infections with the invasive forms of ASPERGILLUS, usually after surgery, transplantation, prolonged NEUTROPENIA or treatment with high-doses of CORTICOSTEROIDS. Invasive pulmonary aspergillosis can progress to CHRONIC NECROTIZING PULMONARY ASPERGILLOSIS or hematogenous spread to other organs.

Also Known As:

Networked: 557 relevant articles (63 outcomes, 37 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Aspergillosis
2.	Infection
3.	Neutropenia
4.	Lung Injury
5.	Sporotrichosis

Experts

1.	Walsh, Thomas J: 19 articles (08/2015 - 01/2002)
2.	Petraitiene, Ruta: 13 articles (08/2015 - 01/2002)
3.	Petraitis, Vidmantas: 13 articles (08/2015 - 01/2002)
4.	Wiederhold, Nathan P: 11 articles (08/2013 - 10/2004)
5.	Lewis, Russell E: 10 articles (11/2014 - 10/2002)
6.	Kontoyiannis, Dimitrios P: 10 articles (11/2014 - 10/2002)
7.	Bacher, John: 10 articles (11/2010 - 01/2002)
8.	Hope, William W: 9 articles (05/2015 - 07/2006)
9.	Najvar, Laura K: 9 articles (08/2013 - 04/2006)
10.	Bakker-Woudenberg, Irma A J M: 9 articles (01/2013 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Invasive Pulmonary Aspergillosis:

1.	Amphotericin B (Amphotericin)FDA LinkGeneric 11/01/1996 - "We believe that this positive outcome constitutes a change in the natural history of invasive pulmonary aspergillosis in neutropenic patients as a result of the early initiation of high dose amphotericin B. " 07/01/2005 - "The efficacy of therapeutic aerosolized amphotericin B (AMB) was studied in a steroid-immunosuppressed murine model of invasive pulmonary aspergillosis. " 03/01/1994 - "In order to evaluate the efficacy of aerosol amphotericin B administrations for the prevention of invasive pulmonary aspergillosis, a prospective randomized trial has been initiated." 04/01/2012 - "Prophylactic efficacy of single dose pulmonary administration of amphotericin B inhalation powder in a guinea pig model of invasive pulmonary aspergillosis." 10/01/2005 - "The efficacy of nebulized amphotericin B formulations was evaluated in persistently granulocytopenic rats with invasive pulmonary aspergillosis. "
2.	liposomal amphotericin BFDA Link 12/01/2005 - "Efficacy of high loading doses of liposomal amphotericin B in the treatment of experimental invasive pulmonary aspergillosis." 02/01/1993 - "Liposomal amphotericin B was evaluated for toxicity, pharmacokinetic properties and therapeutic efficacy in invasive pulmonary aspergillosis in Sprague-Dawley rats. " 05/01/2013 - "Efficacy of liposomal amphotericin B for prophylaxis of acute or reactivation models of invasive pulmonary aspergillosis." 05/01/2002 - "In common with a proportion of patients with invasive pulmonary aspergillosis (IPA), the efficacy of AmBisome treatment regimens in our rat model remains suboptimal. " 03/01/1999 - "The in vivo efficacy of NS-718 in a rat model of invasive pulmonary aspergillosis was compared with those of D-AmB and L-AmB. "
3.	Itraconazole (Sporanox)FDA LinkGeneric 04/01/2006 - "Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. " 12/01/2006 - "Efficacy of intravenous itraconazole against invasive pulmonary aspergillosis in neutropenic mice." 04/01/2006 - "In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis." 01/01/2002 - "In vivo, the antifungal efficacy of itraconazole has been demonstrated in several non-immunocompromised and immunocompromised animal models of disseminated and invasive pulmonary aspergillosis. " 01/01/2003 - "The efficacy and safety of 2 weeks of intravenous itraconazole (200 mg twice daily for 2 days, then 200 mg once daily for 12 days) followed by 12 weeks of oral itraconazole capsules 200 mg twice daily were evaluated in a multicentre, open trial in 31 immunocompromised patients with invasive pulmonary aspergillosis (IPA). "
4.	voriconazole (Vfend)FDA LinkGeneric 12/01/2011 - "Considering these facts, the authors report a clinical case of invasive pulmonary aspergillosis which illustrates the improved outcomes associated with the extended-spectrum triazole, voriconazole, used in first-line therapy." 12/01/2008 - "A 74-year-old woman given a diagnosis of chronic necrotizing pulmonary aspergillosis in February, 2007 was treated by intravenous voriconazole (VRCZ) and her conditions improved. " 05/01/2000 - "Efficacy of voriconazole against invasive pulmonary aspergillosis in a guinea-pig model." 06/01/2015 - "The present research aimed to develop and characterize a sustained release dry powder inhalable formulation of voriconazole (VRZ) for invasive pulmonary aspergillosis. " 04/01/2015 - "Autoinduction of voriconazole metabolism in a child with invasive pulmonary aspergillosis."
5.	micafungin (FK463)FDA Link 11/01/2009 - "We treated 26 patients with CPA, 19 with chronic necrotizing pulmonary aspergillosis (CNPA) and 7 with aspergilloma, with micafungin between February 2003 and September 2005. " 08/01/2007 - "Successful treatment of refractory chronic necrotizing pulmonary aspergillosis with micafungin." 06/01/2006 - "[Micafungin therapy for a case of chronic necrotizing pulmonary aspergillosis]." 06/01/2002 - "albicans in tissue, micafungin-treated rabbits with invasive pulmonary aspergillosis had no reduction in the concentration of Aspergillus fumigatus in tissue. " 05/01/2004 - "Successful micafungin (FK463) treatment of invasive pulmonary aspergillosis in a patient with acute lymphoblastic leukemia in a phase II study."
6.	galactomannanIBA 04/01/2000 - "It was concluded that, in this model, quantitative galactomannan detection is superior to PCR in diagnosing and monitoring invasive pulmonary aspergillosis." 04/01/2000 - "Quantitative galactomannan detection is superior to PCR in diagnosing and monitoring invasive pulmonary aspergillosis in an experimental rat model." 07/01/2008 - "Fungal burden and therapeutic efficacy were assessed by survival, quantitative culture (CFU counts), galactomannan enzyme immunoassay (GM-EIA), and quantitative PCR (qPCR) in a new guinea pig model of invasive pulmonary aspergillosis using an aerosol challenge. " 06/01/2014 - "Galactomannan detection in bronchoalveolar lavage (BAL) fluid samples (GM test) is currently considered the gold standard test for diagnosing invasive pulmonary aspergillosis (IPA). " 02/01/2009 - "Therefore, we evaluate the value of serum galactomannan assay in the diagnosis of pediatric invasive pulmonary aspergillosis in this study. "
7.	caspofungin (Cancidas)FDA Link 04/01/2008 - "A high-dose-step-down strategy for caspofungin treatment was evaluated in an experimental model of advanced-stage invasive pulmonary aspergillosis. " 04/01/2008 - "Caspofungin prolongs survival of transiently neutropenic rats with advanced-stage invasive pulmonary aspergillosis." 04/01/2006 - "Caspofungin: antifungal activity in vitro, pharmacokinetics, and effects on fungal load and animal survival in neutropenic rats with invasive pulmonary aspergillosis." 10/15/2004 - "A paucity of data exists regarding the pharmacodynamics of caspofungin (CAS) during invasive pulmonary aspergillosis (IPA). " 10/15/2004 - "Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity."
8.	AntigensIBA 05/01/2012 - "[Serum antigens assay combined with chest CT scan in diagnosis of invasive pulmonary aspergillosis]." 06/01/2007 - "He was found to have chronic necrotizing pulmonary aspergillosis based on a high titer of aspergillus antigen and positive antibody. " 12/01/2005 - "She was diagnosed with chronic necrotizing pulmonary aspergillosis, based on isolation for Aspergillus sp. in sputum culture and a positive reaction for Aspergillus antigen in bronchial lavage and Aspergillus antibody in serum. " 04/01/1994 - "Invasive pulmonary aspergillosis diagnosed by antigen detection in urine." 11/17/1990 - "The presence of antigen correctly predicted development of invasive pulmonary aspergillosis (IPA) in 16 patients. "
9.	EchinocandinsIBA 05/01/2008 - "However, paradoxical attenuation of antifungal activity with increasing doses has been reported for some echinocandins in experimental models of invasive pulmonary aspergillosis (IPA). " 08/01/2010 - "Invasive pulmonary aspergillosis is a life-threatening infection in lung transplant recipients; however, no studies of the pharmacokinetics and pharmacodynamics (PKPD) of echinocandins in transplanted lungs have been reported. " 08/01/2009 - "Antifungal monotherapy with polyenes, azoles or echinocandins is not always effective for invasive pulmonary aspergillosis (IPA). " 01/01/2006 - "Micafungin, a new class of the antifungal agent "echinocandin" released in 2002, and voriconazole, a new triazole antifungal agent released in 2005 in Japan have in vitro activities against Aspergillus spp. Results of large-scale clinical trials in Europe and the United States showed voriconazole to have superior efficacy against invasive pulmonary aspergillosis in comparison with conventional amphotericin B, and caspofungin, a member of the echinocandins, was effective as an empirical antifungal therapy in patients with persistent fever and neutropenia. "
10.	posaconazoleFDA Link 10/01/2014 - "Efficacy of PTX3 and posaconazole combination in a rat model of invasive pulmonary aspergillosis." 03/01/2015 - "Posaconazole prophylaxis in experimental azole-resistant invasive pulmonary aspergillosis." 10/01/2014 - "Posaconazole is currently used for the prophylaxis of invasive pulmonary aspergillosis (IPA). " 05/01/2014 - "We evaluated posaconazole exposure in pulmonary epithelial lining fluid (ELF) in a murine model of invasive pulmonary aspergillosis. " 01/01/2013 - "Posaconazole pharmacodynamic target determination against wild-type and Cyp51 mutant isolates of Aspergillus fumigatus in an in vivo model of invasive pulmonary aspergillosis."

Therapies and Procedures

1.	Transplants (Transplant) 01/01/2005 - "We present 3 patients, 2 with recent heart transplants, complicated with invasive pulmonary aspergillosis (IPA), treated successfully with surgical resection. " 09/01/2008 - "To study the value of Aspergillus real-time PCR as a tool for diagnosing invasive pulmonary aspergillosis(IPA) from serum samples in organ transplant recipients. " 06/01/2015 - "Invasive pulmonary aspergillosis due to Aspergillus lentulus: Successful treatment of a liver transplant patient." 04/01/2015 - "Between 2007 and 2013, there were 82 patients who underwent heart transplant at our institution, including 6 patients who were diagnosed with invasive pulmonary aspergillosis. " 10/27/2014 - "Bronchoalveolar lavage lateral-flow device test for invasive pulmonary aspergillosis in solid organ transplant patients: a semiprospective multicenter study."
2.	Liver Transplantation 07/01/2011 - "Invasive pulmonary aspergillosis after living donor liver transplantation should be eradicated or not? " 08/01/2012 - "The purpose of this study was to evaluate the radiological and clinical findings of invasive pulmonary aspergillosis (IPA) after liver transplantation. " 08/01/2012 - "Radiological and clinical findings of 25 patients with invasive pulmonary aspergillosis: retrospective analysis of 2150 liver transplantation cases." 02/01/2008 - "Invasive pulmonary aspergillosis is a rare, but severe and potentially fatal, complication after liver transplantation. " 02/01/2008 - "Invasive pulmonary aspergillosis after liver transplantation: rapid and complete response to combined and sequential antifungal therapy."
3.	Drug Therapy (Chemotherapy) 05/01/2012 - "Complete remission could not be achieved even after several induction chemotherapy regimens, and the patient suffered from invasive pulmonary aspergillosis. " 01/01/2013 - "When clinical trials are designed and implemented to test effective drug therapies in patients with chronic necrotizing pulmonary aspergillosis, the trial patients should be stratified according to these prognostic factors prior to randomization." 02/01/2007 - "This model provides a strategy by which relationships among pathogenesis, immunological effectors, and antifungal drug therapy for invasive pulmonary aspergillosis may be further understood." 04/01/2003 - "The patient died of invasive pulmonary aspergillosis after chemotherapy." 01/01/2002 - "Invasive pulmonary aspergillosis must be considered also in patients with mild immunosuppression and pulmonary infiltrates which do not respond to conventional treatment with antibiotic chemotherapy. "
4.	Stem Cell Transplantation 09/01/2004 - "Successful autologous stem cell transplantation in Ph-positive ALL patient with refractory invasive pulmonary aspergillosis." 01/01/1997 - "Invasive pulmonary aspergillosis complicated by subclavian artery occlusion following allogeneic stem cell transplantation." 01/01/1997 - "We describe an unusual case of invasive pulmonary aspergillosis (IPA) complicated by subclavian artery occlusion in a 32-year-old man with severe aplastic anemia, who underwent allogeneic stem cell transplantation. " 01/01/2007 - "A 35-year-old man developed invasive pulmonary aspergillosis (IPA) with severe neutropenia after umbilical cord stem cell transplantation for chronic myelogenous leukemia. " 10/01/2014 - "Invasive pulmonary aspergillosis (IPA) is a common infection in immunocompromised patients with hematological malignancies or allogenic stem cell transplantation, and is less frequent in the context of chronic obstructive pulmonary disease (COPD). "
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 05/01/2002 - "The efficacy of KT MAbs against Aspergillus fumigatus was investigated in a mouse model of T-cell-depleted allogeneic bone marrow transplantation (BMT) with invasive pulmonary aspergillosis. " 01/01/2009 - "Invasive pulmonary aspergillosis 10 years post bone marrow transplantation: a case report." 04/01/2007 - "A boy, with the same diagnosis, underwent bone marrow transplantation from related donor but died from invasive pulmonary aspergillosis. " 06/15/2005 - "Because of the high risk of leukaemia-relapse bone marrow transplantation (BMT) from a matched unrelated donor was carried out despite invasive pulmonary aspergillosis (IPA). " 01/01/2002 - "To describe the clinical features and diagnostic aspects of invasive pulmonary aspergillosis (IPA) following bone marrow transplantation (BMT). "